Zobrazeno 1 - 10
of 444
pro vyhledávání: '"macrodomain"'
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Chikungunya virus (CHIKV) hijacks host cell machinery to support its replication. Nucleophosmin 1 (NPM1/B23), a nucleolar phosphoprotein, is one of the host proteins known to restrict CHIKV infection; however, the mechanistic details of the
Externí odkaz:
https://doaj.org/article/261899ae7c6b4e3ba0932f11ee5ffbed
Akademický článek
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Publikováno v:
Viruses, Vol 15, Iss 12, p 2291 (2023)
Since the emergence of SARS-CoV-2, many genetic variations within its genome have been identified, but only a few mutations have been found in nonstructural proteins (NSPs). Among this class of viral proteins, NSP3 is a multidomain protein with 16 di
Externí odkaz:
https://doaj.org/article/de545eac3aa245edabc1e70da20f2fce
Publikováno v:
Pathogens, Vol 12, Iss 10, p 1221 (2023)
Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. Mac1 is an ADP-ribose bin
Externí odkaz:
https://doaj.org/article/6f5e6615ca144d4793a7b380b4af50a9
Autor:
Purwaniati Purwaniati, Asep Roni
Publikováno v:
Pharmaciana, Vol 12, Iss 1, Pp 1-12 (2022)
COVID-19 is still a global pandemic. The transmission is very fast and wide. Its prevalence continues to increase. There is no specific antiviral drug for SARS CoV 2 yet. This study aims to find lead compounds from compounds derived from spices that
Externí odkaz:
https://doaj.org/article/9380cd8be7e44afcb1705fb78194f378
Autor:
Andrea Hloušek-Kasun, Petra Mikolčević, Johannes Gregor Matthias Rack, Callum Tromans-Coia, Marion Schuller, Gytis Jankevicius, Marija Matković, Branimir Bertoša, Ivan Ahel, Andreja Mikoč
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4337-4350 (2022)
ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes. ADP-ribosylation targets proteins, nucleic acids, and small molecules (including
Externí odkaz:
https://doaj.org/article/1ef90c64e4a54320bbb532d01e369a8c
Akademický článek
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Publikováno v:
AMB Express, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract In the bio-based polymer industry, putrescine is in the spotlight for use as a material. We constructed strains of Escherichia coli to assess its putrescine production capabilities through the arginine decarboxylase pathway in batch fermenta
Externí odkaz:
https://doaj.org/article/c5079e024edc4531946c98ced0bc6e40
Akademický článek
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Autor:
Anwar Mohammad, Eman Alshawaf, Hossein Arefanian, Sulaiman K. Marafie, Abbas Khan, Dong-Qing Wei, Fahd Al-Mulla, Jehad Abubaker
Publikováno v:
Viruses, Vol 15, Iss 9, p 1907 (2023)
Among the different drug targets of SARS-CoV-2, a multi-domain protein known as NSP3 is a critical element of the translational and replication machinery. The macrodomain-I, in particular, has been reported to have an essential role in the viral atta
Externí odkaz:
https://doaj.org/article/76bf277a9c774a0f9038c395c6c41ba0