Zobrazeno 1 - 10
of 2 135
pro vyhledávání: '"mRNA Translation"'
Autor:
Eric M. Cockman, Vivek Narayan, Belinda Willard, Sumangala P. Shetty, Paul R. Copeland, Donna M. Driscoll
Publikováno v:
RNA Biology, Vol 16, Iss 12, Pp 1682-1696 (2024)
Selenoproteins are a unique class of proteins that contain the 21st amino acid, selenocysteine (Sec). Addition of Sec into a protein is achieved by recoding of the UGA stop codon. All 25 mammalian selenoprotein mRNAs possess a 3′ UTR stem-loop stru
Externí odkaz:
https://doaj.org/article/13e62b08d7d8470e88c3a2f0917b072a
Autor:
Hailing Liu, Lei Xu, Shiwei Yue, Hongfei Su, Xing Chen, Qiumeng Liu, Hui Li, Huifang Liang, Xiaoping Chen, Jiefeng He, Zeyang Ding, Bixiang Zhang
Publikováno v:
Cancer Communications, Vol 44, Iss 9, Pp 1018-1041 (2024)
Abstract Background N4‐acetylcytidine (ac4C) represents a novel messenger RNA (mRNA) modification, and its associated acetyltransferase N‐acetyltransferase 10 (NAT10) plays a crucial role in the initiation and progression of tumors by regulating
Externí odkaz:
https://doaj.org/article/6514adfb45334e62b419b67a385c48fb
Autor:
Zi‐Qi Zheng, Cheng‐Rui Zhong, Cheng‐Zhi Wei, Xiao‐Jiang Chen, Guo‐Ming Chen, Run‐Cong Nie, Ze‐Wei Chen, Fei‐Yang Zhang, Yuan‐Fang Li, Zhi‐Wei Zhou, Yong‐Ming Chen, Ye‐Lin Liang
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Although messenger RNA translation is tightly regulated to preserve protein synthesis and cellular homeostasis, chronic exposure to interferon‐γ (IFN‐γ) in several cancers can lead to tryptophan (Trp) shortage via the indoleamine‐2,3
Externí odkaz:
https://doaj.org/article/7ddb0a1821684616baa3133b6da3303f
Autor:
Richard Taylor, Nikolas Nikolaou
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
In neurons, a diverse range of coding and non-coding RNAs localize to axons, dendrites, and synapses, where they facilitate rapid responses to local needs, such as axon and dendrite extension and branching, synapse formation, and synaptic plasticity.
Externí odkaz:
https://doaj.org/article/d5948f72a1ba40979afe12d98a401ae3
Autor:
Ziqi He, Chao Song, Sheng Li, Caitao Dong, Wenbiao Liao, Yunhe Xiong, Sixing Yang, Yuchen Liu
Publikováno v:
Advanced Science, Vol 11, Iss 17, Pp n/a-n/a (2024)
Abstract The CRISPR‐Cas system, initially for DNA‐level gene editing and transcription regulation, has expanded to RNA targeting with the Cas13d family, notably the RfxCas13d. This advancement allows for mRNA targeting with high specificity, part
Externí odkaz:
https://doaj.org/article/c502e566bd424c58af437f89860cd863
Autor:
Patrick B. F. O’Connor, Jennifer Mahony, Eoghan Casey, Pavel V. Baranov, Douwe van Sinderen, Martina M. Yordanova
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTBacteria have evolved diverse defense mechanisms to counter bacteriophage attacks. Genetic programs activated upon infection characterize phage–host molecular interactions and ultimately determine the outcome of the infection. In this study
Externí odkaz:
https://doaj.org/article/686b9e90ff334a5f9f68107dec1dc818
Autor:
Hyun-Bum Kim, Quentin Brosseau, Julia Radzio, Jinhui Wang, Hiromi Muramatsu, Da Kuang, M. Sean Grady, H. Isaac Chen, John A. Wolf, Alexandra V. Ulyanova, Tamas Bartfai, Junhyong Kim, Norbert Pardi, Jai-Yoon Sul, Paulo Arratia, James Eberwine
Publikováno v:
Frontiers in Drug Delivery, Vol 4 (2024)
Multi-RNA co-transfection is starting to be employed to stimulate immune responses to SARS-CoV-2 viral infection. While there are good reasons to utilize such an approach, there is little background on whether there are synergistic RNA-dependent cell
Externí odkaz:
https://doaj.org/article/cdc17219cd1044c0a5d55323f4af4300
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Human cytomegalovirus (HCMV) requires the robust expression of two immediate early proteins, IE1 and IE2, immediately upon infection to suppress the antiviral response and promote viral gene expression. While transcriptional control of IE1 a
Externí odkaz:
https://doaj.org/article/ccc81b91099b47a2a54e9e2ae7a19fed
Autor:
Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 198-213 (2023)
Abstract Background Chronic mTORC1 activation in skeletal muscle is linked with age‐associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal
Externí odkaz:
https://doaj.org/article/4d1f09455d51452bad1e1f064452da26
Autor:
Jikuan Jiang, Lusi Zhang, Jingling Zou, Jingyuan Liu, Jia Yang, Qian Jiang, Peiyun Duan, Bing Jiang
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 11, Pp 2526-2534 (2023)
Ras homolog enriched in brain (Rheb) is a small GTPase that activates mammalian target of rapamycin complex 1 (mTORC1). Previous studies have shown that constitutively active Rheb can enhance the regeneration of sensory axons after spinal cord injury
Externí odkaz:
https://doaj.org/article/607cb6eb70514b0ba36f43bbde43060c