Zobrazeno 1 - 10
of 59 120
pro vyhledávání: '"mapk/erk"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract This study aimed to investigate the effect and potential mechanism of evodiamine (EVO) on proliferation and apoptosis of nasopharyngeal carcinoma (NPC) cells. EVO inhibited proliferation, blocked cell cycle progression, and induced apoptosis
Externí odkaz:
https://doaj.org/article/dd9d35a2b116443c996e01e325c16baa
Publikováno v:
BMC Anesthesiology, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Ischemia-reperfusion (I/R) injury is a major factor in liver damage following hepatic resection and liver transplantation, with anesthetics demonstrating the ability to shield organs from this type of injury. Methods Hypoxia-reoxy
Externí odkaz:
https://doaj.org/article/dd21410411184ca7b3dd434bca210520
Autor:
Runhui Lu, Yafan Zhang, Ran Chen, Lian Li, Caihu Huang, Zihan Zhou, Yingting Cao, Hongyan Li, Junya Li, Yixin Zhang, Yanli Wang, Jian Huang, Xian Zhao, Jing Feng, Jianxiu Yu, Chunling Du
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 59, Iss , Pp 101082- (2025)
The KRAS/ERK pathway is crucial in cancer progression and chemotherapy resistance, yet its upstream regulatory mechanism remains elusive. We identified MSI2 as a new promoter of chemotherapy resistance in cancers. MSI2 directly binds to a specific cl
Externí odkaz:
https://doaj.org/article/f327cd41a7134e4dafa9e8d3e381f497
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMatrine is an alkaloid extracted from Sophorus beans of the legume family, and it has significant effects and a variety of pharmacological activities. Osteosarcoma(OS) is a common malignant bone tumor that is characterized by high incidence
Externí odkaz:
https://doaj.org/article/68aa7d16afd142aba1f5c59d119c5cc6
Autor:
Kai-Kai Zhang, Jian-Zheng Yang, Chang-Hao Cheng, Jia-Yuan Wan, Yu-Chuan Chen, He-Qi Zhou, De-Kai Zheng, Zhi-Xian Lan, Qiu-Hong You, Qi Wang, Jian Sun
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 280, Iss , Pp 116538- (2024)
Methamphetamine (Meth) is a potent psychostimulant with well-established hepatotoxicity. Gut microbiota-derived short-chain fatty acids (SCFAs) have been reported to yield beneficial effects on the liver. In this study, we aim to further reveal the m
Externí odkaz:
https://doaj.org/article/09ee134e29224333ab93c8b4a04aa628
Publikováno v:
Thoracic Cancer, Vol 15, Iss 4, Pp 327-338 (2024)
Abstract Background Triosephosphate isomerase 1 (TPI1), as a widely involved glycolytic enzyme, plays a significant role in glucose metabolism and is highly expressed in various tumors. However, its role in lung adenocarcinoma (LUAD) remains incomple
Externí odkaz:
https://doaj.org/article/c96da624e4b74ea89cd02424392adfac
Publikováno v:
Food Frontiers, Vol 5, Iss 1, Pp 160-173 (2024)
Abstract The compounds that promote calcium absorption and osteogenesis may have great potential in controlling adipogenesis and obesity. In this study, the glycosylated peptides–calcium chelate prepared from Crimson Snapper scale protein hydrolysa
Externí odkaz:
https://doaj.org/article/4abd81f1c1624b99945e7cde081d8815
Publikováno v:
Nefrología (English Edition), Vol 43, Iss , Pp 8-20 (2023)
Introduction and objectives: Acute kidney injury (AKI) is a common devastating complication characterized by an abrupt loss of renal function. It is of great significance to explore promising biomarkers for AKI treatment. Materials and methods: Here,
Externí odkaz:
https://doaj.org/article/91c131abfe304a03a5ffacf271cd7c35
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer remains poorly understood. Herein, we investigated the expression of CD147 in different breast cancer cell
Externí odkaz:
https://doaj.org/article/8292d293c49f4aaf93c95e8701321807
Publikováno v:
Cell Adhesion & Migration, Vol 17, Iss 1, Pp 20-34 (2023)
ABSTRACTThe effect of cathelicidin hCAP18/LL-37 in hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we confirmed that LL-37 expression enhanced endothelial-mesenchymal transition (EMT), migration and invasion in HCC cells. And the HER
Externí odkaz:
https://doaj.org/article/b9a3066a1fb04b3c9e1db6219d68fa46