Zobrazeno 1 - 10
of 244
pro vyhledávání: '"mRNA isoforms"'
Autor:
Laura Schulz, Manuel Torres-Diz, Mariela Cortés-López, Katharina E. Hayer, Mukta Asnani, Sarah K. Tasian, Yoseph Barash, Elena Sotillo, Kathi Zarnack, Julian König, Andrei Thomas-Tikhonenko
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing events, including recently reported excision of a cryptic intron embedded within CD19
Externí odkaz:
https://doaj.org/article/7a025226aeea4eeeb954f32ea7752bb3
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing splicing pathways cannot be determined by traditional RNA-Seq,
Externí odkaz:
https://doaj.org/article/8b91d004d3a84adea8c40fb190b994de
Autor:
Ralph Patrick, David T. Humphreys, Vaibhao Janbandhu, Alicia Oshlack, Joshua W.K. Ho, Richard P. Harvey, Kitty K. Lo
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-27 (2020)
Abstract High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing overall expression levels, largely ignoring alternative mRNA isof
Externí odkaz:
https://doaj.org/article/b63da871092f462faa34bf435f39a886
Autor:
Antonia Assunto, Ursula Ferrara, Alessandro De Luca, Claudia Pivonello, Lisa Lombardo, Annapina Piscitelli, Cristina Tortora, Valentina Pinna, Paola Daniele, Rosario Pivonello, Maria Giovanna Russo, Giuseppe Limongelli, Annamaria Colao, Marco Tartaglia, Pietro Strisciuglio, Daniela Melis
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background Neurofibromatosis type 1 (NF1) is characterized by an extreme clinical variability both within and between families that cannot be explained solely by the nature of the pathogenic NF1 gene mutations. A proposed model hypothesizes
Externí odkaz:
https://doaj.org/article/5c639a6a498f4a9192924c7c0741b664
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-25 (2019)
Abstract Background Odorant receptor genes constitute the largest gene family in mammalian genomes and this family has been extensively studied in several species, but to date far less attention has been paid to the characterization of their mRNA 3
Externí odkaz:
https://doaj.org/article/cfb6ab47fc584a40a4d740285b602f54
Autor:
Natalia Kurowska, Barbara Strzalka-Mrozik, Marcel Madej, Klaudia Pająk, Celina Kruszniewska-Rajs, Wojciech Kaspera, Joanna Magdalena Gola
Publikováno v:
Cancers, Vol 14, Iss 8, p 1876 (2022)
Genes associated with the TGFβ isoforms are involved in a number of different cancers, and their effect on the progression of brain tumors is also being discussed. Using an oligonucleotide microarray method, we assessed differences in expression pat
Externí odkaz:
https://doaj.org/article/6456930721ed46cf947be4429637c609
Akademický článek
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Autor:
Hong Lou, Hongchuan Li, Kevin J. Ho, Luke L. Cai, Andy S. Huang, Tyler R. Shank, Michael R. Verneris, Michael L. Nickerson, Michael Dean, Stephen K. Anderson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Tet methylcytosine dioxygenase 2 (TET2) is a tumor suppressor gene that is inactivated in a wide range of hematological cancers. TET2 enzymatic activity converts 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC), an essential step in DNA d
Externí odkaz:
https://doaj.org/article/96b99fbd34af4bcb9e2300a3abdfafad
Autor:
Francesca R. Mariotti, Stefania Petrini, Tiziano Ingegnere, Nicola Tumino, Francesca Besi, Francesca Scordamaglia, Enrico Munari, Silvia Pesce, Emanuela Marcenaro, Alessandro Moretta, Paola Vacca, Lorenzo Moretta
Publikováno v:
OncoImmunology, Vol 8, Iss 3 (2019)
Under physiological conditions, PD-1/PD-L1 interactions regulate unwanted over-reactions of immune cells and contribute to maintain peripheral tolerance. However, in tumor microenvironment, this interaction may greatly compromise the immune-mediated
Externí odkaz:
https://doaj.org/article/f3bb7d8dde32471098b9e868b5b9c951
Autor:
Keiko Taniguchi-Ponciano, Eduardo Peña-Martínez, Gloria Silva-Román, Sandra Vela-Patiño, Ana Laura Guzman-Ortiz, Hector Quezada, Erick Gomez-Apo, Laura Chavez-Macias, Sophia Mercado-Medrez, Guadalupe Vargas-Ortega, Ana Laura Espinosa-de-los-Monteros, Baldomero Gonzales-Virla, Aldo Ferreira-Hermosillo, Etual Espinosa-Cardenas, Claudia Ramirez-Renteria, Ernesto Sosa, Blas Lopez-Felix, Gerardo Guinto, Daniel Marrero-Rodríguez, Moises Mercado
Publikováno v:
Genes, Vol 11, Iss 12, p 1422 (2020)
Background: Pituitary adenomas (PA) are the second most common tumor in the central nervous system and have low counts of mutated genes. Splicing occurs in 95% of the coding RNA. There is scarce information about the spliceosome and mRNA-isoforms in
Externí odkaz:
https://doaj.org/article/68662dd6a82c4886b815f382a53cadaa