Zobrazeno 1 - 10
of 2 937
pro vyhledávání: '"metabolic stress"'
Publikováno v:
Microbial Cell, Vol 11, Pp 339-352 (2024)
Defining the physiological role of a gene product relies on interpreting phenotypes caused by the lack, or alteration, of the respective gene product. Mutations in critical genes often lead to easily recognized phenotypes that can include changes in
Externí odkaz:
https://doaj.org/article/fc39ba40cef346aa9fc66aa2bef13cf8
Autor:
Robert Bielitzki, Martin Behrens, Tom Behrendt, Alexander Franz, Christoph Centner, Luke Hughes, Stephen D. Patterson, Johnny Owens, Michael Behringer, Lutz Schega
Publikováno v:
Sports Medicine - Open, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Physical exercise induces acute psychophysiological responses leading to chronic adaptations when the exercise stimulus is applied repeatedly, at sufficient time periods, and with appropriate magnitude. To maximize long-term training adaptat
Externí odkaz:
https://doaj.org/article/5db30f1afe5c4b1493e642a2626e7492
Autor:
Julia Jolibois, Alison Domingues, Divina El Hamaoui, Raphaël Awaida, Mathilde Berger-de-Gaillardo, Daniel Guérin, David M Smadja, Perrine Marquet-DeRougé, Isabelle Margaill, Elisa Rossi, Valérie Nivet-Antoine
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background This study explores the potential role of Thioredoxin-interacting protein (TXNIP) silencing in endothelial colony-forming cells (ECFCs) within the scope of age-related comorbidities and impaired vascular repair. We aim to elucidat
Externí odkaz:
https://doaj.org/article/23f9a1a27f634f52abc59e9518de0b30
Autor:
Andriani Angelopoulou, Giorgos Theocharous, Dimitrios Valakos, Aikaterini Polyzou, Sophia Magkouta, Vassilios Myrianthopoulos, Sophia Havaki, Marco Fiorillo, Ioanna Tremi, Konstantinos Vachlas, Theodoros Nisotakis, Dimitris-Foivos Thanos, Anastasia Pantazaki, Dimitris Kletsas, Jiri Bartek, Russell Petty, Dimitris Thanos, Rory J McCrimmon, Angelos Papaspyropoulos, Vassilis G Gorgoulis
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Non-small cell lung cancer (NSCLC) constitutes one of the deadliest and most common malignancies. The LKB1/STK11 tumour suppressor is mutated in ∼ 30% of NSCLCs, typically lung adenocarcinomas (LUAD). We implemented zebrafish and human lun
Externí odkaz:
https://doaj.org/article/e39879f4050a4ba8adc5bd15a456cebe
Autor:
Mathias Redsted, Magnus Grønhøj, Louise Dalsgaard Brøchner, Janne Fassov, Mads Vandsted Svart, Jens Rikardt Andersen, Christian Lodberg Hvas
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Background and aimsAcute severe ulcerative colitis (ASUC) is characterized by systemic inflammation, which may initiate an acute-phase response leading to hypercatabolism. Patients with ASUC are usually treated with high-dose steroids that may furthe
Externí odkaz:
https://doaj.org/article/2c13129a4e5342a19d7789459343e56c
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-23 (2024)
Abstract Background Macrophage activation may play a crucial role in the increased susceptibility of obese individuals to acute lung injury (ALI). Dysregulation of miRNA, which is involved in various inflammatory diseases, is often observed in obesit
Externí odkaz:
https://doaj.org/article/fa2773caf3cd4ecb9ad7a72a465ed09d
Autor:
Mark A. Magnuson, Anna B. Osipovich
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intr
Externí odkaz:
https://doaj.org/article/4e7ff2126f354766aee0e9a2e539acda
Autor:
Tamires dos Santos Vieira, Flávia Vitorino Freitas, Luiz Cláudio Barreto Silva Neto, Aline Ribeiro Borçoi, Suzanny Oliveira Mendes, Amanda Sgrancio Olinda, Ivana Alece Arantes Moreno, Bárbara Risse Quaioto, Marcele Lorentz Mattos de Souza, Wagner Miranda Barbosa, Juliana Krüger Arpini, Bruna Pereira Sorroche, Julia de Assis Pinheiro, Anderson Barros Archanjo, Joaquim Gasparini dos Santos, Lidia Maria Rebolho Batista Arantes, Daniela Rodrigues de Oliveira, Adriana Madeira Alvares da Silva
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
BackgroundDietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms.ObjectiveOur study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of
Externí odkaz:
https://doaj.org/article/662eaf405ade45c38dfe32de3420c239
Publikováno v:
Journal of Exercise & Organ Cross Talk, Vol 3, Iss 2, Pp 93-98 (2023)
High-intensity exercise training is one of the effective strategies to improve the performance of athletes to achieve excellent physical fitness. In the meantime, a look at the history of sports immunology reveals the idea of window theory, which has
Externí odkaz:
https://doaj.org/article/d7ae8e7dbcd1472782c2d2cf75e39091