Zobrazeno 1 - 10
of 1 738
pro vyhledávání: '"mGluR"'
Autor:
Jingqi He, Jinguang Li, Yisen Wei, Zhangyin He, Junyu Liu, Ning Yuan, Risheng Zhou, Xingtao He, Honghong Ren, Lin Gu, Yanhui Liao, Xiaogang Chen, Jinsong Tang
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Glutamatergic function abnormalities have been implicated in the etiology of treatment-resistant schizophrenia (TRS), and the efficacy of clozapine may be attributed to its impact on the glutamate system. Recently, evidence has em
Externí odkaz:
https://doaj.org/article/49563322fe4a4051a83dc7786efde292
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33050- (2024)
Pruritus is an uncomfortable sensation induced by various pruritogens, including serotonin. Serotonin, acting as an inflammatory mediator, can activate a histamine-independent pathway. Consequently, many anti-pruritus medications, such as antihistami
Externí odkaz:
https://doaj.org/article/598d898c0c514c099e6762879bb5be75
Autor:
Rosa Fernández, Karla Ramírez, Roberto Lorente-Bermúdez, Esther Gómez-Gil, Mireia Mora, Antonio Guillamon, Eduardo Pásaro
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionGender incongruence (GI) is characterized by a marked incongruence between an individual’s experienced/expressed gender and the assigned sex at birth. It includes strong displeasure about his or her sexual anatomy and secondary sex char
Externí odkaz:
https://doaj.org/article/846245694a8844f39a9d1fd164972431
Autor:
Karen J. Thompson, Sonia Watson, Chiara Zanato, Sergio Dall'Angelo, Joriene C. De Nooij, Bethany Pace‐Bonello, Fiona C. Shenton, Helen E. Sanger, Beverly A. Heinz, Lisa M. Broad, Noelle Grosjean, Jessica R. McQuillian, Marina Dubini, Susan Pyner, Iain Greig, Matteo Zanda, David Bleakman, Robert W. Banks, Guy S. Bewick
Publikováno v:
Experimental Physiology, Vol 109, Iss 1, Pp 81-99 (2024)
Abstract A metabotropic glutamate receptor coupled to phospholipase D (PLD‐mGluR) was discovered in the hippocampus over three decades ago. Its pharmacology and direct linkage to PLD activation are well established and indicate it is a highly atypi
Externí odkaz:
https://doaj.org/article/81a681306fa94df7a114941db1591a5b
Autor:
Balázs Sonkodi
Publikováno v:
Biophysica, Vol 3, Iss 4, Pp 695-710 (2023)
This opinion manuscript outlines how the hippocampal theta rhythm could receive two novel peripheral inputs. One of the ways this could be achieved is through Piezo2 channels and atypical hippocampal-like metabotropic glutamate receptors coupled to p
Externí odkaz:
https://doaj.org/article/4b52d356411d444da907808d741006cd
Autor:
Sébastien Delhaye, Marielle Jarjat, Asma Boulksibat, Clara Sanchez, Alessandra Tempio, Andrei Turtoi, Mauro Giorgi, Sandra Lacas-Gervais, Gabriele Baj, Carole Rovere, Viviana Trezza, Manuela Pellegrini, Thomas Maurin, Enzo Lalli, Barbara Bardoni
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106393- (2024)
Phosphodiesterase 2 A (PDE2A) is an enzyme involved in the homeostasis of cAMP and cGMP and is the most highly expressed PDE in human brain regions critical for socio-cognitive behavior. In cerebral cortex and hippocampus, PDE2A expression level is u
Externí odkaz:
https://doaj.org/article/c714b13b016449ffbe190912a5d2ec29
Publikováno v:
Brain Sciences, Vol 14, Iss 6, p 603 (2024)
High-frequency magnetic stimulation (HFMS) applied directly to the hippocampal slice preparation in vitro induces activity-dependent synaptic plasticity and metaplasticity. In addition, changes in synaptic transmission following HFMS involve the acti
Externí odkaz:
https://doaj.org/article/50cef6655de249608b80d41dcec44792
Autor:
Nadia Rabeh, Baraa Hajjar, Jude O. Maraka, Ashwin F. Sammanasunathan, Mohammed Khan, Saif M.I. Alkhaaldi, Samy Mansour, Rashed T. Almheiri, Hamdan Hamdan, Khaled S. Abd-Elrahman
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115733- (2023)
Glutamate, an excitatory neurotransmitter, is essential for neuronal function, and it acts on ionotropic or metabotropic glutamate receptors (mGluRs). A disturbance in glutamatergic signaling is a hallmark of many neurodegenerative diseases. Developi
Externí odkaz:
https://doaj.org/article/f134cbc200c249aa9dcd6bfd1686523f
Publikováno v:
Liver Research, Vol 7, Iss 1, Pp 1-8 (2023)
Alcohol-related liver disease (ALD) became an important health issue worldwide. Following chronic alcohol consumption, the development of ALD might be caused by metabolic and immunologic factors, such as reactive oxygen species (ROS) and pro-inflamma
Externí odkaz:
https://doaj.org/article/8ccf24c67fb840558ba8129febfaaf86
Autor:
Christopher J. E. Denning, Lauren E. Madory, Jessica N. Herbert, Ryan A. Cabrera, Karen K. Szumlinski
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1928 (2024)
Methamphetamine (MA) is a highly addictive drug, and MA use disorder is often comorbid with anxiety and cognitive impairment. These comorbid conditions are theorized to reflect glutamate-related neurotoxicity within the frontal cortical regions. Howe
Externí odkaz:
https://doaj.org/article/fffe02464e334e46a4a58fae725ee58c