Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues

Autor: Francesca Nuti, Maud Larregola, Agnieszka Staśkiewicz, Bernhard Retzl, Nataša Tomašević, Lorenzo Macchia, Maria E. Street, Michał Jewgiński, Olivier Lequin, Rafal Latajka, Paolo Rovero, Christian W. Gruber, Michael Chorev, Anna Maria Papini

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT

Externí odkaz: https://doaj.org/article/5e89b8ca7f1645cab06fcfd921debf44

One-Pot Synthesis of Cycloparaphenylenes

Autor: Jan H. Griwatz, Hermann A. Wegner

Publikováno v: Organic Materials, Vol 02, Iss 04, Pp 306-312 (2020)

Abstract The preparation of cycloparaphenylenes ([n]CPPs) with their bent π-system poses a long-standing challenge in organic synthesis. In the current multi-step approaches to access CPPs, pre-angulated precursors were combined using transition met

Externí odkaz: https://doaj.org/article/d30854bc2d994f9eafb2524ca1aab8b3

An Efficient, Site-Selective and Spontaneous Peptide Macrocyclisation During in vitro Translation

Autor: Minglong Liu, Ryoji Yoshisada, Avand Amedi, Antonius J. P. Hopstaken, Mirte N. Pascha, Cornelis A. M. de Haan, Daan P. Geerke, David A. Poole, Seino A. K. Jongkees

Publikováno v: Liu, M, Yoshisada, R, Amedi, A, Hopstaken, A J P, Pascha, M N, de Haan, C A M, Geerke, D P, Poole, D A & Jongkees, S A K 2023, ' An Efficient, Site-Selective and Spontaneous Peptide Macrocyclisation During in vitro Translation ', Chemistry-A European Journal, vol. 29, no. 14, e202203923, pp. 1-9 . https://doi.org/10.1002/chem.202203923
Chemistry-A European Journal, 29(14):e202203923, 1-9. Wiley-VCH Verlag

Macrocyclisation provides a means of stabilising the conformation of peptides, often resulting in improved stability, selectivity, affinity, and cell permeability. In this work we report a new approach to peptide macrocyclisation using a cyanobenzoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906dac99d3a93a557f6fa16dc2ff109f
https://research.vu.nl/en/publications/1737dd4e-b9eb-4144-8ca7-6920dbf5f53f

Applications de la macrocyclisation par métathèse d'alcènes en flux continu et développement d'un réacteur facilitant la macrocyclisation photochimique

Autor: Morin, Émilie

Les réactions de macrocyclisation constituent un défi pour les chimistes de synthèse, car les sélectivités pour les réactions intramoléculaires par rapport à celles intermoléculaires sont difficiles à maximiser. Celles-ci sont donc effectu�

Externí odkaz: http://hdl.handle.net/1866/26806

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.