Zobrazeno 1 - 10
of 1 632
pro vyhledávání: '"mammalian target of rapamycin mTOR"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Disruption of inhibitory interneurons is common in the epileptic brain and is hypothesized to play a pivotal role in epileptogenesis. Abrupt disruption and loss of interneurons is well-characterized in status epilepticus models of epilepsy, however,
Externí odkaz:
https://doaj.org/article/224eff835e1048a9a1fa3c42fe47ee04
Publikováno v:
Gastroenterology Insights, Vol 15, Iss 2, Pp 447-458 (2024)
The gut microbiota interacts with the host’s immune function, and evidence supports a relationship between the gut microbiota and age-related disease. Consumption of herbs and spices, which contain bioactive compounds such as polyphenols, is associ
Externí odkaz:
https://doaj.org/article/48a5abab81434a90a28cd55e999cd138
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
With the outbreak of the coronavirus disease 2019 (COVID-19), reductions in T-cell function and exhaustion have been observed in patients post-infection of COVID-19. T cells are key mediators of anti-infection and antitumor, and their exhaustion incr
Externí odkaz:
https://doaj.org/article/8335216134c342e0b8097ec7f29f41f3
Autor:
Masao Ryu, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Takeru Tsujimoto, Kunihiko Miyazaki, Hiroki Ohnishi, Tomoya Matsuo, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda, Kenichiro Kakutani
Publikováno v:
Cells, Vol 13, Iss 23, p 2030 (2024)
The mammalian target of rapamycin (mTOR), a serine/threonine kinase, promotes cell growth and inhibits autophagy. The following two complexes contain mTOR: mTORC1 with the regulatory associated protein of mTOR (RAPTOR) and mTORC2 with the rapamycin-i
Externí odkaz:
https://doaj.org/article/2c2946945e674ebba5f9a96aa48e8276
Autor:
Qiang Cai, Quazi T. H. Shubhra
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/7e306b5777514e498b433c112dd4fc83
Publikováno v:
Türk Biyokimya Dergisi, Vol 49, Iss 2, Pp 210-219 (2023)
The catalytic subunits of Class IA PI3K, p110α, p110β, and p110δ, phosphorylates phosphatidylinositol 4,5-bisphosphate (PIP2) into phosphatidylinositol 3,4,5-trisphosphate (PIP3) on the plasma membrane. In cancer, these catalytic subunits are usua
Externí odkaz:
https://doaj.org/article/b0ca61dcdf2c48818caa1e1ad34e250d
Autor:
JIA Nan, WANG Zhilian
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 11, Pp 1733-1737 (2023)
Calcium binding and coiled-coil domain 1 (CALCOCO1) is an autophagy regulatory protein being discovered in recent years, which plays an important role in selective autophagy process. The gene coding for autophagy is located at 12q13.13, and its codin
Externí odkaz:
https://doaj.org/article/621cefc93f0e4d3d8dc367c3ee05fd42
Autor:
Swaraj Sinha, Krishnaraju Venkata Alluri, Venkateswarlu Somepalli, Trimurtulu Golakoti, Krishanu Sengupta
Publikováno v:
Food & Nutrition Research, Vol 67, Pp 1-16 (2023)
Background: A proprietary combination of Garcinia mangostana fruit rind and Cinnamomum tamala leaf extracts (LI80020F4, CinDura®) improved the physical performance and muscle strength of resistance-trained adult males. Objective: This study assessed
Externí odkaz:
https://doaj.org/article/82f26d9d9a8445d09cfddb37b776504d
Autor:
Hai-tao Lu, Yuan-yuan Jiao, Tian-yu Yu, Jing-xuan Shi, Jing-wei Tian, Gu-ming Zou, Lin Liu, Li Zhuo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction:Diabetic kidney disease (DKD) necessitates innovative therapeutic strategies. This study delves into the role of DNA damage-inducing transcription factor 4 (DDIT4) within the VDR-mTOR pathway, aiming to identify a novel target for DKD dr
Externí odkaz:
https://doaj.org/article/de2aa03187af476ab8fa45a5ac03874f
Autor:
Peir-In Liang, Hong-Yue Lai, Ti-Chun Chan, Wei-Ming Li, Chung-Hsi Hsing, Steven K. Huang, Kun-Lin Hsieh, Wen-Hsin Tseng, Tzu-Ju Chen, Wan-Shan Li, Huan-Da Chen, Yu-Hsuan Kuo, Chien-Feng Li
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Dihydropyrimidinase-like 3 (DPYSL3) is a cytosolic phosphoprotein expressed in the nervous system and is crucial for neurogenesis. A previous study showed that increased DPYSL3 expression promotes tumour aggressiveness in pancreat
Externí odkaz:
https://doaj.org/article/39778566c92444fdb61b9cfb95990740