Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA

Autor: Sonia Golombek, Thomas Hoffmann, Ludmilla Hann, Markus Mandler, Sabine Schmidhuber, Josefin Weber, Young-Tae Chang, Roman Mehling, Andrea Ladinig, Christian Knecht, Johanna Leyens, Christian Schlensak, Hans Peter Wendel, Achim Schneeberger, Meltem Avci-Adali

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 642-654 (2023)

Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimizatio

Externí odkaz: https://doaj.org/article/fb35e12ee64a40e1bef0ae30f9a604f7

ASL mRNA-LNP Therapeutic for the Treatment of Argininosuccinic Aciduria Enables Survival Benefit in a Mouse Model

Autor: Owen Daly, Azita Josefine Mahiny, Sara Majeski, Kevin McClintock, Julia Reichert, Gábor Boros, Gábor Tamás Szabó, Jonas Reinholz, Petra Schreiner, Steve Reid, Kieu Lam, Marlen Lepper, Melanie Adler, Tracy Meffen, James Heyes, Katalin Karikó, Pete Lutwyche, Irena Vlatkovic

Publikováno v: Biomedicines, Vol 11, Iss 6, p 1735 (2023)

Argininosuccinic aciduria (ASA) is a metabolic disorder caused by a deficiency in argininosuccinate lyase (ASL), which cleaves argininosuccinic acid to arginine and fumarate in the urea cycle. ASL deficiency (ASLD) leads to hepatocyte dysfunction, hy

Externí odkaz: https://doaj.org/article/25fe821524ea47a48910c484bef99572

ASL mRNA-LNP Therapeutic for the Treatment of Argininosuccinic Aciduria Enables Survival Benefit in a Mouse Model

Autor: Vlatkovic, Owen Daly, Azita Josefine Mahiny, Sara Majeski, Kevin McClintock, Julia Reichert, Gábor Boros, Gábor Tamás Szabó, Jonas Reinholz, Petra Schreiner, Steve Reid, Kieu Lam, Marlen Lepper, Melanie Adler, Tracy Meffen, James Heyes, Katalin Karikó, Pete Lutwyche, Irena

Publikováno v: Biomedicines; Volume 11; Issue 6; Pages: 1735

Argininosuccinic aciduria (ASA) is a metabolic disorder caused by a deficiency in argininosuccinate lyase (ASL), which cleaves argininosuccinic acid to arginine and fumarate in the urea cycle. ASL deficiency (ASLD) leads to hepatocyte dysfunction, hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::70340db4d8907d564b2348d655c7f221

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Fixed-Parameter Algorithms for Protein Similarity Search Under mRNA Structure Constraints

Autor: Guillaume Blin, Danny Hermelin, Guillaume Fertin, Stéphane Vialette

Publikováno v: Graph-Theoretic Concepts in Computer Science ISBN: 9783540310006
WG
Journal of Discrete Algorithms
Journal of Discrete Algorithms, Elsevier, 2008, 6 (4), pp.618-626
31st International Workshop on Graph-Theoretic Concepts in Computer Science (WG'05)
31st International Workshop on Graph-Theoretic Concepts in Computer Science (WG'05), Jun 2005, Metz, France, France. pp.271-282

International audience; In the context of protein engineering, we consider the problem of computing an mRNA sequence of maximal codon-wise similarity to a given mRNA (and consequently, to a given protein) that additionally satisfies some secondary s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5abc72f8be1017637cabf25a4dcb207
https://doi.org/10.1007/11604686_24