Zobrazeno 1 - 10
of 278
pro vyhledávání: '"mTOR complex 1"'
Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism
Autor:
Simran Samra, Mehul Sharma, Maryam Vaseghi-Shanjani, Kate L. Del Bel, Loryn Byres, Susan Lin, Joshua Dalmann, Areesha Salman, Jill Mwenifumbo, Bhavi P. Modi, Catherine M. Biggs, Cyrus Boelman, Lorne A. Clarke, Anna Lehman, Stuart E. Turvey
Publikováno v:
HGG Advances, Vol 5, Iss 1, Pp 100259- (2024)
Summary: Microtubule affinity-regulating kinase 4 (MARK4) is a serine/threonine kinase that plays a key role in tau phosphorylation and regulation of the mammalian target of rapamycin (mTOR) pathway. Abnormal tau phosphorylation and dysregulation of
Externí odkaz:
https://doaj.org/article/bf3e9fa10478485a97952f4e524c5f92
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 9, Pp 2075-2081 (2023)
Recent studies have shown that a 9-hour fast in mice reduces the amount of time spent immobile in the forced swimming test. However, whether 9-hour fasting has therapeutic effects in female mice with depressive symptoms has not been established. Ther
Externí odkaz:
https://doaj.org/article/4836933aa26947b6b7d5d0cec8f6d216
Autor:
Huihui Chen, Zhiwen Liu, Jie Zha, Li Zeng, Runyan Tang, Chengyuan Tang, Juan Cai, Chongqing Tan, Hong Liu, Zheng Dong, Guochun Chen
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 8, Pp n/a-n/a (2023)
Abstract Objectives Conventional glucocorticoid (GC) treatment poses significant risks for opportunistic infections due to its suppressive impact on CD4+ T cells. This study aimed to explore the mechanisms by which GCs modulate the functionality of C
Externí odkaz:
https://doaj.org/article/d940a9981d13429f9ddeb0b225444b69
Autor:
Nakamura, Takeharu
甲第25181号
医博第5067号
新制||医||1071(附属図書館)
学位規則第4条第1項該当
Doctor of Agricultural Science
Kyoto University
DFAM
医博第5067号
新制||医||1071(附属図書館)
学位規則第4条第1項該当
Doctor of Agricultural Science
Kyoto University
DFAM
Externí odkaz:
http://hdl.handle.net/2433/288615
Akademický článek
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Akademický článek
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Autor:
Lijian Shao, Wuping Yang, Rui Xu, Shuqin Zhu, Yanqiu Huang, Huan Li, Xincheng Wu, Mengzhen Yue, Xiaoliang Xiong, Xiaowen Chen, Bohai Kuang, Guangqin Fan, Qingxian Zhu, Huihong Zeng
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2018)
Abstract Background Irradiation-induced kidney damage is inevitable during radiotherapeutic practice, which limits effective radiotherapy doses on tumor treatment. In the present study, the role of mTOR complex 1 (mTORC1) signaling was investigated i
Externí odkaz:
https://doaj.org/article/2c402ba91957409a983c4a542f047d97
Akademický článek
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Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Existing treatments against drug addiction are often ineffective due to the complexity of the networks of protein-drug and protein-protein interactions (PPIs) that mediate the development of drug addiction and related neurobiological disorders. There
Externí odkaz:
https://doaj.org/article/1fa569047d0649f9b061ad36efc0097f
Autor:
Kenneth Maiese
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 3, Pp 372-385 (2016)
Throughout the globe, diabetes mellitus (DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder. DM impacts multiple organs and affects all components of the cent
Externí odkaz:
https://doaj.org/article/0ebb77e959ac4059a10ccd5de769792d