Zobrazeno 1 - 10
of 1 320
pro vyhledávání: '"menin"'
Autor:
Troka, Ildi1 ildi.troka@mail.mcgill.ca, Griffanti, Gabriele2 gabriele.griffanti@mail.mcgill.ca, Canaff, Lucie3 lucie.canaff@gmail.com, Hendy, Geoffrey N.3 david.goltzman@mcgill.ca, Goltzman, David3, Nazhat, Showan N.2 showan.nazhat@mcgill.ca
Publikováno v:
Biomimetics (2313-7673). Sep2022, Vol. 7 Issue 3, p101-101. 12p.
Autor:
Anna Candoni, Gabriele Coppola
Publikováno v:
Hematology Reports, Vol 16, Iss 2, Pp 244-254 (2024)
Menin inhibitors are new and promising agents currently in clinical development that target the HOX/MEIS1 transcriptional program which is critical for leukemogenesis in histone-lysine N-methyltransferase 2A-rearranged (KMT2Ar) and in NPM1-mutated (N
Externí odkaz:
https://doaj.org/article/7cc63b2b6a454a1684d46c256dd600f1
Autor:
Zhuo-Yu An, Xiao-Hui Zhang
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-3 (2024)
Abstract Recent developments in menin inhibitors for relapsed or refractory acute myeloid leukemia (AML) were highlighted at the 2023 ASH Annual Meeting. Notably, revumenib showed promising efficacy, achieving a 100% ORR when combined with decitabine
Externí odkaz:
https://doaj.org/article/4cde5c158b4e4b5980ee9cc25eb79e53
Autor:
Xavier Thomas
Publikováno v:
Oncology and Therapy, Vol 12, Iss 1, Pp 57-72 (2024)
Abstract Recent advances have included insights into the clinical value of genomic abnormalities in acute myeloid leukemia (AML) and consequently the development of numerous targeted therapeutic agents that have improved clinical outcome. In this set
Externí odkaz:
https://doaj.org/article/aed9e4de3a734e0aab9eb96e48d4c8c5
Autor:
Wylie, Diana1
Publikováno v:
H-Net Reviews in the Humanities & Social Sciences. May2024, p1-4. 4p.
Autor:
Kai Zhuang, Lige Leng, Xiao Su, Shuzhong Wang, Yuemin Su, Yanbing Chen, Ziqi Yuan, Liu Zi, Jieyin Li, Wenting Xie, Sihan Yan, Yujun Xia, Han Wang, Huifang Li, Zhenyi Chen, Tifei Yuan, Jie Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract FOXG1 syndrome is a developmental encephalopathy caused by FOXG1 (Forkhead box G1) mutations, resulting in high phenotypic variability. However, the upstream transcriptional regulation of Foxg1 expression remains unclear. This report demonst
Externí odkaz:
https://doaj.org/article/c1a83ae33b844fd788e5860c5cadf9a4
Autor:
Qing Ling, Yutong Zhou, Yu Qian, Jiejing Qian, Yi Zhang, Jinghan Wang, Yanan Zhu, Yile Zhou, Juying Wei, Chunmei Yang, Jie Sun, Wenjuan Yu, Jie Jin, Xiang Zhang
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-5 (2023)
Abstract KMT2A-rearranged acute myeloid leukemia (KMT2Ar-AML) is an aggressive subtype of AML with poor response and prognosis. KMT2Ar-AML has been demonstrated to be sensitive to BCL2 inhibitor venetoclax (VEN), but these patients are unable to bene
Externí odkaz:
https://doaj.org/article/fe5effd15134428ebe2d2d07aff7ef4f
Autor:
Xu, Shilin1, Aguilar, Angelo1, Xu, Tianfeng1, Zheng, Ke1, Huang, Liyue1, Stuckey, Jeanne2, Chinnaswamy, Krishnapriya2, Bernard, Denzil1, Fernández‐salas, Ester3, Liu, Liu1, Wang, Mi1, Mceachern, Donna1, Przybranowski, Sally1, Foster, Caroline1, Wang, Shaomeng1 shaomeng@umich.edu
Publikováno v:
Angewandte Chemie. 2/5/2018, Vol. 130 Issue 6, p1617-1621. 5p.
Akademický článek
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Autor:
Lige Leng, Kai Zhuang, Hui Lin, Jinjun Ding, Shangchen Yang, Ziqi Yuan, Changquan Huang, Guimiao Chen, Zhenlei Chen, Mengdan Wang, Han Wang, Hao Sun, Huifang Li, He Chang, Zhenyi Chen, Qi Xu, Tifei Yuan, Jie Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Dysfunction of parvalbumin (PV) neurons is closely involved in depression, however, the detailed mechanism remains unclear. Based on the previous finding that multiple endocrine neoplasia type 1 (Protein: Menin; Gene: Men1) mutation (G503D)
Externí odkaz:
https://doaj.org/article/5308c172665341dc83ed94e76369fa4e