Zobrazeno 1 - 10
of 11
pro vyhledávání: '"mTORC, mTOR complex"'
Autor:
Andras Perl, Christian Geier
Publikováno v:
Autoimmunity Reviews
The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event during the adaptive immune response is the engagement of a T cell receptor by its cognate antigen presented by an anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3990d80b30d059d40d16ba75850ac283
https://pubmed.ncbi.nlm.nih.gov/34718162
https://pubmed.ncbi.nlm.nih.gov/34718162
Publikováno v:
The Journal of Allergy and Clinical Immunology
Impaired vaccine responses in older individuals are associated with alterations in both the quantity and quality of the T-cell compartment with age. As reviewed herein, the T-cell response to vaccination requires a fine balance between the generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1828b72cbaf9194ad52186ecab69e05f
https://pubmed.ncbi.nlm.nih.gov/32386655
https://pubmed.ncbi.nlm.nih.gov/32386655
Autor:
Martin Bidlingmaier, Birgit Rathkolb, Martin Hrabĕ de Angelis, Arne Hinrichs, Werner F. Blum, Sebastian Bultmann, Heinrich Leonhardt, Maik Dahlhoff, Simone Renner, Andreas Blutke, Eckhard Wolf, Barbara Kessler, Andreas Hoeflich, Hiroshi Nagashima, Maren Bernau, Mayuko Kurome, Rüdiger Wanke, Elisabeth Kemter, Armin M. Scholz
Publikováno v:
Molecular Metabolism, Vol 11, Iss, Pp 113-128 (2018)
Molecular Metabolism
Mol. Metab. 11, 113-128 (2018)
Molecular metabolism, 11: 113-128
Molecular Metabolism
Mol. Metab. 11, 113-128 (2018)
Molecular metabolism, 11: 113-128
Objective Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c4a72923ebcdfb6d5ba81facbff4eb
http://www.sciencedirect.com/science/article/pii/S2212877818302114
http://www.sciencedirect.com/science/article/pii/S2212877818302114
Autor:
Jiansong Ji, Ri Cui, Xiaoxi Fan, Peng Zou, Fazong Wu, Weiqian Chen, Xi Chen, Qianqian Zhang, Rajamanickam Vinothkumar, Guang Liang, Zhongwei Zhao
Publikováno v:
Redox Biol
Redox Biology, Vol 10, Iss C, Pp 78-89 (2016)
Redox Biology
Redox Biology, Vol 10, Iss C, Pp 78-89 (2016)
Redox Biology
Mechanistic/mammalian target of rapamycin (mTOR) has emerged as a new potential therapeutic target for gastric cancer. Rapamycin and rapamycin analogs are undergoing clinical trials and have produced clinical responses in a subgroup of cancer patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996fc2e0f8970a6c0fa2b5a280f19672
https://doi.org/10.1016/j.redox.2016.09.006
https://doi.org/10.1016/j.redox.2016.09.006
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Several members of the SLC9A family of Na+/H+ exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3d1e75bee61b94f9f40786eeffcbe07
https://pubmed.ncbi.nlm.nih.gov/28090568
https://pubmed.ncbi.nlm.nih.gov/28090568
Autor:
Julie Guillermet-Guibert, Alexander Gray, Bart Vanhaesebroeck, Inma M. Berenjeno, Stewart Fleming, Wayne Pearce
Publikováno v:
Biochemical Journal
The PI3K (phosphoinositide 3-kinase) pathway is commonly activated in cancer as a consequence of inactivation of the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10), a major negative regulator of PI3K signalling. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e5c2f41f43fae0efd40ae37e1b37e9
https://doi.org/10.1042/bj20111741
https://doi.org/10.1042/bj20111741
Autor:
Emmanouil Karteris, Yori Gidron, Anastasia G. Goumenou, Dionisis Mparmpakas, Elena Zachariades
Publikováno v:
Clinical Science (London, England : 1979)
The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ca9d02d143a4f397db1ff9de440d5f
http://europepmc.org/articles/PMC3379561
http://europepmc.org/articles/PMC3379561
Autor:
Dario R. Alessi, Jennifer Moran, Alexander Gray, Christine M. Chresta, Sabina Cosulich, Juan M. García-Martínez, Rosemary G. Clarke
Publikováno v:
Biochemical Journal
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein kinase C) family kinases such as Akt (protein kinase B), S6K (p70 ribosomal S6 kinase) and SGK (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2954c6be093252396b73728152492aed
https://doi.org/10.1042/bj20090489
https://doi.org/10.1042/bj20090489
Autor:
Boris N. Kholodenko, Natalia Volinsky, Cormac McCarthy, Nina Saban, Mariko Okada-Hatakeyama, Alex von Kriegsheim, Walter Kolch
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 35, Iss 2, p e00178 (2015)
Bioscience Reports, Vol 35, Iss 2, p e00178 (2015)
In MCF-7 breast cancer cells epidermal growth factor (EGF) induces cell proliferation, whereas heregulin (HRG)/neuregulin (NRG) induces irreversible phenotypic changes accompanied by lipid accumulation. Although these changes in breast cancer cells r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ef4589932267100ca4347d61ac0ead
https://doi.org/10.1042/bsr20140172
https://doi.org/10.1042/bsr20140172
Autor:
Bart Vanhaesebroeck, Larissa S. Moniz
Publikováno v:
Biochemical Journal
The majority of human cancers harbour mutations promoting activation of the Akt protein kinase, and Akt inhibitors are being evaluated in clinical trials. An important question concerns the understanding of the innate mechanisms that confer resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56af178bf350810955ab7ec16195ac68
https://doi.org/10.1042/bj20130617
https://doi.org/10.1042/bj20130617