Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments

Autor: Akshita Gupta, Angelina Konnova, Mathias Smet, Matilda Berkell, Alessia Savoldi, Matteo Morra, Vincent Van averbeke, Fien H.R. De Winter, Denise Peserico, Elisa Danese, An Hotterbeekx, Elda Righi, mAb ORCHESTRA working group, Pasquale De Nardo, Evelina Tacconelli, Surbhi Malhotra-Kumar, Samir Kumar-Singh

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)

Background The role of host immunity in emergence of evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored.Methods In a prospective, observational, monocentric ORCHESTRA cohort study, conducted

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Clinical Impact of Monoclonal Antibodies in the Treatment of High-Risk Patients with SARS-CoV-2 Breakthrough Infections: The ORCHESTRA Prospective Cohort Study.

Autor: Savoldi A; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy., Morra M; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy., Castelli A; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy., Mirandola M; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy.; School of Health Sciences, University of Brighton, Brighton BN2 4AT, UK., Berkell M; Lab of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, 2610 Antwerp, Belgium.; Molecular Pathology Group, Cell Biology & Histology, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium., Smet M; Lab of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, 2610 Antwerp, Belgium., Konnova A; Molecular Pathology Group, Cell Biology & Histology, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium., Rossi E; CINECA-Interuniversity Consortium, Via Magnanelli 6/3, Casalecchio di Reno, 40033 Bologna, Italy., Cataudella S; CINECA-Interuniversity Consortium, Via Magnanelli 6/3, Casalecchio di Reno, 40033 Bologna, Italy., De Nardo P; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy., Gentilotti E; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy., Gupta A; Molecular Pathology Group, Cell Biology & Histology, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium., Fasan D; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy., Gibbin E; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy., Cioli Puviani F; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy., Hasenauer J; Helmholtz Center Munich-Germany Research Center for Environmental Heath, Institute for Computational Biology, 85764 Neuherberg, Germany.; Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany., Gusinow R; Helmholtz Center Munich-Germany Research Center for Environmental Heath, Institute for Computational Biology, 85764 Neuherberg, Germany.; Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany., Tami A; Department of Medical Microbiology & Infection Prevention, University Medical Center Groningen, 9713 AV Groningen, The Netherlands., Kumar-Singh S; Molecular Pathology Group, Cell Biology & Histology, Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium., Malhotra-Kumar S; Lab of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, 2610 Antwerp, Belgium., mAb Orchestra Working Group, Tacconelli E; Division of Infectious Diseases, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy.

Publikováno v: Biomedicines [Biomedicines] 2022 Aug 24; Vol. 10 (9). Date of Electronic Publication: 2022 Aug 24.