Zobrazeno 1 - 10
of 239
pro vyhledávání: '"mRNA isoforms"'
Autor:
Laura Schulz, Manuel Torres-Diz, Mariela Cortés-López, Katharina E. Hayer, Mukta Asnani, Sarah K. Tasian, Yoseph Barash, Elena Sotillo, Kathi Zarnack, Julian König, Andrei Thomas-Tikhonenko
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing events, including recently reported excision of a cryptic intron embedded within CD19
Externí odkaz:
https://doaj.org/article/7a025226aeea4eeeb954f32ea7752bb3
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing splicing pathways cannot be determined by traditional RNA-Seq,
Externí odkaz:
https://doaj.org/article/8b91d004d3a84adea8c40fb190b994de
Autor:
Ralph Patrick, David T. Humphreys, Vaibhao Janbandhu, Alicia Oshlack, Joshua W.K. Ho, Richard P. Harvey, Kitty K. Lo
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-27 (2020)
Abstract High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing overall expression levels, largely ignoring alternative mRNA isof
Externí odkaz:
https://doaj.org/article/b63da871092f462faa34bf435f39a886
Autor:
Antonia Assunto, Ursula Ferrara, Alessandro De Luca, Claudia Pivonello, Lisa Lombardo, Annapina Piscitelli, Cristina Tortora, Valentina Pinna, Paola Daniele, Rosario Pivonello, Maria Giovanna Russo, Giuseppe Limongelli, Annamaria Colao, Marco Tartaglia, Pietro Strisciuglio, Daniela Melis
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Background Neurofibromatosis type 1 (NF1) is characterized by an extreme clinical variability both within and between families that cannot be explained solely by the nature of the pathogenic NF1 gene mutations. A proposed model hypothesizes
Externí odkaz:
https://doaj.org/article/5c639a6a498f4a9192924c7c0741b664
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-25 (2019)
Abstract Background Odorant receptor genes constitute the largest gene family in mammalian genomes and this family has been extensively studied in several species, but to date far less attention has been paid to the characterization of their mRNA 3
Externí odkaz:
https://doaj.org/article/cfb6ab47fc584a40a4d740285b602f54
Akademický článek
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Autor:
Hong Lou, Hongchuan Li, Kevin J. Ho, Luke L. Cai, Andy S. Huang, Tyler R. Shank, Michael R. Verneris, Michael L. Nickerson, Michael Dean, Stephen K. Anderson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Tet methylcytosine dioxygenase 2 (TET2) is a tumor suppressor gene that is inactivated in a wide range of hematological cancers. TET2 enzymatic activity converts 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC), an essential step in DNA d
Externí odkaz:
https://doaj.org/article/96b99fbd34af4bcb9e2300a3abdfafad
Autor:
Francesca R. Mariotti, Stefania Petrini, Tiziano Ingegnere, Nicola Tumino, Francesca Besi, Francesca Scordamaglia, Enrico Munari, Silvia Pesce, Emanuela Marcenaro, Alessandro Moretta, Paola Vacca, Lorenzo Moretta
Publikováno v:
OncoImmunology, Vol 8, Iss 3 (2019)
Under physiological conditions, PD-1/PD-L1 interactions regulate unwanted over-reactions of immune cells and contribute to maintain peripheral tolerance. However, in tumor microenvironment, this interaction may greatly compromise the immune-mediated
Externí odkaz:
https://doaj.org/article/f3bb7d8dde32471098b9e868b5b9c951
Autor:
Elena Pudova, Anastasiya Kobelyatskaya, Irina Katunina, Anastasiya Snezhkina, Kirill Nyushko, Maria Fedorova, Vladislav Pavlov, Elizaveta Bulavkina, Alexandra Dalina, Sergey Tkachev, Boris Alekseev, George Krasnov, Vsevolod Volodin, Anna Kudryavtseva
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12837
Castration-resistant prostate cancer (CRPC) is a common form of prostate cancer in which docetaxel-based chemotherapy is used as the first line. The present study is devoted to the analysis of transcriptome profiles of tumor cells in the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49840b8bc19e4c082f8867934ceb4654
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cells coordinate the rates of major biological processes in response to environmental conditions such as nutrient availability and temperature. Coordination mechanisms in which effects on one process are compensated for by effects on ano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61ef1259b62ddf7c7ae433171b3bbc2
http://europepmc.org/articles/PMC8794773
http://europepmc.org/articles/PMC8794773