Zobrazeno 1 - 10
of 565
pro vyhledávání: '"meprin"'
Autor:
Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Targeting metalloproteinases has been in the focus of drug design for a long time. However, meprin α and β emerged as potential drug targets just recently and are linked to several diseases with different pathological background. Nevertheless, the
Externí odkaz:
https://doaj.org/article/6cf1ad89dd504526bad8c27cce359ded
Akademický článek
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Autor:
Birte Wöhner, Wenjia Li, Sven Hey, Alice Drobny, Ludwig Werny, Christoph Becker-Pauly, Ralph Lucius, Friederike Zunke, Stefan Linder, Philipp Arnold
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The cell surface receptor cluster of differentiation 44 (CD44) is the main hyaluronan receptor of the human body. At the cell surface, it can be proteolytically processed by different proteases and was shown to interact with different matrix metallop
Externí odkaz:
https://doaj.org/article/c16d6303b6494ddd8edfb4c2557380da
Publikováno v:
Physiological Reports, Vol 10, Iss 18, Pp n/a-n/a (2022)
Abstract Meprin metalloproteinases have been implicated in the pathophysiology of ischemia/reperfusion (IR)‐induced kidney injury. Previous in vitro data showed that meprin β proteolytically processes interleukin‐6 (IL‐6) resulting in its inac
Externí odkaz:
https://doaj.org/article/9a7ed1b479d44b3a83c334a77731ed95
Autor:
Antonin Gellrich, Franka Scharfenberg, Florian Peters, Martin Sammel, Ole Helm, Fred Armbrust, Frederike Schmidt, Juliane Lokau, Christoph Garbers, Susanne Sebens, Philipp Arnold, Christoph Becker-Pauly
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Meprin β is a metalloprotease associated with neurodegeneration, inflammation, extracellular matrix homeostasis, transendothelial cell migration, and cancer. In this study, we investigated two melanoma-associated variants of meprin β, both exhibiti
Externí odkaz:
https://doaj.org/article/c636de579977474cbd0a52a9602e4edc
Autor:
Jessica Gooding, Lei Cao, Courtney Whitaker, Jean-Marie Mwiza, Mizpha Fernander, Faihaa Ahmed, Zach Acuff, Susan McRitchie, Susan Sumner, Elimelda Moige Ongeri
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-18 (2019)
Abstract Background Meprin metalloproteases are abundantly expressed in the brush border membranes of kidney proximal tubules and small intestines. Meprins are also expressed in podocytes and leukocytes (monocytes and macrophages). Meprins are implic
Externí odkaz:
https://doaj.org/article/532c8128eae745d486d4c4df41ccc9b8
Autor:
Wiebke Lückstädt, Simon Bub, Tomas Koudelka, Egor Pavlenko, Florian Peters, Prasath Somasundaram, Christoph Becker-Pauly, Ralph Lucius, Friederike Zunke, Philipp Arnold
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cluster of differentiation 109 (CD109) is a glycosylphosphatidylinositol (GPI)-anchored protein expressed on primitive hematopoietic stem cells, activated platelets, CD4+ and CD8+ T cells, and keratinocytes. In recent years, CD109 was also associated
Externí odkaz:
https://doaj.org/article/127babcb07f449938ff43b5a135b962c
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Chao Wang, Juan Diez, Hajeung Park, Christoph Becker-Pauly, Gregg B. Fields, Timothy P. Spicer, Louis D. Scampavia, Dmitriy Minond, Thomas D. Bannister
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 197 (2021)
Meprin α is a zinc metalloproteinase (metzincin) that has been implicated in multiple diseases, including fibrosis and cancers. It has proven difficult to find small molecules that are capable of selectively inhibiting meprin α, or its close relati
Externí odkaz:
https://doaj.org/article/d8cceaa6cbc14f5f907dec89399d1671
Autor:
Shurong Hou, Juan Diez, Chao Wang, Christoph Becker-Pauly, Gregg B. Fields, Thomas Bannister, Timothy P. Spicer, Louis D. Scampavia, Dmitriy Minond
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 203 (2021)
Meprin α and β are zinc-dependent proteinases implicated in multiple diseases including cancers, fibrosis, and Alzheimer’s. However, until recently, only a few inhibitors of either meprin were reported and no inhibitors are in preclinical develop
Externí odkaz:
https://doaj.org/article/126fee70a926458eba6f3c82eced1816