A novel role of CRTC2 in promoting nonalcoholic fatty liver disease

Autor: Hee-Seok Kweon, Si-Hyong Jang, Kae Won Cho, Dahee Choi, Dae Ho Lee, Sang Gyune Kim, Tom Huh, Eunyong Ahn, Eunyoung Moon, Je Kyung Seong, Yongmin Kwon, Young Seok Kim, Seung Hoi Koo, Geum-Sook Hwang, Hye-Sook Han

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 55, Iss, Pp 101402-(2022)

Objective Diet-induced obesity is often associated with nonalcoholic fatty liver disease (NAFLD), which instigates severe metabolic disorders, including cirrhosis, hepatocellular carcinoma, and type 2 diabetes. We have shown that hepatic depletion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d6a1a13198cf55122cb3ee3531bcee
http://europepmc.org/articles/PMC8689247

Everolimus and intensive behavioral therapy in an adolescent with tuberous sclerosis complex and severe behavior

Autor: Mary Gregory, Michael V. Johnston, Lee E. Wachtel, Andrea Poretti, Heather K. Jennett, Tanjala T. Gipson

Publikováno v: Epilepsy & Behavior Case Reports

BackgroundSelf-injury and aggression have been reported in individuals with TSC (tuberous sclerosis complex), yet few data exist about treatment. Everolimus, an mTOR inhibitor, has been FDA-approved for subependymal giant cell astrocytomas (SEGAs) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc37df2f55ee62cf52f42070ef715d2
https://doi.org/10.1016/j.ebcr.2013.06.004

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Autor: Ruzica, Bago, Nazma, Malik, Michael J, Munson, Alan R, Prescott, Paul, Davies, Eeva, Sommer, Natalia, Shpiro, Richard, Ward, Darren, Cross, Ian G, Ganley, Dario R, Alessi

Publikováno v: Biochemical Journal

The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e482468dace2fe9575967a237a98adb3
https://pubmed.ncbi.nlm.nih.gov/25177796

Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection.

Autor: Barron L; Division of Pediatric Surgery, St. Louis Children's Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri., Sun RC; Division of Pediatric Surgery, St. Louis Children's Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri., Aladegbami B; Division of Pediatric Surgery, St. Louis Children's Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri., Erwin CR; Division of Pediatric Surgery, St. Louis Children's Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri., Warner BW; Division of Pediatric Surgery, St. Louis Children's Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri., Guo J; Division of Pediatric Surgery, St. Louis Children's Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2016 Dec 10; Vol. 3 (2), pp. 231-244. Date of Electronic Publication: 2016 Dec 10 (Print Publication: 2017).

Everolimus and intensive behavioral therapy in an adolescent with tuberous sclerosis complex and severe behavior.

Autor: Gipson TT; Tuberous Sclerosis Clinic, Kennedy Krieger Institute, Baltimore, MD, USA., Jennett H; Neurobehavioral Unit, Kennedy Krieger Institute, Baltimore, MD, USA., Wachtel L; Neurobehavioral Unit, Kennedy Krieger Institute, Baltimore, MD, USA., Gregory M; Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA., Poretti A; Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Johnston MV; Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA.

Publikováno v: Epilepsy & behavior case reports [Epilepsy Behav Case Rep] 2013 Aug 24; Vol. 1, pp. 122-5. Date of Electronic Publication: 2013 Aug 24 (Print Publication: 2013).