Zobrazeno 1 - 10
of 196
pro vyhledávání: '"manumycin"'
Autor:
Shu-Mei Shen, Yun-Chang Xie, Li-Rong Tu, Miao-Er Wu, Yan-Min Wang, Chun-Hui Song, Yu-Hui Sun, Ming-He Luo
Publikováno v:
Marine Drugs, Vol 22, Iss 11, p 521 (2024)
Chemically investigating the marine-derived Streptomyces parvus 1268 led to the isolation of a new compound of carpatamide I (1). Subsequent genomic analysis identified its candidate biosynthetic gene cluster ctd of approximately 44 kb. In order to o
Externí odkaz:
https://doaj.org/article/7f2f192af40246929489519e71bc988a
Autor:
Anna Hagemann, Philipp Klemens Altrogge, Miriam Caroline Alice Kehrenberg, Daniel Diehl, Dominik Jung, Lea Weber, Hagen Sjard Bachmann
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Manumycin A is postulated to be a specific inhibitor against the farnesyltransferase (FTase) since this effect has been shown in 1993 for yeast FTase. Since then, plenty of studies investigated Manumycin A in human cells as well as in model organisms
Externí odkaz:
https://doaj.org/article/36c6124ce827486b9377adae9da51e0a
Publikováno v:
Czech Journal of Genetics and Plant Breeding, Vol 57, Iss 1, Pp 36-42 (2021)
The farnesyltransferase α-subunit (FTA) may be involved in the regulation of defence responses against pathogens in plants. In this study, this gene was amplified from Catharanthus roseus (CrFTA gene). The cDNA was found to be 1 403 bp long, and enc
Externí odkaz:
https://doaj.org/article/4b39f0d100154d0cbe5c4ee8230ebf15
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
It is now becoming well established that vesicles are released from a broad range of cell types and are involved in cell-to-cell communication, both in physiological and pathological conditions. Once outside the cell, these vesicles are termed extrac
Externí odkaz:
https://doaj.org/article/76d76d3446304414a12d267e0102af69
Akademický článek
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Autor:
Damian Robert Sojka, Sylwia Hasterok, Natalia Vydra, Agnieszka Toma-Jonik, Anna Wieczorek, Agnieszka Gogler-Pigłowska, Dorota Scieglinska
Publikováno v:
Cells, Vol 10, Iss 6, p 1418 (2021)
Manumycin A (MA) is a well-tolerated natural antibiotic showing pleiotropic anticancer effects in various preclinical in vitro and in vivo models. Anticancer drugs may themselves act as stressors to induce the cellular adaptive mechanism that can min
Externí odkaz:
https://doaj.org/article/fb79e1343cfe4a1497b8ebef0ee77518
Autor:
Dominika Gorniaková, Miroslav Petříček, David Kahoun, Roman Grabic, Tomáš Zelenka, Alica Chroňáková, Kateřina Petříčková
Publikováno v:
Microorganisms, Vol 9, Iss 3, p 559 (2021)
(1) Background: Manumycins are small actinomycete polyketides with prominent cancerostatic and immunosuppressive activities via inhibition of various eukaryotic enzymes. Their overall activity towards human cells depends on the structural variability
Externí odkaz:
https://doaj.org/article/974dbb7d34d94b2bb110be7c2ca4f772
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 3, Pp 1147-1156 (2016)
Background/Aims: The streptomycete derived farnesyltransferase inhibitor Manumycin A triggers apoptosis of tumor cells and is thus considered for the treatment of malignancy. The present study explored whether Manumycin A could similarly stimulate er
Externí odkaz:
https://doaj.org/article/36e9a7de0e7041d98a09b703eb37dec1
Akademický článek
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Autor:
Scott M. Brittain, Xiaoyou Liang, Mikiko Okumura, Lynn M. McGregor, Yosuke Isobe, Daniel K. Nomura, Thomas J. Maimone, Ross White, Markus Schirle, William C. Forrester, John A. Tallarico, Michael D. Jones, Jeffrey Mckenna
Publikováno v:
Nature chemical biology
Nature chemical biology, vol 16, iss 11
Nature chemical biology, vol 16, iss 11
Molecular glues are an intriguing therapeutic modality that harness small-molecules to induce interactions between proteins that typically do not interact. However, such molecules are rare and have been discovered fortuitously, thus limiting their po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f577f3d01eac85dac172deabf96fdda
http://europepmc.org/articles/PMC7572527
http://europepmc.org/articles/PMC7572527