Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate

Autor: Willemieke M. Kouwenhoven, Lars von Oerthel, Maria Gruppilo, Jianmin Tian, Cindy M. R. J. Wagemans, Imke G. J. Houwers, Joseph Locker, Simone Mesman, Marten P. Smidt

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 23, p 12663 (2021)

Nkx2.9 is a member of the NK homeobox family and resembles Nkx2.2 both in homology and expression pattern. However, while Nkx2.2 is required for development of serotonergic neurons, the role of Nkx2.9 in the mid-hindbrain region is still ill-defined.

Externí odkaz: https://doaj.org/article/283aba92b0534e03b7fabca0de5e27a2

Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function

Autor: Willemieke M. Kouwenhoven, Jesse V. Veenvliet, Johannes A. van Hooft, L. P. van der Heide, Marten P. Smidt

Publikováno v: Biology Open, Vol 5, Iss 3, Pp 279-288 (2016)

The isthmic organizer (IsO) is a signaling center that specifies the correct and distinct embryonic development of the dopaminergic midbrain and serotonergic hindbrain. The IsO is a linear boundary between the two brain regions, emerging at around em

Externí odkaz: https://doaj.org/article/f8c0239564b747a5bec0b856fbc89d01

Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate

Autor: Simone Mesman, Imke G. J. Houwers, Lars von Oerthel, Jianmin Tian, Willemieke M. Kouwenhoven, Marten P. Smidt, Maria Gruppilo, Cindy M. R. J. Wagemans, Joseph Locker

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12663, p 12663 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 22(23):12663. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12663

Nkx2.9 is a member of the NK homeobox family and resembles Nkx2.2 both in homology and expression pattern. However, while Nkx2.2 is required for development of serotonergic neurons, the role of Nkx2.9 in the mid-hindbrain region is still ill-defined.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80361e9c0fb3b0cfa55ad1e4ceb2273
https://doi.org/10.3390/ijms222312663

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Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function

Autor: L. P. van der Heide, Jesse V. Veenvliet, Willemieke M. Kouwenhoven, Marten P. Smidt, Johannes A. van Hooft

Publikováno v: Biology Open, 5(3), 279-288. Company of Biologists Ltd
Biology Open, Vol 5, Iss 3, Pp 279-288 (2016)
Biology Open

The isthmic organizer (IsO) is a signaling center that specifies the correct and distinct embryonic development of the dopaminergic midbrain and serotonergic hindbrain. The IsO is a linear boundary between the two brain regions, emerging at around em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c8477bff462fdbd48eb59fafa7d5c2
https://doi.org/10.1242/bio.015032