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Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 51-67 (2021)
To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptid
Externí odkaz:
https://doaj.org/article/11b9a0cd871e48e387d597087364a932
Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 51-67 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 51-67 (2021)
To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2da5e803512b23e94334baf48cd0543
https://pubmed.ncbi.nlm.nih.gov/34553002
https://pubmed.ncbi.nlm.nih.gov/34553002
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