Zobrazeno 1 - 10
of 498
pro vyhledávání: '"metabolic switch"'
Publikováno v:
Frontiers in Zoology, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background Anuran metamorphosis, which is driven by thyroid hormone (TH)-mediated processes, orchestrates intricate morphological and functional transformations for the transition from aquatic tadpoles to terrestrial life, providing a valuab
Externí odkaz:
https://doaj.org/article/b6e228db3fcb41638bc8e384afe0acaa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/de30ebc63e3f42f390a916fe77ad4a3c
Autor:
Layla Simón, Keila Torres, Pamela Contreras, Natalia Díaz-Valdivia, Lisette Leyton, Andrew F.G. Quest
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116841- (2024)
Metastasis is the leading cause of cancer-related deaths, making the development of novel, more effective therapies imperative to alleviate patient suffering. Metabolic switching is a hallmark of cancer cells that facilitates metastasis. Cancer cells
Externí odkaz:
https://doaj.org/article/58724a8948a146f0ac77ea9e8bef9b87
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-9 (2024)
Abstract Background Intermittent fasting (IF) is a commonly used dietary practice that alternates between periods of unrestricted dietary consumption and abstinence from caloric intake. IF reduces caloric intake along with metabolic switch from utili
Externí odkaz:
https://doaj.org/article/431322567c6f4d1293f1cee2049888b4
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-4 (2024)
Abstract An intrinsic link between metabolism and function in immune cells, and in particular macrophages, has been well established recently. However, the molecular mechanisms controlling the metabolic switch in these sentinel cells for their integr
Externí odkaz:
https://doaj.org/article/135b64d8260b4ddbbfa0a93087fe0587
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101035- (2024)
The adenosine monophosphate (AMP)-activated protein kinase (AMPK) sits at a central node in the regulation of energy metabolism and tumor progression. AMPK is best known to sense high cellular ADP or AMP levels, which indicate the depletion of energy
Externí odkaz:
https://doaj.org/article/fdae30568fba45adbe8ce480a0faeb65
Autor:
Arturo Valle-Mendiola, Leticia Rocha-Zavaleta, Vilma Maldonado-Lagunas, Diego Morelos-Laguna, Adriana Gutiérrez-Hoya, Benny Weiss-Steider, Isabel Soto-Cruz
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6835 (2024)
The tumor cells reprogram their metabolism to cover their high bioenergetic demands for maintaining uncontrolled growth. This response can be mediated by cytokines such as IL-2, which binds to its receptor and activates the JAK/STAT pathway. Some rep
Externí odkaz:
https://doaj.org/article/aa415e5c733f49f59a692664629dde1c
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4710 (2024)
Sepsis-induced cardiomyopathy (SICM) is one of the leading indicators for poor prognosis associated with sepsis. Despite its reversibility, prognosis varies widely among patients. Mitochondria play a key role in cellular energy production by generati
Externí odkaz:
https://doaj.org/article/720909b3e27844319cbb60eb00c00a96
Autor:
Jingran Zhang, Guang Shi, Junjie Pang, Xing Zhu, Qingcai Feng, Jie Na, Wenbin Ma, Dan Liu, Zhou Songyang
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Post-translational modifications of proteins are crucial to the regulation of their activity and function. As a newly discovered acylation modification, crotonylation of non-histone proteins remains largely unexplored, particularl
Externí odkaz:
https://doaj.org/article/7f1877e24d6e4af0a62c4f3013bf5989
HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver
Autor:
Jonathan R. Deans, Poonamjot Deol, Nina Titova, Sarah H. Radi, Linh M. Vuong, Jane R. Evans, Songqin Pan, Johannes Fahrmann, Jun Yang, Bruce D. Hammock, Oliver Fiehn, Baharan Fekry, Kristin Eckel-Mahan, Frances M. Sladek
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of different isoforms. P1-HNF4α is the major isoform in the adult liver while P2-HNF4α is
Externí odkaz:
https://doaj.org/article/e1a980aa2c3548fca155dbc6f3c46efe