Výsledky vyhledávání - "major histocompatibility antigen class 1"

Epitope Prediction Assays Combined with Validation Assays Strongly Narrows down Putative Cytotoxic T Lymphocyte Epitopes

Autor: Peng Peng Ip, Hans W. Nijman, Toos Daemen

Publikováno v: Vaccines
Volume 3
Issue 2
Pages 203-220
Vaccines, 3(2), 203-220. MDPI AG
Vaccines, Vol 3, Iss 2, Pp 203-220 (2015)

Tumor vaccine design requires prediction and validation of immunogenic MHC class I epitopes expressed by target cells as well as MHC class II epitopes expressed by antigen-presenting cells essential for the induction of optimal immune responses. Epit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb257496d65414b5fc9a20e46ff9a26
https://doi.org/10.3390/vaccines3020203

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Architectural Insight into Inovirus-Associated Vectors (IAVs) and Development of IAV-Based Vaccines Inducing Humoral and Cellular Responses: Implications in HIV-1 Vaccines

Autor: Hassapis, K. A., Stylianou, Dora C., Kostrikis, Leontios G.

Publikováno v: Viruses, Vol 6, Iss 12, Pp 5047-5076 (2014)
Viruses

Inovirus-associated vectors (IAVs) are engineered, non-lytic, filamentous bacteriophages that are assembled primarily from thousands of copies of the major coat protein gp8 and just five copies of each of the four minor coat proteins gp3, gp6, gp7 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae16d66ea7c11aadd0c936516cf7292
http://www.mdpi.com/1999-4915/6/12/5047

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Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells

Autor: Juliana Idoyaga, Anthony J. Bonito, Ralph M. Steinman, Shin-ichiro Fujii, Yang Liu, Xue-Feng Bai, Rosa Wainstok, José Mordoh, Kang Liu, Anna Charalambous

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
J. Exp. Med. 2005;202(11):1507-1516
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
The Journal of Experimental Medicine

If irradiated tumor cells could be rendered immunogenic, they would provide a safe, broad, and patient-specific array of antigens for immunotherapies. Prior approaches have emphasized genetic transduction of live tumor cells to express cytokines, cos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0458919e09b84d5b6781edb3080eb39e
https://doi.org/10.1084/jem.20050956

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5-Fluorouracil–Based Chemotherapy Enhances the Antitumor Activity of a Thymidylate Synthase–Directed Polyepitopic Peptide Vaccine

Autor: Marzio Vestri, Enzo Bonmassar, Gianni Gori Savellini, Marco La Placa, Angelo Aquino, Guido Francini, Giorgio Giorgi, François Lemonnier, Giuseppa Di Genova, Renato Urso, Maria Teresa Del Vecchio, Pierpaolo Correale, Chiara Terrosi, Maria Grazia Cusi

Publikováno v: JNCI: Journal of the National Cancer Institute. 97:1437-1445

Background: Thymidylate synthase (TS), a key enzyme in DNA synthesis, is often overexpressed in cancer cells. Some chemotherapeutic agents, such as 5-fluorouracil (5-FU), act by inhibiting TS expression. We evaluated whether a novel 28-amino acid mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66226149c1aff4743befdd38750a9fe
https://doi.org/10.1093/jnci/dji188

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Characterising a Microsatellite for DRB Typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)

Autor: Manuel E. Patarroyo, Manuel A. Patarroyo, Carlos F. Suárez, Carolina López, Luis F. Cadavid

Publikováno v: PLoS ONE
Ward, J.M., Vallender, E.J., The resurgence and genetic implications of New World primates in biomedical research (2012) Trends Genet, 28, pp. 586-591
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
PLoS ONE, Vol 9, Iss 5, p e96973 (2014)

Non-human primates belonging to the Aotus genus have been shown to be excellent experimental models for evaluating drugs and vaccine candidates against malaria and other human diseases. The immune system of this animal model must be characterised to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b880513d84d03b412eb54b7c48906f
http://europepmc.org/articles/PMC4018467

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Entire genome of a strain of human immunodeficiency virus type 1 with a deletion of nef that was recovered 20 years after primary infection: Large pool of proviruses with deletions of env

Autor: Cartesio Favalli, Arrigo Benedetto, Graziella Calugi, Francesco Montella

We report the complete sequence analysis of the provirus harbored in a long-term nonprogressor (patient SG1) 20 years after the first infection with a human immunodeficiency virus type 1 strain lacking nef . The sequencing showed large deletions in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e42195c5c41f55bdc7005dc136899d3
http://hdl.handle.net/2108/34872

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Dendritic Cells Charged with Apoptotic Tumor Cells Induce Long-Lived Protective CD4+ and CD8+ T Cell Immunity against B16 Melanoma

Autor: Goldszmid, R.S., Idoyaga, J., Bravo, A.I., Steinman, R., Mordoh, J., Wainstok, R.

Publikováno v: J. Immunol. 2003;171(11):5940-5947
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Dendritic cells (DCs) are potent APCs and attractive vectors for cancer immunotherapy. Using the B16 melanoma, a poorly immunogenic experimental tumor that expresses low levels of MHC class I products, we investigated whether DCs loaded ex vivo with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::ca00b515d41674fd533a526e899851b2

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Immunogenicity of Intensively Decellularized Equine Carotid Arteries Is Conferred by the Extracellular Matrix Protein Collagen Type VI

Autor: Heiko Meyer, Falk F. R. Buettner, Ulrike Boeer, Mathias Wilhelmi, Georgios C. Antonopoulos, Axel Haverich, Melanie Klingenberg

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105964 (2014)
PLoS ONE
PLoS ONE 9 (2014), Nr. 8

The limited biocompatibility of decellularized scaffolds is an ongoing challenge in tissue engineering. Here, we demonstrate the residual immunogenicity of an extensively decellularized equine carotid artery (dEAC intens) and identify the involved im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff82508e0253572652d107a4dbf4145
https://doi.org/10.1371/journal.pone.0105964

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Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells

To evaluate the effectiveness of vaccine protection from infected cells from another individual of the same species, vaccinated rhesus macaques (Macaca mulatta) were challenged with peripheral blood mononuclear cells from another animal diagnosed wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::c32a24122985f3bec4d42c3ee5653bb1
http://resolver.tudelft.nl/uuid:6185b90b-df49-4bef-8b3f-a0e3dbda01be

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Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells

Autor: S. Norley, P de Vries, Rob Dubbes, M. Dings, P. J. F. Ten Haaft, M. Cranage, C van Els, A Osterhaus, Ronald E. Bontrop, Margreet Jonker, Jolande Boes, Nel Otting, Jonathan L. Heeney, Henk Niphuis, Wim Koornstra

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, 2, 180, 769-774

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3bbe8ae509869e8eeb289fb570591b
http://resolver.tudelft.nl/uuid:6185b90b-df49-4bef-8b3f-a0e3dbda01be

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