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Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens

Autor: Oscar P. Kuipers, Manuel Montalbán-López, Rubén Cebrián, Weihui Wu, Huan Ren, Qian Li

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications biology, 4(1):31. Nature Publishing Group
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Communications Biology

The development and dissemination of antibiotic-resistant bacterial pathogens is a growing global threat to public health. Novel compounds and/or therapeutic strategies are required to face the challenge posed, in particular, by Gram-negative bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef616bfabcac97a6615b816b053263eb
http://hdl.handle.net/10481/66691

ΔM4: Membrane-Active Peptide with Antitumoral Potential against Human Skin Cancer Cells

Autor: Estefanía Fandiño-Devia, Gloria A. Santa-González, Maria C. Klaiss-Luna, Ibeth Guevara-Lora, Verónica Tamayo, Marcela Manrique-Moreno

Publikováno v: Membranes, Vol 13, Iss 7, p 671 (2023)

Peptides have become attractive potential agents due to their affinity to cancer cells. In this work, the biological activity of the peptide ΔM4 against melanoma cancer cell line A375, epidermoid carcinoma cell line A431, and non-tumoral HaCaT cells

Externí odkaz: https://doaj.org/article/0e2864ab476a4471842212eb339b260f

Genetic grafting of membrane-acting peptides to the cytotoxin dianthin augments its ability to de-stabilize lipid bilayers and enhances its cytotoxic potential as the component of transferrin-toxin conjugates

Autor: Laura Costantini, Marco Colombatti, Giuseppe Tridente, Giulio Fracasso, G. Menestrina, E. Chiesa, Cristina Potrich, Irene Lorenzetti, Alessandra Meneguzzi, Giuseppe Legname

Three chimeric proteins were obtained by fusing together the dianthin gene and DNA fragments encoding for the following membrane-acting peptides: the N-terminus of protein G of the vesicular stomatitis virus (KFT25), the N terminus of the HA2 hemaggl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dda74394f4ab58a9d7cacaa4b5c485
http://hdl.handle.net/20.500.11767/16143

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