Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors

Autor: Christopher Sloas, Saar Gill, Michael Klichinsky

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Cellular immunotherapies represent a promising approach for the treatment of cancer. Engineered adoptive cell therapies redirect and augment a leukocyte’s inherent ability to mount an immune response by introducing novel anti-tumor capabilities and

Externí odkaz: https://doaj.org/article/00815eb322fe41ae977bcde18dd243c7

Unveiling and Characterizing Early Bilateral Interactions between Biofilm and the Mouse Innate Immune System

Autor: Christiane Forestier, Elisabeth Billard, Geneviève Milon, Pascale Gueirard

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

A very substantial progress has been made in our understanding of infectious diseases caused by invasive bacteria. Under their planktonic forms, bacteria transiently reside in the otherwise sterile mammal body tissues, as the physiological inflammati

Externí odkaz: https://doaj.org/article/b015445bbf3843088c978076a05a0f96

Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair

Autor: Sun-Kyeong Lee, Hector L. Aguila, Sanja Novak, Judith Kalinowski, Joseph A. Lorenzo, Ivo Kalajzic, Sandra Jastrzebski, Emilie Roeder

Publikováno v: The Journal of Immunology. 204:868-878

Osteoclasts (OC) originate from either bone marrow (BM)–resident or circulating myeloid OC progenitors (OCP) expressing the receptor CX3CR1. Multiple lines of evidence argue that OCP in homeostasis and inflammation differ. We investigated the relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02229db79af7e5ff7593b77ee1c215bf
https://doi.org/10.4049/jimmunol.1900665

Trained immunity in organ transplantation

Autor: Zahi A. Fayad, Jordi Ochando, Joren C. Madsen, Willem J. M. Mulder, Mihai G. Netea

Publikováno v: American Journal of Transplantation, 20, 10-18
American Journal of Transplantation, 20, 1, pp. 10-18
Repisalud
Instituto de Salud Carlos III (ISCIII)
American Journal of Transplantation

Consistent induction of donor‐specific unresponsiveness in the absence of continuous immunosuppressive therapy and toxic effects remains a difficult task in clinical organ transplantation. Transplant immunologists have developed numerous experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a569b966f31861295e8de85a8e2574fe
https://doi.org/10.1111/ajt.15620

SIRPα/CD47 axis controls the maintenance of transplant tolerance sustained by myeloid-derived suppressor cells

Autor: Bernard Vanhove, Bernard Martinet, Vanessa Gauttier, Sabrina Pengam, Virginie Thepenier, Véronique Daguin, Karine Renaudin, Nicolas Poirier, Justine Durand, Caroline Mary, Géraldine Teppaz, Claire Usal, Gilles Blancho, Nahzli Dilek

Publikováno v: American Journal of Transplantation
American Journal of Transplantation, Wiley, 2019, ⟨10.1111/ajt.15497⟩
American Journal of Transplantation, 2019, ⟨10.1111/ajt.15497⟩

International audience; Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature hematopoietic precursors known to suppress immune responses. Interaction of SIRP alpha (SIRPα), expressed by myeloid cells, with the ubiquitou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53905147eca8580b9b43888df2565bc1
https://doi.org/10.1111/ajt.15497