Zobrazeno 1 - 10 of 121 pro vyhledávání: '"mTOR complex (mTORC)"'
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Akademický článek
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Akademický článek
A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies
Autor: Marni E. Harris-White, Kathie G. Ferbas, Ming F. Johnson, Pirooz Eslami, Aleksandra Poteshkina, Kalina Venkova, Alexandar Christov, Kenneth Hensley
Publikováno v: Neurobiology of Disease, Vol 84, Iss , Pp 60-68 (2015)
Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimin
Externí odkaz: https://doaj.org/article/53d44422aa2942b4a406d6bc8bb0da61
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3
TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast
Autor: Mihaela Angelova, Sebastian Eising, Florian Fröhlich, Simon Sprenger, David Teis, Christopher J. Stefan, Michael A. Widerin, Michael W. Hess, Yannick Weyer, Robbie Loewith, Verena Baumann, Oliver Schmidt
Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry
The endosomal sorting complexes required for transport (ESCRT) mediate evolutionarily conserved membrane remodeling processes. Here, we used budding yeast (Saccharomyces cerevisiae) to explore how the ESCRT machinery contributes to plasma membrane (P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d150ba802ec3fad8e5e9a8617206cd4
https://doi.org/10.1074/jbc.ra120.013222
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4
Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling
Autor: Amitabha Chattopadhyay, Neeraj Chauhan, Parijat Sarkar, Naseem A. Gaur, Dominique Sanglard, Alix T. Coste, Brooke D. Esquivel, Nitesh Kumar Khandelwal, Murielle Chauvel, Rajendra Prasad, Meghna Gupta, Paola Coccetti, Alok K. Mondal, Theodore C. White, Ashutosh Singh, Christophe d'Enfert
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (2), pp.412-432. ⟨10.1074/jbc.M117.807032⟩
Journal of Biological Chemistry, 2018, 293 (2), pp.412-432. ⟨10.1074/jbc.M117.807032⟩
Journal of Biological Chemistry 2 (293), 412-432. (2018)
International audience; ATP-binding cassette (ABC) transporters help export various substrates across the cell membrane and significantly contribute to drug resistance. However, a recent study reported an unusual case in which the loss of an ABC tran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580a4fd5ca2c807ff370de6a4f6e24b2
https://doi.org/10.1074/jbc.m117.807032
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Accumulation of autophagosomes confers cytotoxicity
Autor: C. Oliver Hanemann, Robert W. Button, Shouqing Luo, Sheridan L. Roberts, Thea L. Willis
Publikováno v: The Journal of Biological Chemistry
Autophagy comprises the processes of autophagosome synthesis and lysosomal degradation. In certain stress conditions, increased autophagosome synthesis may be associated with decreased lysosomal activity, which may result in reduced processing of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c56d6690be94c622655954b17f9918
http://europepmc.org/articles/PMC5566519
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Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol
Autor: Mathew P. Leese, Yu Chi Shen, Daysha Ferrer-Torres, Kate F. Barald, Wolfgang Dohle, Ravi Upadhyayula, Tammy Hsia, Barry V. L. Potter, Stephanie Cevallos, Ryan J. Messick, Douglas M. Jewett, Therese M. Roth
Publikováno v: British Journal of Cancer
Background: Both the number and size of tumours in NF1 patients increase in response to the rise in steroid hormones seen at puberty and during pregnancy. The size of tumours decreases after delivery, suggesting that hormone-targeting therapy might p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4288bf0d900ef0e86ae35fa044927f6
https://doi.org/10.1038/bjc.2015.345
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7
Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy*
Autor: Scott M. Ebert, Steven D. Kunkel, Christopher M. Adams, Steven A. Bullard, Michael C. Dyle, Daniel K. Fox, Jason M. Dierdorff, Daniel P. Cook, Kale S. Bongers
Publikováno v: The Journal of Biological Chemistry
Background: Skeletal muscle atrophy is a common and serious condition that lacks a pharmacologic therapy. Results: We used a systems-based strategy to identify tomatidine, a natural compound from tomato plants, as a novel small molecule inhibitor of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e2152d9a96b390d6bc53bb05de121d
http://europepmc.org/articles/PMC4031541
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p53/TAp63 and AKT Regulate Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling through Two Independent Parallel Pathways in the Presence of DNA Damage
Autor: Peter J. Houghton, Hakan Cam, Maren Cam, Hemant K. Bid, Linlin Xiao, Gerard P. Zambetti
Publikováno v: The Journal of Biological Chemistry
Background: mTORC1 integrates cellular inputs and is often deregulated in cancer. Results: In response to DNA damage, p53/TAp63 and AKT regulate mTORC1 through two independent parallel pathways. Conclusion: DNA damage activates Akt, resulting in inhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be7f2763dd907988fe8f290a2a32654
https://doi.org/10.1074/jbc.m113.530303
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Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging
Autor: Joseph Avruch, Noriko Oshiro, Joseph Rapley
Publikováno v: The Journal of Biological Chemistry
Background: Signaling by mTOR complex 1 requires its amino acid-stimulated binding to Rag GTPase heterodimers. Results: mTOR complex 1-Rag binding in vitro is independent of Rag guanyl nucleotide charging, and withdrawal of amino acids from cells doe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccc2d41573ed7d901f1eeb526231be2
https://doi.org/10.1074/jbc.m113.528505
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LKB1 acts as a critical gatekeeper of ovarian primordial follicle pool
Autor: Zong-Zhe Jiang, Xue-Shan Ma, Heide Schatten, Heng-Yu Fan, Qing-Yuan Sun, Zhen-Bo Wang, Meng-Wen Hu
Publikováno v: Oncotarget, vol 7, iss 5
Oncotarget
Liver Kinase b1 (LKB1/STK11)is a tumor suppressor responsible for the Peutz-Jeghers syndrome, an autosomal-dominant, cancer-prone disorder in which patients develop neoplasms in several organs, including the oviduct, ovary, and cervix. Besides, the C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ef83c1dc2ff7d7ef0c081538298961
https://escholarship.org/uc/item/1j76b13b
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