Zobrazeno 1 - 10
of 284
pro vyhledávání: '"marco giovannini"'
Autor:
Shilpa Prabhakar, Roberta L. Beauchamp, Pike See Cheah, Akiko Yoshinaga, Edwina Abou Haidar, Sevda Lule, Gayathri Mani, Katia Maalouf, Anat Stemmer-Rachamimov, David H. Jung, D. Bradley Welling, Marco Giovannini, Scott R. Plotkin, Casey A. Maguire, Vijaya Ramesh, Xandra O. Breakefield
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101262- (2024)
Externí odkaz:
https://doaj.org/article/3e5ab6a0da2740adbac015462c8c83b4
Autor:
Brian Na, Blake Haist, Shilp R. Shah, Graeme Sabiston, Steven J. Jonas, Jeremie Vitte, Richard E. Wirz, Marco Giovannini
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1986 (2024)
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder resulting from mutations in the NF1 gene. Patients harboring these mutations are predisposed to a spectrum of peripheral nerve sheath tumors (PNSTs) originating from Schwann cells, of w
Externí odkaz:
https://doaj.org/article/3f901916f71d4f779f1172116037a70f
Autor:
Christine Chiasson-MacKenzie, Jeremie Vitte, Ching-Hui Liu, Emily A. Wright, Elizabeth A. Flynn, Shannon L. Stott, Marco Giovannini, Andrea I. McClatchey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Schwannomas are mainly caused by NF2 tumour suppressor inactivation, but they display intratumoural heterogeneity. Here the authors show that this heterogeneity is caused by the loss of polarity and acquisition of different programmes of ErbB ligand
Externí odkaz:
https://doaj.org/article/910ca0cc6a5e4813874a61e9dbcdad7c
Autor:
Pasquale Niscola, Valentina Gianfelici, Marco Giovannini, Daniela Piccioni, Carla Mazzone, Paolo de Fabritiis
Publikováno v:
Cancers, Vol 16, Iss 8, p 1563 (2024)
Myelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. Molecular alterations in the hematopoietic stem cell compartment drive disease pathogenesis. Recent advancements in ge
Externí odkaz:
https://doaj.org/article/7d0dc25624724c0f9c5344ae790ece71
Autor:
Pasquale Niscola, Carla Mazzone, Nicolina Rita Ardu, Laura Cesini, Marco Giovannini, Stefano Fratoni, Paolo de Fabritiis
Publikováno v:
HemaSphere, Vol 7, p e4005998 (2023)
Externí odkaz:
https://doaj.org/article/2b2fe38144bd49a1b4f80e3ab6bea7f1
Autor:
Shilpa Prabhakar, Roberta L. Beauchamp, Pike See Cheah, Akiko Yoshinaga, Edwina Abou Haidar, Sevda Lule, Gayathri Mani, Katia Maalouf, Anat Stemmer-Rachamimov, David H. Jung, D. Bradley Welling, Marco Giovannini, Scott R. Plotkin, Casey A. Maguire, Vijaya Ramesh, Xandra O. Breakefield
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 169-180 (2022)
Loss of function of the neurofibromatosis type 2 (NF2) tumor suppressor gene leads to the formation of schwannomas, meningiomas, and ependymomas, comprising ∼50% of all sporadic cases of primary nervous system tumors. NF2 syndrome is an autosomal d
Externí odkaz:
https://doaj.org/article/7beaec1f53b24b3a8b2e347e32d796ca
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at la
Externí odkaz:
https://doaj.org/article/1faf2971b5a4423bb8a856e7f90310eb
Autor:
Ansgar Zoch, Steffen Mayerl, Alexander Schulz, Thomas Greither, Lucien Frappart, Juliane Rübsam, Heike Heuer, Marco Giovannini, Helen Morrison
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0129151 (2015)
The tumour suppressor Merlin, encoded by the gene NF2, is frequently mutated in the autosomal dominant disorder neurofibromatosis type II, characterised primarily by the development of schwannoma and other glial cell tumours. However, NF2 is expresse
Externí odkaz:
https://doaj.org/article/cbc6acee73c948b6945b4d484b0cbff5
Autor:
Laura Scaramucci, Pasquale Niscola, Massimiliano Palombi, Andrea Tendas, Marco Giovannini, Paolo De Fabritiis
Publikováno v:
Turkish Journal of Hematology, Vol 33, Iss 1, Pp 77-78 (2016)
Externí odkaz:
https://doaj.org/article/03fd59b27e9b46f6b4080f9dfa62f28a
Autor:
David H. Gutmann, Marco Giovannini
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 4, Pp 279-290 (2002)
The neurofibromatoses represent two of the most common inherited tumor predisposition syndromes affecting the nervous system. Individuals with neurofibromatosis 1 (NF1) are prone to the development of astrocytomas and peripheral nerve sheath tumors w
Externí odkaz:
https://doaj.org/article/7663ab46a8724317b18ceb85088eeaff