Zobrazeno 1 - 10
of 956
pro vyhledávání: '"mPGES-1"'
Autor:
Lauren M. Weaver, Madeline J. Stewart, Kai Ding, Charles D. Loftin, Fang Zheng, Chang-Guo Zhan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Abdominal aortic aneurysm (AAA) is a deadly, permanent ballooning of the aortic artery. Pharmacological and genetic studies have pointed to multiple proteins, including microsomal prostaglandin E2 synthase-1 (mPGES-1), as potentially promisi
Externí odkaz:
https://doaj.org/article/719d64beb3d04e969ef849bcfb2a61e3
Autor:
Ahlem Zaghmi, Erdem Aybay, Long Jiang, Mingmei Shang, Julia Steinmetz‐Späh, Fredrik Wermeling, Per Kogner, Marina Korotkova, Päivi Östling, Per‐Johan Jakobsson, Brinton Seashore‐Ludlow, Karin Larsson
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 317-335 (2024)
High‐throughput drug screening enables the discovery of new anticancer drugs. Although monolayer cell cultures are commonly used for screening, their limited complexity and translational efficiency require alternative models. Three‐dimensional ce
Externí odkaz:
https://doaj.org/article/4a29d39e06f844be8b5afb223e6cda70
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-11 (2023)
Abstract Status epilepticus (SE) in humans is characterized by prolonged convulsive seizures that are generalized and often difficult to control. The current antiseizure drugs (ASDs) aim to stop seizures quickly enough to prevent the SE-induced brain
Externí odkaz:
https://doaj.org/article/30bcdf7775e948848b293cd650680b4c
Akademický článek
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Publikováno v:
PeerJ, Vol 11, p e14936 (2023)
PGAM1 plays a critical role in cancer cell metabolism through glycolysis and different biosynthesis pathways to promote cancer. It is generally known as a crucial target for treating pancreatic ductal adenocarcinoma, the deadliest known malignancy wo
Externí odkaz:
https://doaj.org/article/c9ecda16ac5e4b3b8af5c2402c3d6d3d
Publikováno v:
Molecules, Vol 28, Iss 16, p 6059 (2023)
mPGES-1 is an enzyme, which, when activated by inflammatory factors, can cause prostaglandin E synthesis. Traditional non-steroidal anti-inflammatory drugs are capable of inhibiting prostaglandin production, yet they can also cause gastrointestinal r
Externí odkaz:
https://doaj.org/article/9a35b44b83ea4a0c8b5eaf3d7d8cfb21
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113966- (2022)
Neuroblastoma (NB) is the most common pediatric extracranial solid tumor arising from neural crest cells of the developing sympathetic nervous system. Despite marked advances in cancer treatment, the survival rate of high-risk NB remains unsatisfacto
Externí odkaz:
https://doaj.org/article/1f01f1f6d9804e36a061061b1e3fc937
Akademický článek
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Autor:
Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods, Dongmei Wu
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Background To examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, in experimental models of acute lung injury (ALI) and sepsis in transgenic mice constitutively expre
Externí odkaz:
https://doaj.org/article/35632fa1b861488a9bc88054c6b87659
Autor:
Ester Colarusso, Marianna Potenza, Gianluigi Lauro, Maria Giovanna Chini, Valentina Sepe, Angela Zampella, Katrin Fischer, Robert K. Hofstetter, Oliver Werz, Giuseppe Bifulco
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 5, Iss , Pp 100046- (2022)
Here we report the application of a multi-disciplinary protocol for investigating thiazolidin-4-one-based compounds as new promising anti-inflammatory agents interfering with the eicosanoid biosynthesis pathways. The workflow foresaw the generation o
Externí odkaz:
https://doaj.org/article/28d5a88b8f9f47c48c0a6c7656ee3ed4