Zobrazeno 1 - 10
of 174
pro vyhledávání: '"mesoangioblast"'
Autor:
Francesco Galli, Laricia Bragg, Maira Rossi, Daisy Proietti, Laura Perani, Marco Bacigaluppi, Rossana Tonlorenzi, Tendai Sibanda, Miriam Caffarini, Avraneel Talapatra, Sabrina Santoleri, Mirella Meregalli, Beatriz Bano-Otalora, Anne Bigot, Irene Bozzoni, Chiara Bonini, Vincent Mouly, Yvan Torrente, Giulio Cossu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 927-944 (2024)
Abstract Cell therapy for muscular dystrophy has met with limited success, mainly due to the poor engraftment of donor cells, especially in fibrotic muscle at an advanced stage of the disease. We developed a cell-mediated exon skipping that exploits
Externí odkaz:
https://doaj.org/article/2901b421c44741348f703c80bba345e6
Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 51-67 (2021)
To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptid
Externí odkaz:
https://doaj.org/article/11b9a0cd871e48e387d597087364a932
Akademický článek
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Publikováno v:
Cells, Vol 11, Iss 10, p 1707 (2022)
Successful neuroprotection is only possible with contemporary microvascular protection. The prevention of disease-induced vascular modifications that accelerate brain damage remains largely elusive. An improved understanding of pericyte (PC) signalli
Externí odkaz:
https://doaj.org/article/5e4df8d37a004396b140a5c9340bde5f
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Myotonic dystrophy type 1 (DM1) and 2 (DM2) are autosomal dominant degenerative neuromuscular disorders characterized by progressive skeletal muscle weakness, atrophy, and myotonia with progeroid features. Although both DM1 and DM2 are characterized
Externí odkaz:
https://doaj.org/article/7a98fbe2e1554c15b810574a2a564fc3
Autor:
Giulio Cossu, Stefano C Previtali, Sara Napolitano, Maria Pia Cicalese, Francesco Saverio Tedesco, Francesca Nicastro, Maddalena Noviello, Urmas Roostalu, Maria Grazia Natali Sora, Marina Scarlato, Maurizio De Pellegrin, Claudia Godi, Serena Giuliani, Francesca Ciotti, Rossana Tonlorenzi, Isabella Lorenzetti, Cristina Rivellini, Sara Benedetti, Roberto Gatti, Sarah Marktel, Benedetta Mazzi, Andrea Tettamanti, Martina Ragazzi, Maria Adele Imro, Giuseppina Marano, Alessandro Ambrosi, Rossana Fiori, Maria Pia Sormani, Chiara Bonini, Massimo Venturini, Letterio S Politi, Yvan Torrente, Fabio Ciceri
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 12, Pp 1513-1528 (2015)
Abstract Intra‐arterial transplantation of mesoangioblasts proved safe and partially efficacious in preclinical models of muscular dystrophy. We now report the first‐in‐human, exploratory, non‐randomized open‐label phase I–IIa clinical tr
Externí odkaz:
https://doaj.org/article/94c76682216f4ec1906181c0408f9d96
Autor:
Kenichi Watanabe, Masazumi Kamohara, Shigeru Miyagawa, Masao Sasai, Kazuhiko Mizukami, Hiromu Sato, Yoshiki Sawa, Kenichiro Shimatani, Atsuhiro Saito
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H1124-H1135
Critical limb ischemia (CLI) is a severe state of peripheral artery disease with high unmet clinical needs. Further, there are no effective treatment options for patients with CLI. Based on preclinical study results, predicting the clinical efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2461053c5117257d87745b806ae6c4
https://doi.org/10.1152/ajpheart.00470.2020
https://doi.org/10.1152/ajpheart.00470.2020
Publikováno v:
Stem Cell Reviews and Reports, 17, 878-899
Stem Cell Reviews and Reports, 17, 3, pp. 878-899
Stem Cell Reviews and Reports, 17, 3, pp. 878-899
The intrinsic regenerative capacity of skeletal muscle makes it an excellent target for cell therapy. However, the potential of muscle tissue to renew is typically exhausted and insufficient in muscular dystrophies (MDs), a large group of heterogeneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216b717e5c06e522e316b898b4adb377
https://doi.org/10.1007/s12015-020-10100-y
https://doi.org/10.1007/s12015-020-10100-y
Publikováno v:
Stem Cell Reviews and Reports
Graphical abstract The intrinsic regenerative capacity of skeletal muscle makes it an excellent target for cell therapy. However, the potential of muscle tissue to renew is typically exhausted and insufficient in muscular dystrophies (MDs), a large g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::963394340e94a73072d16aceeff5a6ff
http://europepmc.org/articles/PMC8166694
http://europepmc.org/articles/PMC8166694
Akademický článek
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