Zobrazeno 1 - 10
of 1 551
pro vyhledávání: '"mesenchymal transformation"'
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Endothelial-mesenchymal transformation (EndoMT) is the process through which endothelial cells transform into mesenchymal cells, affecting their morphology, gene expression, and function. EndoMT is a potential risk factor for cardiovascular
Externí odkaz:
https://doaj.org/article/00e82e7da3fe43648623e2187c74eb2f
Autor:
Weihong Chen, Mingyuan Chen, Lingju Hong, Abudukeremu Xiahenazi, Maotuan Huang, Nanhong Tang, Xinyue Yang, Feifei She, Yanling Chen
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract Background The predominant immune cells in solid tumors are M2-like tumor-associated macrophages (M2-like TAMs), which significantly impact the promotion of epithelial-mesenchymal transition (EMT) in tumors, enhancing stemness and facilitati
Externí odkaz:
https://doaj.org/article/87f4d6cbd0214a18ac9955a8afb48606
Publikováno v:
International Journal of General Medicine, Vol Volume 17, Pp 3433-3442 (2024)
Jun Cao,1,2 Hao Zhang,2 Xin Xie,3 Wei Wang4 1Department of Oncology, The Third Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, 710061, People’s Republic of China; 2Department of Surgical Oncology, The First Affiliated Hospital
Externí odkaz:
https://doaj.org/article/593f59acd0e244f3b40cf7d586d410a6
Publikováno v:
环境与职业医学, Vol 41, Iss 6, Pp 687-693 (2024)
BackgroundCoal workers' pneumoconiosis (CWP) is a serious occupational lung disease and one of the prescript occupational diseases in China. Epithelial-mesenchymal transition (EMT) is involved in the diffuse fibrosis of lung tissue of pneumoconiosis
Externí odkaz:
https://doaj.org/article/e6263e5290c147ac85b5f474e275f81b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Pulmonary fibrosis is a progressive interstitial lung disease associated with aging. The pathogenesis of pulmonary fibrosis remains unclear, however, alveolar epithelial cell injury, myofibroblast activation, and extracellular matrix (ECM) accumulati
Externí odkaz:
https://doaj.org/article/283bc956314d45c1a8c7d219e1514320
Autor:
Renfei Du, Ahmed Y. Sanin, Wenjie Shi, Bing Huang, Ann-Christin Nickel, Andres Vargas-Toscano, Shuran Huo, Thomas Nickl-Jockschat, Claudia A. Dumitru, Wei Hu, Siyu Duan, I. Erol Sandalcioglu, Roland S. Croner, Joshua Alcaniz, Wolfgang Walther, Carsten Berndt, Ulf D. Kahlert
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Glioblastoma (GBM) is the most commonly occurring and most aggressive primary brain tumor. Transcriptomics-based tumor subtype classification has established the mesenchymal lineage of GBM (MES-GBM) as cancers with particular aggressive behavior and
Externí odkaz:
https://doaj.org/article/6f46caeb3c7e4375a3ce00e72c97f3d4
Autor:
Cunxiang Bo, Fang Liu, Zewen Zhang, Zhongjun Du, Haidi Xiu, Zhenling Zhang, Ming Li, Caiqing Zhang, Qiang Jia
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Simvastatin (Sim), a hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has been widely used in prevention and treatment of cardiovascular diseases. Studies have suggested that Sim exerts anti-fibrotic effects by int
Externí odkaz:
https://doaj.org/article/a52dd4f5df3c4d129270bda320f53129
Autor:
Xuedan Han, Hai Qin, Yu Lu, Haitao Chen, Zhengdong Yuan, Yiwen Zhang, Xuena Yang, Lufeng Zheng, Simin Yan
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34015- (2024)
While strides in cancer treatment continue to advance, the enduring challenges posed by cancer metastasis and recurrence persist as formidable contributors to the elevated mortality rates observed in cancer patients. Among the multifaceted factors im
Externí odkaz:
https://doaj.org/article/7cc3b67e066a497ab809e9c991994f55
Autor:
Yue Wang, Ying Li, Liang Wang, Buze Chen, Miaolin Zhu, Chunyi Ma, Chunyan Mu, Aibin Tao, Shibao Li, Lan Luo, Ping Ma, Shuai Ji, Ting Lan
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/6c3e4bd35f224880965f65cfb5066c7f
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background and purpose Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. Its role in cancer metastasis remains unclear. In this study, we aimed to investigate the potential involvement of ferro
Externí odkaz:
https://doaj.org/article/b10013bd47db4f81915be3522b0ecbd0