Zobrazeno 1 - 10
of 149
pro vyhledávání: '"mHTT"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionHuntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT). Ras homolog enriched in the striatum (
Externí odkaz:
https://doaj.org/article/2fc59d55ef1e40448c87c4b1e4a63500
Autor:
Javier Ojalvo-Pacheco, Sokhna M. S. Yakhine-Diop, José M. Fuentes, Marta Paredes-Barquero, Mireia Niso-Santano
Publikováno v:
Biology, Vol 13, Iss 4, p 238 (2024)
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by an expansion of the CAG trinucleotide repeat in exon 1 of the huntingtin (HTT) gene. This expansion leads to a polyglutamine (polyQ) tract at the N-terminal end
Externí odkaz:
https://doaj.org/article/48af2c48b8b84bc3844ba079439145bf
Akademický článek
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Autor:
Jiahui Long, Xia Luo, Dongmei Fang, Haikun Song, Weibin Fang, Hao Shan, Peiqing Liu, Boxun Lu, Xiao-Ming Yin, Liang Hong, Min Li
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein encoded from extra tracts of CAG repeats in exon 1 of the HTT gene. mHTT proteins are neurotoxic to render the death of
Externí odkaz:
https://doaj.org/article/8f89bb3958d34310afa77354245e8cca
Autor:
Junsheng Yang, Chaoyue Zhang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
The autophagy-lysosomal pathway (ALP) is the major biological pathway responsible for clearing intracellular protein aggregates, therefore a promising target for treating diseases featuring the accumulation of aggregation-prone proteins, such as Hunt
Externí odkaz:
https://doaj.org/article/9bd076d04b9c4d0ab43b09bb0a71aa26
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 647-650 (2022)
Externí odkaz:
https://doaj.org/article/4961681881cb4cd7a64b97f7fc0d2c2b
Autor:
Kai-Po Chen, Kuo-Feng Hua, Fu-Ting Tsai, Ting-Yu Lin, Chih-Yuan Cheng, Ding-I. Yang, Hsien-Ta Hsu, Tz-Chuen Ju
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG repeats exceeds 36, the translated expanded polyglutamine-containing HTT pr
Externí odkaz:
https://doaj.org/article/f2d8f3d48b8b49b1a403ac4aecb9c14a
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 5, Pp 559-566 (2020)
Abstract Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansions in the huntingtin gene resulting in the synthesis of a misfolded form of the huntingtin protein (mHTT) which is toxic. The curren
Externí odkaz:
https://doaj.org/article/5be264da3eb3419cb74146ece0ab092d
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-9 (2019)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by a genetic abnormality in the huntingtin gene that leads to a polyglutamine repeat expansion of the huntingtin protein. The cleaved polyglutamine expansion of mutant huntin
Externí odkaz:
https://doaj.org/article/0d229b0c163b4f0f90242ef745e4b248
Autor:
Franziska Schindler, Nicole Praedel, Nancy Neuendorf, Severine Kunz, Sigrid Schnoegl, Michael A. Mason, Bridget A. Taxy, Gillian P. Bates, Ali Khoshnan, Josef Priller, Jan Grimm, Marcel Maier, Annett Boeddrich, Erich E. Wanker
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The deposition of mutant huntingtin (mHTT) protein aggregates in neurons of patients is a pathological hallmark of Huntington’s disease (HD). Previous investigations in cell-free and cell-based disease models showed mHTT exon-1 (mHTTex1) fragments
Externí odkaz:
https://doaj.org/article/39b7832b713b418b99c771d5d66fad70