Zobrazeno 1 - 10
of 296
pro vyhledávání: '"mRNA therapeutics"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The messenger ribose nucleic acid (mRNA) in the form of Corona virus of 2019 (COVID-19) vaccines were effectively delivered through lipid nanoparticles (LNP) proving its use as effective carriers in clinical applications. In the present work
Externí odkaz:
https://doaj.org/article/d9cef7be40814275913de7d5973735a4
Autor:
Ruei-Min Lu, Hsiang-En Hsu, Ser John Lynon P. Perez, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Yin-Shiou Lin, Ching-Hang Liu, Shih-Han Ko, Christian Angelo P. Concio, Yi-Jen Su, Yi-Han Chang, Wen-Shan Li, Han-Chung Wu
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-36 (2024)
Abstract Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects. In this regard, lipid nanoparticles h
Externí odkaz:
https://doaj.org/article/0f6655b8145d4bda96e5f7a52141ca40
Autor:
Jixin Qu, Adithya Nair, George W. Muir, Kate A. Loveday, Zidi Yang, Ehsan Nourafkan, Emma N. Welbourne, Mabrouka Maamra, Mark J. Dickman, Zoltán Kis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102333- (2024)
Oligo-deoxythymidine (oligo-dT) ligand-based affinity chromatography is a robust method for purifying mRNA drug substances within the manufacturing process of mRNA-based products, including vaccines and therapeutics. However, the conventional batch m
Externí odkaz:
https://doaj.org/article/8be6ca0992cd4e1c8d99198ff00e1cbb
Autor:
Wei Li, Masha Huang, Zhaoping Wu, Yu Zhang, Ying Cai, Juncheng Su, Jia Xia, Fan Yang, Desheng Xiao, Wen Yang, Yingjie Xu, Zhaoqian Liu
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Triple‐negative breast cancer (TNBC) poses a challenging prognosis due to early metastasis driven by anoikis resistance. Identifying crucial regulators to overcome this resistance is vital for improving patient outcomes. In this study, a g
Externí odkaz:
https://doaj.org/article/502a57d8ae1844c1a2b427e2aff51170
Autor:
Vrunda Trivedi, Changlin Yang, Kelena Klippel, Oleg Yegorov, Christina von Roemeling, Lan Hoang-Minh, Graeme Fenton, Elizabeth Ogando-Rivas, Paul Castillo, Ginger Moore, Kaytora Long-James, Kyle Dyson, Bently Doonan, Catherine Flores, Duane A. Mitchell
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Despite advancements in the successful use of immunotherapy in treating a variety of solid tumors, applications in treating brain tumors have lagged considerably. This is due, at least in part, to the lack of well-characterized an
Externí odkaz:
https://doaj.org/article/dd7adebdc5ef44db8761e569a2065eb9
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract The development of in vitro transcribed mRNA (IVT mRNA)‐based therapeutics/vaccines depends on the management of IVT mRNA immunogenicity. IVT mRNA, which is used for intracellular protein translation, often triggers unwanted immune respons
Externí odkaz:
https://doaj.org/article/cab12ece8b704416b7ad6ea580f7fcd0
Autor:
Feng Zhou, Lujia Huang, Shiqin Li, Wenfang Yang, Fangmin Chen, Zhixiong Cai, Xiaolong Liu, Wujun Xu, Vesa‐Pekka Lehto, Ulrich Lächelt, Rongqin Huang, Yang Shi, Twan Lammers, Wei Tao, Zhi Ping Xu, Ernst Wagner, Zhiai Xu, Haijun Yu
Publikováno v:
Exploration, Vol 4, Iss 2, Pp n/a-n/a (2024)
Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in accordance with their superiority in expressing all sequence‐known proteins in vivo. In particular, with a small dosage of delivered mRNA, antigen‐presenting ce
Externí odkaz:
https://doaj.org/article/34b48205a3e34f03bd0a9eda1f1da5e0
Autor:
Yu-Shiuan Wang, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Joyce Pei-Yi Yuan, Jui-Ling Tsai, Han-Chung Wu
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-35 (2023)
Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating
Externí odkaz:
https://doaj.org/article/a726cbc007dd4215b7ef1c6581081d8a
Publikováno v:
Fundamental Research, Vol 3, Iss 5, Pp 749-759 (2023)
The idea of mRNA therapy had been conceived for decades before it came into reality during the Covid-19 pandemic. The mRNA vaccine emerges as a powerful and general tool against new viral infections, largely due to its versatility and rapid developme
Externí odkaz:
https://doaj.org/article/1021707fc12d4df396bd8accdbc15a9e
The potential of N2-modified cap analogues for precise genetic manipulation through mRNA engineering
Autor:
Karol Kurpiejewski, Anna Stankiewicz-Drogon, Karolina Piecyk, Eliza Rajkowska, Paulina Skrzypczyk, Jingping Geng, Edward Darzynkiewicz, Renata Grzela, Marzena Jankowska-Anyszka
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
The technology of mRNA-based drugs is currently being intensively developed and implemented. Medical products of this type are already being used as viral vaccines and could potentially find application in a wide range of diseases. The tremendous int
Externí odkaz:
https://doaj.org/article/98522c5c546a4021a4a4c25a75f139d2