Zobrazeno 1 - 10
of 1 834
pro vyhledávání: '"matrix stiffness"'
Autor:
Axel Stoecker, Diana Pinkert-Leetsch, Timea Koch, Roland Ackermann, Stefan Nolte, Christian van Oterendorp, Christoph Russmann, Jeannine Missbach-Guentner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Stiffness-related eye diseases such as keratoconus require comprehensive visualization of the complex morphological matrix changes. The aim of this study was to use three-dimensional (3D) light sheet fluorescence microscopy (LSFM) to analyze
Externí odkaz:
https://doaj.org/article/fc9781a323e9493f9d5cfa4078012df6
Autor:
Yang Shen, Jiayu Chen, Zhuolin Zhou, Jingyu Wu, Xinyao Hu, Yangtao Xu, Jiayi Li, Ling Wang, Siyu Wang, Shuhong Yu, Ling Feng, Ximing Xu
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Background In hepatocellular carcinoma (HCC) treatment, first-line targeted therapy in combination with immune checkpoint inhibitors (ICIs) has improved patient prognosis, but the 5-year survival rate is far from satisfactory. Studies have s
Externí odkaz:
https://doaj.org/article/79451d7af2d6417692184e0da9fb96bc
Publikováno v:
Radiation Oncology, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background The stiffness of the tumor microenvironment (TME) directly influences cellular behaviors. Radiotherapy (RT) is a common treatment for solid tumors, but the TME can impact its efficacy. In the case of liver cancer, clinical observa
Externí odkaz:
https://doaj.org/article/859dcc3d5fce4532b2feab2fe947c091
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The physical characteristics of the tumor microenvironment (TME) include solid stress, interstitial fluid pressure, tissue stiffness and microarchitecture. Among them, abnormal changes in tissue stiffness hinder drug delivery, inhibit infiltration of
Externí odkaz:
https://doaj.org/article/206375bef1bd436d90321f2c09d2720c
Publikováno v:
European Cells & Materials, Vol 47, Pp 253-264 (2024)
In the field of bone tissue engineering, scaffold materials play a central role in restoring and regenerating the physiological function of the skeletal system. Mechanical signals in the cellular microenvironment significantly influence cellular beha
Externí odkaz:
https://doaj.org/article/68f54f6f5b904e9d9d5b06db6c8394f1
Autor:
Jing Na, Zhijie Yang, Qiusheng Shi, Chiyu Li, Yu Liu, Yaxin Song, Xinyang Li, Lisha Zheng, Yubo Fan
Publikováno v:
Bioactive Materials, Vol 35, Iss , Pp 549-563 (2024)
The biophysical factors of biomaterials such as their stiffness regulate stem cell differentiation. Energy metabolism has been revealed an essential role in stem cell lineage commitment. However, whether and how extracellular matrix (ECM) stiffness r
Externí odkaz:
https://doaj.org/article/471db653544343119958dc09172e992b
Autor:
Alessandro Mancini, Maria Teresa Gentile, Francesca Pentimalli, Salvatore Cortellino, Michele Grieco, Antonio Giordano
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial in the processes of cell differentiation and proliferation. However, it is unclear to what extent tumor cells are influenced by biomechanical and biophysical c
Externí odkaz:
https://doaj.org/article/57d8abfed09443db8a6a0110e266d64c
Autor:
Jiaqiang Xiong, Rourou Xiao, Jiahui Zhao, Qiuyan Zhao, Manwen Luo, Feng Li, Wei Zhang, Meng Wu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) function is regulated by matrix stiffness in solid tumors and is
Externí odkaz:
https://doaj.org/article/496ee1470ca448998ee427bad2d5735e
Autor:
Shenghui Kang, Xiaoyu Wu, Hang Qi, Kai Yang, Ruoyu Feng, Wenlan Guo, Chen Sun, Xuexin Duan, Yanyan Wang
Publikováno v:
Small Structures, Vol 5, Iss 5, Pp n/a-n/a (2024)
Development of a micromodel that recapitulates multiple mechanical properties to mimic the complex mechanical microenvironment is crucial for cell‐based research. Herein, a microsystem combining structure of hydrogel matrix and acoustic streaming (
Externí odkaz:
https://doaj.org/article/93c8708efdad47989d34fe455cbf7ebe
Autor:
Xiangting Fu, Ali Taghizadeh, Mohsen Taghizadeh, Cheng Ji Li, Nam Kyu Lim, Jung‐Hwan Lee, Hye Sung Kim, Hae‐Won Kim
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Pathological dermal scars such as keloids present significant clinical challenges lacking effective treatment options. Given the distinctive feature of highly stiffened scar tissues, deciphering how matrix mechanics regulate pathological pro
Externí odkaz:
https://doaj.org/article/4f09ac006026481e99c86fe032a98ad6