Zobrazeno 1 - 10
of 17 232
pro vyhledávání: '"mdm2"'
Autor:
Yumiko Miyazaki, Aina Yamaguchi, Hitomi Nanbu, Akiko Shinagawa, Mana Fukushima, Makoto Orisaka, Yoshio Yoshida
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 1229-1238 (2024)
Introduction: Uterine adenosarcoma (UA) is a rare malignant mesenchymal neoplasm characterized by benign epithelial and malignant stromal components. Comprehensive genomic profiling has identified a high frequency of murine double-minute type 2 (MDM2
Externí odkaz:
https://doaj.org/article/83a28196e14c4695808488979bd4263a
Autor:
Qinru Zeng, Shaocheng Zeng, Xiaofeng Dai, Yun Ding, Chunye Huang, Ruiwen Ruan, Jianping Xiong, Xiaomei Tang, Jun Deng
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101279- (2024)
Murine double minute 2 (MDM2) plays an essential role in the cell cycle, apoptosis, DNA repair, and oncogene activation through p53-dependent and p53-independent signaling pathways. Several preclinical studies have shown that MDM2 is involved in tumo
Externí odkaz:
https://doaj.org/article/5c3d035b07814623999d9ce31242e788
Autor:
Kosuke Kanno, Kentaro Nakayama, Sultana Razia, Sohel Hasibul Islam, Zahan Umme Farzana, Shahataj Begum Sonia, Hiroki Sasamori, Hitomi Yamashita, Tomoka Ishibashi, Masako Ishikawa, Kayo Imamura, Noriyoshi Ishikawa, Satoru Kyo
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 9, Pp 9376-9385 (2024)
Ovarian cancer is classified as type 1 or 2, representing low- and high-grade serous carcinoma (LGSC and HGSC), respectively. LGSC arises from serous borderline tumor (SBT) in a stepwise manner, while HGSC develops from serous tubal intraepithelial c
Externí odkaz:
https://doaj.org/article/deea19f6e3e644a599a7c33da57eb31d
Autor:
Wei Chen, Kai-Bin Yang, Yuan-Zhe Zhang, Zai-Shan Lin, Jin-Wei Chen, Si-Fan Qi, Chen-Fei Wu, Gong-Kan Feng, Da-Jun Yang, Ming Chen, Xiao-Feng Zhu, Xuan Li
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background High expression of ubiquitin ligase MDM2 is a primary cause of p53 inactivation in many tumors, making it a promising therapeutic target. However, MDM2 inhibitors have failed in clinical trials due to p53-induced feedback that enh
Externí odkaz:
https://doaj.org/article/36aa2479810046219abd7234f4f5e8a9
Autor:
Su Wang, Shufen Zhong, Ying Huang, Songling Zhu, Shuangfeng Chen, Ran Wang, Sonam Wangmo, Bo Peng, Houkun Lv, Jichao Yang, Liyan Ma, Zhiyang Ling, Yaguang Zhang, Pengfei Sui, Bing Sun
Publikováno v:
Journal of Innate Immunity, Vol 16, Iss 1, Pp 397-412 (2024)
Introduction: MDM2 is known as the primary negative regulator of p53, and MDM2 promotes lung cancer fibrosis and lung injury through p53-dependent and p53-independent pathways. However, the mechanism by which MDM2 influences the pathogenesis of asthm
Externí odkaz:
https://doaj.org/article/824f3d6dab2643d292de67f3612b2047
Autor:
Theresia Indah Budhy, Ira Arundina, Anis Irmawati, Sidarningsih, Meircurius Dwi Condro Surboyo, Cecillia Octavianni Raharjo, Ciptantyo Septyan Akbar, Malika Qadira Rahmalia
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 12, Iss 4, Pp 748-758 (2024)
Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and cancer development. Aucklandia costus Falc. or Saussurea lappa contains bioac
Externí odkaz:
https://doaj.org/article/82db1a0c3f874516a3afbf761a2dd277
Autor:
Jiajia Wang, Hui Liu, Zeyuan Yu, Qianqian Zhou, Feifei Sun, Jingying Han, Lin Gao, Baokai Dou, Hanwen Zhang, Jiawei Fu, Wenqiao Jia, Weiwen Chen, Jing Hu, Bo Han
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal. Characterization of mechanisms underlying aberrant AR pathway activation to search for pot
Externí odkaz:
https://doaj.org/article/53f2bb0e165443118786ddd413f4b43e
Autor:
Jiro Ichikawa, Tomonori Kawasaki, Kojiro Onohara, Satoshi Kanno, Masanori Wako, Satoshi Ochiai, Kaoru Aoki, Hirotaka Haro
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/cf8f356afcb94318aab2888ff11cbeee
Autor:
Wanyi Zou, Mengna Li, Shili Wan, Jingkun Ma, Linan Lian, Guanghao Luo, Yubo Zhou, Jia Li, Bing Zhou
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Protein arginine methyltransferase 3 (PRMT3) plays an important role in gene regulation and a variety of cellular functions, thus, being a long sought‐after therapeutic target for human cancers. Although a few PRMT3 inhibitors are develope
Externí odkaz:
https://doaj.org/article/43cce0493dd74279a4961bfa1c25e2ab
Autor:
حبيب السلوم
Publikováno v:
مجلة جامعة دمشق للعلوم الطبية, Vol 40, Iss 3 (2024)
خلفية البحث وهدفه: تلعب الأورام دورا" مؤثرا" على حياة الإنسان مما يتوجب تحريها وتشخيصها مبكرا" لنستطيع تجنبها والحصول على العلاج المناسب
Externí odkaz:
https://doaj.org/article/d1ac20d9db7e4059898881010435aa30