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Akademický článek

Effect of intrahippocampal microinjection of VU0155041, a positive allosteric modulator of mGluR4, on long term potentiation in a valproic acid-induced autistic male rat model

Autor: Zahra Ebrahimi, Parsa Gholipour, Reihaneh Mohammadkhani, Reza Ghahremani, Abdolrahman Sarihi, Alireza Komaki, Iraj Salehi, Seyed Asaad Karimi

Publikováno v: IBRO Neuroscience Reports, Vol 16, Iss , Pp 629-634 (2024)

The precise cause of autism spectrum disorder (ASD) is not fully understood. Despite the involvement of glutamatergic dysregulation in autism, the specific contribution of mGlu4 receptors to synaptic plasticity remains unclear. Using the positive all

Externí odkaz: https://doaj.org/article/ee1200eddb6b46e0bb83a571cee34132

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Akademický článek

Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex

Autor: Simon Bossi, Hervé Daniel, Heather McLean

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (

Externí odkaz: https://doaj.org/article/3f53cd5df99c42419f2bb467a2aaa8ee

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Akademický článek

New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties

Autor: Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 211-225 (2022)

Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectiv

Externí odkaz: https://doaj.org/article/986c7044b75f497b83b535e2846fde7c

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Akademický článek

Dissociation of impulsive traits by subthalamic metabotropic glutamate receptor 4

Autor: Lukasz Piszczek, Andreea Constantinescu, Dominic Kargl, Jelena Lazovic, Anton Pekcec, Janet R Nicholson, Wulf Haubensak

Publikováno v: eLife, Vol 11 (2022)

Behavioral strategies require gating of premature responses to optimize outcomes. Several brain areas control impulsive actions, but the neuronal basis of natural variation in impulsivity between individuals remains largely unknown. Here, by combinin

Externí odkaz: https://doaj.org/article/6fd0b3a2a2f346bfa90ac9fa3a32584a

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