Zobrazeno 1 - 10
of 444
pro vyhledávání: '"marimastat"'
Autor:
Akshatha N. Srinivas, Diwakar Suresh, Prashant M. Vishwanath, Suchitha Satish, Prasanna K. Santhekadur, Saisudha Koka, Divya P. Kumar
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1940-1957 (2024)
Metabolic dysfunction‐associated steatohepatitis‐driven hepatocellular carcinoma (MASH‐HCC) is a global clinical challenge for which there is a limited understanding of disease pathogenesis and a subsequent lack of therapeutic interventions. We
Externí odkaz:
https://doaj.org/article/a307303c0e544c5a8ff9b0d9ad67733c
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ricarda Plümers, Christopher Lindenkamp, Michel Robin Osterhage, Cornelius Knabbe, Doris Hendig
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 672 (2023)
Ectopic calcification and dysregulated extracellular matrix remodeling are prominent hallmarks of the complex heterogenous pathobiochemistry of pseudoxanthoma elasticum (PXE). The disease arises from mutations in ABCC6, an ATP-binding cassette transp
Externí odkaz:
https://doaj.org/article/2d5ff3854afc4a538e2d737feaef3f91
Autor:
Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1835-1845 (2020)
Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific p
Externí odkaz:
https://doaj.org/article/61d3b6b1ec4647a09b7106d2b3c0676a
Autor:
Abhinandan Chowdhury, Matthew R. Lewin, Rebecca Carter, Raul Soria, Matt Aldridge, Bryan G. Fry
Publikováno v:
Toxins, Vol 14, Iss 12, p 836 (2022)
The African viperid snake genera Atheris, Cerastes, and Proatheris are closely related, similar in size, but occupy extremely divergent ecological niches (arboreal in tropical rainforests, fossorial in deserts, and swamp-dwelling, respectively). Thei
Externí odkaz:
https://doaj.org/article/ab238764fab64504a8027d72c2b36d8c
Autor:
Arif Arrahman, Taline D. Kazandjian, Kristina B. M. Still, Julien Slagboom, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool
Publikováno v:
Toxins, Vol 14, Iss 11, p 736 (2022)
Envenomation by elapid snakes primarily results in neurotoxic symptoms and, consequently, are the primary focus of therapeutic research concerning such venoms. However, mounting evidence suggests these venoms can additionally cause coagulopathic symp
Externí odkaz:
https://doaj.org/article/5c1b8f5d1d7b4c71865060f67e731bd9
Autor:
Johannes Maximilian Wagner, Felix Reinkemeier, Christoph Wallner, Mehran Dadras, Stephanie Dittfeld, Marius Drysch, Alexander Sogorski, Maxi von Glinski, Marcus Lehnhardt, Björn Behr, Mustafa Becerikli
Publikováno v:
Life, Vol 12, Iss 2, p 134 (2022)
Patients with diabetes suffer from poor fracture healing. Molecular reasons are not fully understood and our previous gene expression microarray analyses of regenerating bones from mice with type 2 diabetes (db−/db−) revealed accelerated activati
Externí odkaz:
https://doaj.org/article/6a07295f57ec4ae4839a67cf51eb1d32
Autor:
Taline D. Kazandjian, Arif Arrahman, Kristina B. M. Still, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Mark C. Wilkinson, Jeroen Kool
Publikováno v:
Toxins, Vol 13, Iss 5, p 302 (2021)
Bites from elapid snakes typically result in neurotoxic symptoms in snakebite victims. Neurotoxins are, therefore, often the focus of research relating to understanding the pathogenesis of elapid bites. However, recent evidence suggests that some ela
Externí odkaz:
https://doaj.org/article/db8d99bd5e744e5c9a2b7c1cbd303297
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Chunfang Xie, Laura-Oana Albulescu, Mátyás A. Bittenbinder, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool
Publikováno v:
Biomedicines, Vol 8, Iss 9, p 297 (2020)
Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebit
Externí odkaz:
https://doaj.org/article/c97062d3079241948981e02b1bec328d