Zobrazeno 1 - 10
of 2 135
pro vyhledávání: '"m6a modification"'
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract R-loops are three-stranded nucleic acid structures composed of an RNA–DNA hybrid and a displaced DNA strand. They are widespread and play crucial roles in regulating gene expression, DNA replication, and DNA and histone modifications. Howe
Externí odkaz:
https://doaj.org/article/c2882a76a5394450a938716e2e0b53bc
Autor:
Lili Zhang, Ziwei Chen, Gaoyuan Sun, Chang Li, Pengjie Wu, Wenrui Xu, Hui Zhu, Zaifeng Zhang, Yongbin Tang, Yayu Li, Yifei Li, Siyuan Xu, Hexin Li, Meng Chen, Fei Xiao, Yaqun Zhang, Wei Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Muscle-invasive bladder carcinoma (MIBC) is a serious and more advanced stage of bladder carcinoma. N6-Methyladenosine (m6A) is a dynamic and reversible modifications that primarily affects RNA stability and alternative splicing.
Externí odkaz:
https://doaj.org/article/cf97b269a0674bcd8d5cfd1e028326ed
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background The study aims to comprehensively combine colorectal cancer data cohorts in order to analyze the effects of various DNA methylation-coding genes on colorectal cancer patients. The annual incidence and mortality of colorectal cance
Externí odkaz:
https://doaj.org/article/5f32a20bd2594d1a9b236d9b96c48d2e
Publikováno v:
Neurospine, Vol 21, Iss 3, Pp 925-941 (2024)
Objective The study aimed to investigate the role of N6-methyladenosine (m6A) modification in spinal cord injury (SCI) and its underlying mechanism, focusing on the interplay between m6A methyltransferase-like 3 (METTL3), miR-30c, and autophagy-relat
Externí odkaz:
https://doaj.org/article/2e9b6b00672748dfa8e959dca557f587
Autor:
Cheng Wei, Dazhao Peng, Boyuan Jing, Bo Wang, Zesheng Li, Runze Yu, Shu Zhang, Jinquan Cai, Zhenyu Zhang, Jianning Zhang, Lei Han
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-27 (2024)
Abstract Background Circular RNAs (circRNAs) can influence a variety of biological functions and act as a significant role in the progression and recurrence of glioblastoma (GBM). However, few coding circRNAs have been discovered in cancer, and their
Externí odkaz:
https://doaj.org/article/6648633b644c40b4be0e3573545ac0fb
Autor:
Xiaofeng Cheng, Heng Yang, Yujun Chen, Zhenhao Zeng, Yifu Liu, Xiaochen Zhou, Cheng Zhang, An Xie, Gongxian Wang
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-24 (2024)
Abstract Background Circular RNAs (circRNAs) have been shown to be involved in tumorigenesis and progression. However, the role of circGLIS3 (hsa_circ_0002874) in prostate cancer (PCa) has yet not been reported. Methods Candidate circRNA were determi
Externí odkaz:
https://doaj.org/article/e51eecc61df34c858f6128334c9eccea
Publikováno v:
Cell Regeneration, Vol 13, Iss 1, Pp 1-15 (2024)
Abstract Intestinal epithelial cells (IECs) are pivotal for maintaining intestinal homeostasis through self-renewal, proliferation, differentiation, and regulated cell death. While apoptosis and necroptosis are recognized as distinct pathways, their
Externí odkaz:
https://doaj.org/article/e63cbb41294e4a50bfd44d742a16ece9
Autor:
Anqi Wang, Yuanyuan Zeng, Weijie Zhang, Jian Zhao, Lirong Gao, Jianjun Li, Jianjie Zhu, Zeyi Liu, Jian-an Huang
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-25 (2024)
Abstract Background The RNA N 6-methyladenosine (m6A) modification has become an essential hotspot in epigenetic modulation. Serine–arginine protein kinase 1 (SRPK1) is associated with the pathogenesis of various cancers. However, the m6A modificat
Externí odkaz:
https://doaj.org/article/af264806a2404290aefda0dd56591ca3
Autor:
Bang Xiao, Yiqing Zhu, Meng Liu, Meiting Chen, Chao Huang, Dabing Xu, Fang Wang, Shuhan Sun, Jinfeng Huang, Ningxia Sun, Fu Yang
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Background Ferroptosis is associated with the pathological progression of hemorrhagic injury and ischemia–reperfusion injury. According to our previous study, exosomes formed through bone marrow mesenchymal stem cells modified with miR-340
Externí odkaz:
https://doaj.org/article/9d8165f5b5d044618c641674f1a9d9a0
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Background N6-methyladenosine (m6A) regulates the progression of breast cancer (BC). We aimed to investigate the action and mechanism involved of methyltransferase-like protein 16 (METTL16) in BC growth and metastasis. Methods RT-qPCR, immun
Externí odkaz:
https://doaj.org/article/e7681fb2852643e5af57540bfdcd2c28