Zobrazeno 1 - 10
of 25
pro vyhledávání: '"mTORC1, mTOR complex 1"'
Autor:
Nicolas Bisson, Frédérick A. Mallette, Laurence M. Gagné, Marc-Étienne Huot, Jean-Philippe Lambert, Nadine Morin, Noémie Lavoie
Publikováno v:
The Journal of Biological Chemistry
Metabolic dysfunction is a major driver of tumorigenesis. The serine/threonine kinase mechanistic target of rapamycin (mTOR) constitutes a key central regulator of metabolic pathways promoting cancer cell proliferation and survival. mTOR activity is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f12996bbcdf1e104173be833b69be78
http://europepmc.org/articles/PMC8551655
http://europepmc.org/articles/PMC8551655
Autor:
Milana Fraiberg, Boris Macek, Zvulun Elazar, Philipp J. Kahle, Anna Lechado Terradas, Katharina Zittlau
Publikováno v:
The Journal of Biological Chemistry
The journal of biological chemistry 297(5), 101339 (2021). doi:10.1016/j.jbc.2021.101339
The journal of biological chemistry 297(5), 101339 (2021). doi:10.1016/j.jbc.2021.101339
Mitochondria are important organelles in eukaryotes. Turnover and quality control of mitochondria are regulated at the transcriptional and posttranslational level by several cellular mechanisms. Removal of defective mitochondrial proteins is mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbec8d603702bfc18179f4f97b4c81b
http://europepmc.org/articles/PMC8591368
http://europepmc.org/articles/PMC8591368
Autor:
Vo, Dat T., Karanam, Narasimha Kumar, Ding, Lianghao, Saha, Debabrata, Yordy, John S., Giri, Uma, Heymach, John V., Story, Michael D.
Publikováno v:
Neoplasia (New York, N.Y.)
MicroRNAs (miRNAs) are short single-stranded RNAs, measuring 21 to 23 nucleotides in length and regulate gene expression at the post-transcriptional level through mRNA destabilization or repressing protein synthesis. Dysregulation of miRNAs can lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65e42cbfcc3be79653e0b382f66f3a0f
http://europepmc.org/articles/PMC6642270
http://europepmc.org/articles/PMC6642270
Autor:
Richard I. Odle, Simon J. Cook
Publikováno v:
Autophagy
For the last two decades there has been wide ranging debate about the status of macroautophagy during mitosis. Because metazoan cells undergo an “open” mitosis in which the nuclear envelope breaks down, it has been proposed that macroautophagy mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f202150646847e3803597635630b582e
https://pubmed.ncbi.nlm.nih.gov/32079445
https://pubmed.ncbi.nlm.nih.gov/32079445
Autor:
Gregory R. Steinberg, Bassem Mekhaeil, Tobias Berg, Theodoros Tsakiridis, Lindsay A. Broadfield, Olga-Demetra Biziotis, Katarina Marcinko, Alexander E. Anagnostopoulos, Paola Muti, Amr Ali, Elham Ahmadi, Panayiotis G. Zacharidis, Aruz Mesci, Evangelia E. Tsakiridis, Kanwaldeep Singh
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 11, Pp 101209-(2021)
Translational Oncology, Vol 14, Iss 11, Pp 101209-(2021)
Highlights • Combined metformin + salicylate treatment has improved anti-tumor efficacy in prostate cancer. • At clinically achievable doses, it induces increased metabolic stress and sensitizes tumors to radiation. • Metformin + salicylate blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5df36c089042b2703592bddf8bc8750
https://doi.org/10.1016/j.tranon.2021.101209
https://doi.org/10.1016/j.tranon.2021.101209
Publikováno v:
The Journal of Biological Chemistry
The mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) signaling controls cell metabolism, promotes cell survival, and contributes to tumorigenesis, yet its upstream regulation remains poorly defined. Although considerable evidence supports th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fa35877d2e1f8ee7bc6c595ab10f92
https://doi.org/10.1016/j.jbc.2021.101100
https://doi.org/10.1016/j.jbc.2021.101100
Autor:
Sutiman Bambang Sumitro, Mohammad Aris Widodo, Kiptiyah Kiptiyah, Aulanni'am Aulanni'am, Gatot Ciptadi, Widodo Widodo
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 12, Iss 5, Pp 397-406 (2017)
Journal of Taibah University Medical Sciences
Journal of Taibah University Medical Sciences
Cumulus cells play a crucial role as essential mediators in the maturation of ova. Ginger contains 10-gingerol, which induces apoptosis in colon cancer cells. Based on this hypothesis, this study aimed to determine whether 10-gingerol is able to indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73471c1ea3864afe337bbdf878d1c0a8
http://www.sciencedirect.com/science/article/pii/S165836121730094X
http://www.sciencedirect.com/science/article/pii/S165836121730094X
Autor:
Shenglei Li, Yandan Ren, Fanghua Gong, Mengyin Zhang, Wen Zhao, Xiao-Jing Shi, Guiqin Hou, Zhaoming Lu, Yang Wang, Bin Yu, Jianying Zhang, Yan Li
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1004-1019 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 1004-1019 (2020)
Dysregulation of mTORC1/mTORC2 pathway is observed in many cancers and mTORC1 inhibitors have been used clinically in many tumor types; however, the mechanism of mTORC2 in tumorigenesis is still obscure. Here, we mainly explored the potential role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c1b59250e93bdc4a29506776673a67
https://pubmed.ncbi.nlm.nih.gov/32642408
https://pubmed.ncbi.nlm.nih.gov/32642408
Autor:
Yi Ren, Han-Ming Shen
Publikováno v:
Redox Biology
Redox Biology, Vol 25, Iss, Pp-(2019)
Redox Biology, Vol 25, Iss, Pp-(2019)
Glucose starvation is one of the major forms of metabolic stress in cancer cells. Deprivation of glucose impairs glycolysis and the pentose phosphate pathway, which elicits oxidative stress due to enhanced production of reactive oxygen species (ROS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed3374d5e3861a33fee3afc63c774d4
https://pubmed.ncbi.nlm.nih.gov/30853530
https://pubmed.ncbi.nlm.nih.gov/30853530
Autor:
Jessica Gasparello, Monica Borgatti, Roberto Gambari, Giulia Breveglieri, Enrica Fabbri, Nicoletta Bianchi, Alessia Finotti
Publikováno v:
Pharmacological Research
Graphical abstract
Rapamycin, an inhibitor of mTOR activity, is a potent inducer of erythroid differentiation and fetal hemoglobin production in β-thalassemic patients. Mithramycin (MTH) was studied to see if this inducer of K562 differentiatio
Rapamycin, an inhibitor of mTOR activity, is a potent inducer of erythroid differentiation and fetal hemoglobin production in β-thalassemic patients. Mithramycin (MTH) was studied to see if this inducer of K562 differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fcfc10bd4dd56e10a77d79271690d7
https://hdl.handle.net/11577/3478504
https://hdl.handle.net/11577/3478504
