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pro vyhledávání: '"mAb, Monoclonal Antibody"'
Akademický článek
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Autor:
Bruce D. Wines, Halina M. Trist, Sandra Esparon, Rachael E. Impey, Graham A. Mackay, Robert K. Andrews, Tatiana P. Soares da Costa, Geoffrey A. Pietersz, Ross I. Baker, P. Mark Hogarth
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic activity of many monoclonal antibody therapies. Some monoclonal anti-FcγR antibodies activate their receptors, but the pro
Externí odkaz:
https://doaj.org/article/c9b14b59d6114647912e69dcf8f997d5
Autor:
Andy C. Tran, Gil R. Diogo, Matthew J. Paul, Alastair Copland, Peter Hart, Nickita Mehta, Edward. B. Irvine, Tufária Mussá, Pascal M. W. Drake, Juraj Ivanyi, Galit Alter, Rajko Reljic
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
New evidence has been emerging that antibodies can be protective in various experimental models of tuberculosis. Here, we report on protection against multidrug-resistant Mycobacterium tuberculosis (MDR-TB) infection using a combination of the human
Externí odkaz:
https://doaj.org/article/571ab20885874bdbbf5051fa15c6f248
Autor:
John B. Hagan, MD, Elizabeth Ender, MD, Rohit D. Divekar, MBBS, PhD, Thanai Pongdee, MD, Matthew A. Rank, MD
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 6, Iss 1, Pp 69-76 (2022)
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 6, Iss 1, Pp 69-76 (2022)
Objective: To estimate the potential risk for a future postmarket black box warning (BBW) of US Food and Drug Administration (FDA)-approved monoclonal antibodies (mAbs) because of the importance for medical clinicians to understand mAb risks and bene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401b96e5615755d7c31a16937dafc148
https://doi.org/10.1016/j.mayocpiqo.2021.11.009
https://doi.org/10.1016/j.mayocpiqo.2021.11.009
Autor:
Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)
Background & Aims: Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels. Tm6sf2-/- mice replicate the human phenotype but were n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c501eab0983bab28ced1482110d3291c
http://europepmc.org/articles/PMC8804273
http://europepmc.org/articles/PMC8804273
Autor:
Oliver Bluemel, Moritz Anuschek, Jakob W. Buecheler, Georg Hoelzl, Karoline Bechtold-Peters, Wolfgang Friess
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss, Pp 100108-(2022)
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X
Cryoconcentration upon large-scale freezing of monoclonal antibody (mAb) solutions leads to regions of different ratios of low molecular weight excipients, like buffer species or sugars, to protein. This study focused on the impact of the buffer spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1e879d7a95015ba4b711cb5c437c93
http://www.sciencedirect.com/science/article/pii/S2590156721000372
http://www.sciencedirect.com/science/article/pii/S2590156721000372
Autor:
Md Niaz Rahim, Min Wang, Tong Wang, Shihua He, Bryan D. Griffin, Darwyn Kobasa, Ruifu Yang, Zongmin Du, Xiangguo Qiu
Publikováno v:
Viruses, Vol 11, Iss 3, p 259 (2019)
Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication. To generate anti-filovirus monoclonal antibodies (mAbs) against the NP, mi
Externí odkaz:
https://doaj.org/article/8360f0dbfc0b4067819df6e4e0369f68
Autor:
Antonella D'Amore, Angela Acciarito, Antonino Moschella, Zeeshan Ali, Khouloud Boujnah, Saverio Alberti, Anna Laura Aloisi, Pasquale Simeone, Rossano Lattanzio, Paola Zanna, Giovanna Vacca, Marco Trerotola, Emanuela Guerra, Martina Ceci, Valeria Garbo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 415-428 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Trop-2 is a transmembrane signal transducer that can induce cancer growth. Using antibody targeting and N-terminal Edman degradation, we show here that Trop-2 undergoes cleavage in the first thyroglobulin domain loop of its extracellular region, betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6301cd7c391b29616c20ccc6f7b54ded
http://www.sciencedirect.com/science/article/pii/S1476558621000166
http://www.sciencedirect.com/science/article/pii/S1476558621000166
Autor:
Jie Zan, Bi Wang, Xuya Zhao, Xiya Deng, Hongda Ding, Zijing Wei, Shuai Wang, Zhi Huang, Minyi Lu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 465-487 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Hepatocellular carcinoma (HCC) is the most common type of hepatic malignancies, with poor prognosis and low survival rate. Paraspeckles, which are unique subnuclear structures, are recently found to be involved in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ab4ee8ec76c4cf013b60b95b4da027
http://www.sciencedirect.com/science/article/pii/S2352345X21000436
http://www.sciencedirect.com/science/article/pii/S2352345X21000436
Autor:
Cristiano Rumio, Fabrizio Marcucci
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)
Tumor cells often switch from mitochondrial oxidative metabolism to glycolytic metabolism even under aerobic conditions. Tumor cell glycolysis is accompanied by several nonenzymatic activities among which induction of drug resistance has important th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa5b30ce2ee01dd517b432844e879a6
http://europepmc.org/articles/PMC7804361
http://europepmc.org/articles/PMC7804361