Zobrazeno 1 - 10
of 376
pro vyhledávání: '"mRNA, messenger RNA"'
Autor:
Andreas Zollner, Nicole Przysiecki, Sophie Macheiner, Vera Reinstadler, Barbara Jelusic, Simon J. Reider, Herbert Tilg, Christina Watschinger, Alexandra Pfister, Herbert Oberacher, Alexander R. Moschen, Bernhard Texler
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 383-404 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Objective By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Although tofacitinib has demonstrated efficacy as the first-in-class JAKi in
Autor:
Zhuwen Wang, Derek J. Nancarrow, Jason R. Spence, D.K. Turgeon, Michael K. Dame, Daysha Ferrer-Torres, Max A. Hammer, Paramita Ray, David G. Beer, Patrick J. O’Brien, Theodore S. Lawrence, Tonaye Hinton, Joshua H. Wu, Angeline Wu, May San Martinho, Dipankar Ray
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 129-149 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims TP53 mutations underlie Barrett’s esophagus (BE) progression to dysplasia and cancer. During BE progression, the ubiquitin ligase (E3) RNF128/GRAIL switches expression from isoform 2 (Iso2) to Iso1, stabilizing mutant p53. However
Autor:
Heidi L. Weiss, Stephanie A. Rock, Tianyan Gao, Chi Wang, Jing Li, B. Mark Evers, Yuanyuan Wu, Kai Jiang, Yajuan Liu, Jianhang Jia
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 501-516 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 501-516 (2022)
Background & Aims: Intestinal stem cells (ISCs) are sensitive to dietary alterations and nutrient availability. Neurotensin (NT), a gut peptide localized predominantly to the small bowel and released by fat ingestion, stimulates the growth of intesti
Autor:
Chengjie Shan, Wenxin Jia, Minyi Qian, Lirui Wang, Bernd Schnabl, Dalei Wu, Nan Zhang, Yinan Zhang, Danyang Zhao, Meiling Zhang, Song Yang, Yufei Zhang, Yingsheng Gao, Quan Zhang, Chuyue Pan, Xu Shen, Jun Liu, Pengpeng Cai
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 233-256 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 233-256 (2022)
Background & Aims The ligand-activated transcription factor, aryl hydrocarbon receptor (AHR) can sense xenobiotics, dietary, microbial, and metabolic cues. Roles of Ahr in intestinal epithelial cells (IECs) have been much less elucidated compared wit
Autor:
Steven D. Townsend, Yaohua Yang, Jirong Long, Fang Yan, M. Kay Washington, Gang Zhao, Jessica Williams
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 441-457 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 441-457 (2022)
Background & Aims Intestinal mucositis, a severe complication of antineoplastic therapeutics, is characterized by mucosal injury and inflammation in the small intestine. Therapies for the prevention and treatment of this disease are needed. We invest
Autor:
Mansee Desai, Brittanya A. Limone, Betsy Furukawa, Lulu Wong, Melanie E. Tawfik, G. Alden Holmes, Justin Love
Publikováno v:
JAAD Case Reports, Vol 16, Iss, Pp 53-57 (2021)
JAAD Case Reports
JAAD Case Reports
Autor:
Beatrice Foglia, G. Villano, Ramy Younes, Emanuele Albano, Salvatore Sutti, Patrizia Pontisso, Riccardo Autelli, Ignazia Tusa, Naresh Naik Ramavath, Chiara Rosso, Elisabetta Rovida, Elisabetta Bugianesi, Erica Novo, Stefania Cannito, Maurizio Parola, Marina Maggiora, Claudia Bocca
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 459-482 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 459-482 (2022)
Background & Aims Hypoxia and hypoxia-inducible factors (HIFs) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation contributed significantly to nonalcoholic fatty liver disease progression in exp
Publikováno v:
The Journal of adolescent health : official publication of the Society for Adolescent Medicine, vol 70, iss 4
The Journal of Adolescent Health
The Journal of Adolescent Health
Autor:
Maurizio Federico
Publikováno v:
Cytokine & Growth Factor Reviews
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has given rise to the urgent need for vaccines and therapeutic interventions to address the spread of the SARS-CoV-2 virus. SARS-CoV-2 vaccines in development, and those being
Autor:
Kasper Hoebe, Shrinivas Bishu, John Y. Kao, Varsha Ganesan, Ankit Sharma, Yanfen Yang, Chang Zeng, Rodney D. Newberry, Sahiti Marella, Simon P. Hogan, Philip D. King, Ariel Munitz, Jazib Uddin, Taeko K. Noah, Lee A. Denson, Andrew R. Patterson, Simone Vanoni, Lisa Waggoner, Senad Divanovic, Paul S. Foster, Michael J. Rosen, S. M. S. Tomar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Background & Aims CD4+ T cells are regulated by activating and inhibitory cues, and dysregulation of these proper regulatory inputs predisposes these cells to aberrant inflammation and exacerbation of disease. We investigated the role of the inhibito