Zobrazeno 1 - 10
of 2 516
pro vyhledávání: '"mao-b"'
Autor:
Amir Raza, Jitendra Chaudhary, Azmat Ali Khan, Mahaveer Singh, Deepak Kumar, Abdul Malik, Pankaj Wadhwa
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Background Neurodegenerative disorders (NDs), primarily affecting the elderly, are marked by complex pathophysiological processes and are projected to become the second leading cause of death. Parkinson’s disease (PD), one of the most comm
Externí odkaz:
https://doaj.org/article/01756644a09c4c099136acb9b3387d68
Autor:
Fabrizio Stocchi, Paolo Barone, Roberto Ceravolo, Maria Francesca De Pandis, Leonardo Lopiano, Nicola Modugno, Alessandro Padovani, Manuela Pilleri, Alessandro Tessitore, Mario Zappia
Publikováno v:
Annals of Medicine, Vol 56, Iss 1 (2024)
AbstractBackground Oral levodopa remains the mainstay of treatment for Parkinson’s disease (PD). However, as PD progresses, response to treatment may fluctuate. Managing fluctuations can be demanding for clinicians and patients. There is a paucity
Externí odkaz:
https://doaj.org/article/702afcd4a74a4f599a04d871df252cc2
Autor:
Ali Irfan, Ameer Fawad Zahoor, Yassir Boulaamane, Sadia Javed, Huma Hameed, Amal Maurady, Muhammed Tilahun Muhammed, Sajjad Ahmad, Aamal A. Al-Mutairi, Irum Shahzadi, Sami A. Al-Hussain, Magdi E. A. Zaki
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Monoamine oxidase B (MAO-B) plays a pivotal role in the deamination process of monoamines, encompassing crucial neurotransmitters like dopamine and norepinephrine. The heightened interest in MAO-B inhibitors emerged after the revelation that this enz
Externí odkaz:
https://doaj.org/article/312cfb2526f9428a906bf9a1a766e73d
Autor:
Pasquale D’Acunzo, Elentina K. Argyrousi, Jonathan M. Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N. Goulbourne, Ottavio Arancio, Efrat Levy
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer’s disease, in Down syndrome, and in mouse models of these conditions. We have previously shown
Externí odkaz:
https://doaj.org/article/152d303abcc5498582c312cac72d05ac
Autor:
Eduardo Suárez-González, Jesús Sandoval-Ramírez, Jorge Flores-Hernández, Alan Carrasco-Carballo
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9674-9691 (2023)
Ginkgo biloba (GB) extracts have been used in clinical studies as an alternative therapy for Alzheimer’s disease (AD), but the exact bioaction mechanism has not yet been elucidated. In this work, an in silico study on GB metabolites was carried out
Externí odkaz:
https://doaj.org/article/e209a2a5dba942739044e3c4fa3e8151
Autor:
Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 100-117 (2023)
Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine
Externí odkaz:
https://doaj.org/article/474848c2851c400e9f7f9cec71ca3915
Autor:
Nishikawa, Noriko a, ⁎, Hatano, Taku a, Nishioka, Kenya b, Ueno, Shin-Ichi a, Saiki, Shinji a, Nakamura, Ryota c, Yoritaka, Asako d, Ogawa, Takashi c, Shimo, Yasushi e, Sako, Wataru a, Shimura, Hideki b, Furukawa, Yoshiaki b, Kamei, Takanori f, Ishida, Takayuki f, Hattori, Nobutaka a
Publikováno v:
In Journal of the Neurological Sciences 15 June 2024 461
Autor:
Jin Sung Ahn, Chung Hyeon Lee, Xiang-Qian Liu, Kwang Woo Hwang, Mi Hyune Oh, So-Young Park, Wan Kyunn Whang
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1061 (2024)
This study aimed to provide scientific data on the anti-Alzheimer’s disease (AD) effects of phenolic compounds from Drynariae Rhizoma (DR) extract using a multi-component approach. Screening of DR extracts, fractions, and the ten phenolic compounds
Externí odkaz:
https://doaj.org/article/30921ef6c8e64b38a502bfdbdae98eeb
Autor:
Wuhyun Koh, C. Justin Lee
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/53917ec4373c41bb8d0e33f6fc657bfd
Autor:
Yen N. Diep, Hee Jung Park, Joon-Ho Kwon, Minh Tran, Hae Young Ko, Hanhee Jo, Jisu Kim, Jee-In Chung, Tai Young Kim, Dongwoo Kim, Jong Hee Chang, You Jung Kang, C. Justin Lee, Mijin Yun, Hansang Cho
Publikováno v:
Biomaterials Research, Vol 27, Iss 1, Pp 1-19 (2023)
Abstract Background Glial scar formation is a reactive glial response confining injured regions in a central nervous system. However, it remains challenging to identify key factors formulating glial scar in response to glioblastoma (GBM) due to compl
Externí odkaz:
https://doaj.org/article/32760ab156ad4f80bd86f612c085d2aa