Zobrazeno 1 - 10
of 118
pro vyhledávání: '"mTOR, mechanistic target of rapamycin"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 322-339 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31e277e49b3a3364e9726d531259ad4
https://doi.org/10.1016/j.apsb.2020.09.001
https://doi.org/10.1016/j.apsb.2020.09.001
Autor:
Alexandre A. da Silva, Xuan Li, John E. Hall, Jussara M. do Carmo, Xuemei Dai, Romain Harmancey, F. N. Gava, Sydney P. Moak, Ana Carolina Mieko Omoto, Mateus C. Salgado, Sadia Ashraf
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Leptin protects against progression to heart failure after myocardial infarction. • This beneficial effect requires activation of the brain melanocortin system. • Stimulation of brain MC4R recapitulates the car
Highlights • Leptin protects against progression to heart failure after myocardial infarction. • This beneficial effect requires activation of the brain melanocortin system. • Stimulation of brain MC4R recapitulates the car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94f437f60a091ee6a6ead8385dccb7c
http://europepmc.org/articles/PMC7838051
http://europepmc.org/articles/PMC7838051
Autor:
Cristiano Rumio, Fabrizio Marcucci
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Tumor cells often switch from mitochondrial oxidative metabolism to glycolytic metabolism even under aerobic conditions. Tumor cell glycolysis is accompanied by several nonenzymatic activities among which induction of drug resistance has important th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa5b30ce2ee01dd517b432844e879a6
http://europepmc.org/articles/PMC7804361
http://europepmc.org/articles/PMC7804361
Autor:
Bruno Guedes, Baldi, Elzbieta, Radzikowska, Vincent, Cottin, Daniel F, Dilling, Ali, Ataya, Carlos Roberto Ribeiro, Carvalho, Sergio, Harari, Matthew, Koslow, Jan C, Grutters, Yoshikazu, Inoue, Nishant, Gupta, Simon R, Johnson
Publikováno v:
Chest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c55f307972bcb17e62cdac299d737bef
http://europepmc.org/articles/PMC8687712
http://europepmc.org/articles/PMC8687712
Autor:
Nicolas Bisson, Frédérick A. Mallette, Laurence M. Gagné, Marc-Étienne Huot, Jean-Philippe Lambert, Nadine Morin, Noémie Lavoie
Publikováno v:
The Journal of Biological Chemistry
Metabolic dysfunction is a major driver of tumorigenesis. The serine/threonine kinase mechanistic target of rapamycin (mTOR) constitutes a key central regulator of metabolic pathways promoting cancer cell proliferation and survival. mTOR activity is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f12996bbcdf1e104173be833b69be78
http://europepmc.org/articles/PMC8551655
http://europepmc.org/articles/PMC8551655
Autor:
Andras Perl, Christian Geier
Publikováno v:
Autoimmunity Reviews
The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event during the adaptive immune response is the engagement of a T cell receptor by its cognate antigen presented by an anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3990d80b30d059d40d16ba75850ac283
https://pubmed.ncbi.nlm.nih.gov/34718162
https://pubmed.ncbi.nlm.nih.gov/34718162
Autor:
Diane C. Fingar
Publikováno v:
The Journal of Biological Chemistry
Cellular growth and proliferation are primarily dictated by the mechanistic target of rapamycin complex 1 (mTORC1), which balances nutrient availability against the cell's anabolic needs. Central to the activity of mTORC1 is the RagA-RagC GTPase hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bef7bc1a7f5ff0510b70220fc1d5ae
http://europepmc.org/articles/PMC8416955
http://europepmc.org/articles/PMC8416955
Autor:
Nicole R. LeBoeuf, Victor Huang, Sameer Gupta, Robin Joyce, Ann S. LaCasce, Matthew S. Davids, Scott R. Granter, Anna K. Dewan, Saagar Jadeja, Daniel Q. Bach
Publikováno v:
JAAD Case Reports
JAAD case reports, vol 5, iss 5
JAAD case reports, vol 5, iss 5
Author(s): Dewan, Anna K; Gupta, Sameer; Bach, Daniel Q; Jadeja, Saagar; Granter, Scott; LaCasce, Ann; Joyce, Robin; Davids, Matthew S; Huang, Victor; LeBoeuf, Nicole R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a25e241a73d38e363c2b3434e105aa4
http://europepmc.org/articles/PMC6479163
http://europepmc.org/articles/PMC6479163
Publikováno v:
Aging Cell
Mitochondrial dysfunction has long been implicated to have a causative role in organismal aging. A mitochondrial molecule, nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 (NLRX1), represents the only NLR family member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfca677528be2e29f66f0f0b036611a
https://doi.org/10.1111/acel.13410
https://doi.org/10.1111/acel.13410
Autor:
Ebru S. Selen, Michael J. Wolfgang
Publikováno v:
The Journal of Biological Chemistry
The mechanistic target of rapamycin (mTOR) is often referred to as a master regulator of the cellular metabolism that can integrate the growth factor and nutrient signaling. Fasting suppresses hepatic mTORC1 activity via the activity of the tuberous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da26170e74a36a230b9f59cc4986fc2c
http://europepmc.org/articles/PMC8294577
http://europepmc.org/articles/PMC8294577