Zobrazeno 1 - 10
of 51
pro vyhledávání: '"mTORC1, mammalian target of rapamycin complex 1"'
Autor:
Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58c0ac6db641c550d04c5a5c6ba5a1a
https://doi.org/10.1016/j.apsb.2021.07.021
https://doi.org/10.1016/j.apsb.2021.07.021
Autor:
Kasper Hoebe, Shrinivas Bishu, John Y. Kao, Varsha Ganesan, Ankit Sharma, Yanfen Yang, Chang Zeng, Rodney D. Newberry, Sahiti Marella, Simon P. Hogan, Philip D. King, Ariel Munitz, Jazib Uddin, Taeko K. Noah, Lee A. Denson, Andrew R. Patterson, Simone Vanoni, Lisa Waggoner, Senad Divanovic, Paul S. Foster, Michael J. Rosen, S. M. S. Tomar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Background & Aims CD4+ T cells are regulated by activating and inhibitory cues, and dysregulation of these proper regulatory inputs predisposes these cells to aberrant inflammation and exacerbation of disease. We investigated the role of the inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bc9234d68120dd2171e099da6a99f4
http://europepmc.org/articles/PMC8531983
http://europepmc.org/articles/PMC8531983
Publikováno v:
Regenerative Therapy, Vol 17, Iss, Pp 8-12 (2021)
Regenerative Therapy
Regenerative Therapy
Recent studies have revealed that cancer stem cells (CSCs) undergo metabolic alterations that differentiate them from non-CSCs. Inhibition of specific metabolic pathways in CSCs has been conducted to eliminate the CSC population in many types of canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6e792e0488411d444bcff6479bbf43
https://doi.org/10.1016/j.reth.2021.01.005
https://doi.org/10.1016/j.reth.2021.01.005
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 569-581 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control of macromolecules and organelles. Since protein kinases are integral to the autophagy proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e45bf1ac401222740c4f8e78dae670
http://www.sciencedirect.com/science/article/pii/S221138351930276X
http://www.sciencedirect.com/science/article/pii/S221138351930276X
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 491-506 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in colorectal cancer (CRC) development, although they are implicated in the modulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7a306ac692719a8347e0c547725351
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
Autor:
Tram Anh Tran, Qing-Jun Zhang, Lei Wang, Christopher Gonzales, Luc Girard, Herman May, Thomas Gillette, Zhi-Ping Liu, Elisabeth D. Martinez
Publikováno v:
The Journal of Biological Chemistry
Hypertrophic/dilated cardiomyopathy, often a prequel to heart failure, is accompanied by maladaptive transcriptional changes that contribute to arrythmias and contractile misfunction. Transgenic mice constitutively expressing high levels of calcineur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112f854788555475bb177a80293d9bd2
https://pubmed.ncbi.nlm.nih.gov/34933013
https://pubmed.ncbi.nlm.nih.gov/34933013
Autor:
Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303
https://pubmed.ncbi.nlm.nih.gov/35024303
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 880-901 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 880-901 (2019)
The trend toward designing large hydrophobic molecules for lead optimization is often associated with poor drug-likeness and high attrition rates in drug discovery and development. Structural simplification is a powerful strategy for improving the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb376b89b70d546819c6896fcd6d927
https://doi.org/10.1016/j.apsb.2019.05.004
https://doi.org/10.1016/j.apsb.2019.05.004
Autor:
Hiroyuki Mano, Masahito Kawazu, Noboru Mizushima, Kaito Mimura, Jun-Ichi Sakamaki, Hideaki Morishita
Publikováno v:
The Journal of Biological Chemistry
Macroautophagy (hereafter, autophagy) is a process that directs the degradation of cytoplasmic material in lysosomes. In addition to its homeostatic roles, autophagy undergoes dynamic positive and negative regulation in response to multiple forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45dd2cb67d67cf999e1509428d95e52
http://europepmc.org/articles/PMC8191307
http://europepmc.org/articles/PMC8191307
Autor:
Xinyuan Liu, Rainer Heuchel, Jianping Liu, Anthony P. H. Wright, Gustav Arvidsson, Matthias Löhr, Beate Gündel, Xidan Li
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 7, Pp 101107-(2021)
Translational Oncology, Vol 14, Iss 7, Pp 101107-(2021)
Highlights • We described a straightforward and highly reproducible 3D culturing method to investigate the intercellular crosstalk between pancreatic cancer and pancreatic stellate cells (PSCs)/cancer associated fibroblasts (CAFs). • Pancreatic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309016806d03c6c70de0bb89b2ca621a
https://pubmed.ncbi.nlm.nih.gov/33946033
https://pubmed.ncbi.nlm.nih.gov/33946033