Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4

Autor: Belén García-Fojeda, Carlos M. Minutti, Carlos Montero-Fernández, Cordula Stamme, Cristina Casals

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Activation of tissue repair program in macrophages requires the integration of IL-4/IL-13 cytokines and tissue-specific signals. In the lung, surfactant protein A (SP-A) is a tissue factor that amplifies IL-4Rα-dependent alternative activation and p

Externí odkaz: https://doaj.org/article/492f046453784e8ea4d3dd1df2da687e

Extracellular Vesicles from a Helminth Parasite Suppress Macrophage Activation and Constitute an Effective Vaccine for Protective Immunity

Autor: Gillian Coakley, Jana L. McCaskill, Jessica G. Borger, Fabio Simbari, Elaine Robertson, Marissa Millar, Yvonne Harcus, Henry J. McSorley, Rick M. Maizels, Amy H. Buck

Publikováno v: Cell Reports, Vol 19, Iss 8, Pp 1545-1557 (2017)

Recent studies have demonstrated that many parasites release extracellular vesicles (EVs), yet little is known about the specific interactions of EVs with immune cells or their functions during infection. We show that EVs secreted by the gastrointest

Externí odkaz: https://doaj.org/article/8bb9b643cf804bdaa9b018beea56deb6

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Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity

Autor: Jessica G. Borger, Elaine Robertson, Jana McCaskill, Henry J. McSorley, Rick M. Maizels, Yvonne Harcus, Amy H. Buck, Fabio Simbari, Gillian Coakley, Marissa Millar

Publikováno v: Cell Reports, Vol 19, Iss 8, Pp 1545-1557 (2017)
Cell Reports
Coakley, G, McCaskill, J L, Borger, J G, Simbari, F, Robertson, E, Millar, M, Harcus, Y, McSorley, H J, Maizels, R M & Buck, A H 2017, ' Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity ', Cell Reports, vol. 19, no. 8, pp. 1545-1557 . https://doi.org/10.1016/j.celrep.2017.05.001

Summary Recent studies have demonstrated that many parasites release extracellular vesicles (EVs), yet little is known about the specific interactions of EVs with immune cells or their functions during infection. We show that EVs secreted by the gast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332e0ff9cd4b673d8c9b1217e624d7c0
https://eprints.gla.ac.uk/142915/1/142915.pdf

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