Value of negatively correlated miR-205-5p/HMGB3 and miR-96-5p/FOXO1 on the diagnosis of breast cancer and benign breast diseases

Autor: Jiaying Li, Shuang Peng, Xuan Zou, Xiangnan Geng, Tongshan Wang, Wei Zhu, Tiansong Xia

Publikováno v: Cancer Pathogenesis and Therapy, Vol 1, Iss 3, Pp 159-167 (2023)

Background: MicroRNA (miRNA) and mRNA levels in matching specimens were used to identify miRNA–mRNA interactions. We aimed to integrate transcriptome, immunophenotype, methylation, mutation, and survival data analyses to examine the profiles of miR

Externí odkaz: https://doaj.org/article/32031281878244f39a4ca69263cfbb9e

CASowary: CRISPR-Cas13 guide RNA predictor for transcript depletion

Autor: Alexander Krohannon, Mansi Srivastava, Simone Rauch, Rajneesh Srivastava, Bryan C. Dickinson, Sarath Chandra Janga

Publikováno v: BMC Genomics, Vol 23, Iss 1, Pp 1-10 (2022)

Abstract Background Recent discovery of the gene editing system - CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) associated proteins (Cas), has resulted in its widespread use for improved understanding of a variety of biological

Externí odkaz: https://doaj.org/article/481167256dcb47cc85b673944de6d728

Immune Infiltration of CD8+ T Cells in Patients With Diabetic Pancreatic Cancer Reduces the Malignancy of Cancer Tissues: An In Silico Study

Autor: Zheng Ye, Delin Liu, Dechen Liu, Yinqi Lv, Yidi Zhang, Jun Zhang, Jiantong Bao, Xuelu Yuan, Jiaying Hou, Ling Li

Publikováno v: Frontiers in Endocrinology, Vol 12 (2022)

BackgroundAlthough the functional damage of the diabetic pancreas can affect the postoperative recovery of pancreatic cancer patients, there is no significant difference in the prognosis of pancreatic cancer patients with a history of diabetes and or

Externí odkaz: https://doaj.org/article/9ca0a3770da348c2af8019491b24df51

ADP-Ribosylation Post-Translational Modification: An Overview with a Focus on RNA Biology and New Pharmacological Perspectives

Autor: Giuseppe Manco, Giuseppina Lacerra, Elena Porzio, Giuliana Catara

Publikováno v: Biomolecules, Vol 12, Iss 3, p 443 (2022)

Cellular functions are regulated through the gene expression program by the transcription of new messenger RNAs (mRNAs), alternative RNA splicing, and protein synthesis. To this end, the post-translational modifications (PTMs) of proteins add another

Externí odkaz: https://doaj.org/article/46cd6c9c642847bab45bebb82e85da32

SeedTransNet: a directional translational network revealing regulatory patterns during seed maturation and germination

Autor: Bai, Bing, Schiffthaler, Bastian, van der Horst, Sjors, Willems, Leo, Vergara, Alexander, Karström, Jacob, Mähler, Niklas, Delhomme, Nicolas, Bentsink, Leónie, Hanson, Johannes, Molecular Plant Physiology, Sub Molecular Plant Physiology

Publikováno v: Journal of Experimental Botany, 74(7), 2416-2432
Journal of Experimental Botany 74 (2023) 7
Journal of Experimental Botany, 74(7). Oxford University Press

We describe the dramatic shifts in translation that occur during seed maturation, germination, and seedling establishment. Using network analysis, we identify putative regulatory relationships and subsequently confirm some of them in vivo.Seed matura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3471e386f11769bdc8116c05699e2cb
https://pub.epsilon.slu.se/30842/