Zobrazeno 1 - 10
of 91
pro vyhledávání: '"m6a methylation modification"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Intervertebral disc degeneration (IVDD) is one of the most prevalent causes of chronic low back pain. The role of m6A methylation modification in disc degeneration (IVDD) remains unclear. We investigated immune-related m6A methylation regula
Externí odkaz:
https://doaj.org/article/c7d5948897db423a80e7bbf13011ebed
Silencing of FTO inhibits oxidative stress to relieve neuropathic pain by m6A modification of GPR177
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 7, Pp n/a-n/a (2024)
Abstract Background Neuropathic pain (NP) is a challenging health condition owing to its complex nature and associated multiple etiologies. The occurrence of NP involves the abnormal activity of neurons mediated by oxidative stress (OS). Previous res
Externí odkaz:
https://doaj.org/article/2cf2f37a3b5046c3ab3d594cbd1e554a
Publikováno v:
Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 10, Pp 1227-1235 (2023)
Objective·To detect the differences in m6A methylation modification and gene expression of liver tissue mRNA in high-fat diet-induced mouse models of non-alcoholic fatty liver disease (NAFLD) using microarray technology.Methods·The NAFLD models wer
Externí odkaz:
https://doaj.org/article/e04b8bcf00ed404d8cd312a91e4d6d73
Autor:
Yurong Huang, Qiuyun Xue, Jun Chang, Yuting Wang, Chenglong Cheng, Suowen Xu, Xiao Wang, Chenggui Miao
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation, antitumor, and antiviral immunity. However, the role of m6A modification in the pathogenesis
Externí odkaz:
https://doaj.org/article/f44ad434ad6d48e0b3c01456a0eae403
Autor:
Yongqing Li, Dantong Zhang, Yinan Gao, Peijun Wang, Zejun Wang, Bingyang Zhang, Junjun Liu, Diwen Ye, Wanshan Ma, Sumei Lu
Publikováno v:
Nutrition & Metabolism, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background Insulin resistance (IR) in hepatocytes endangers human health, and frequently results in the development of non-alcoholic fatty liver disease (NAFLD). Research on m6A methylation of RNA molecules has gained popularity in recent ye
Externí odkaz:
https://doaj.org/article/0995ef07135f493488048d0208a461eb
Exploration of m6A methylation regulators as epigenetic targets for immunotherapy in advanced sepsis
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background This study aims to deeply explore the relationship between m6A methylation modification and peripheral immune cells in patients with advanced sepsis and mine potential epigenetic therapeutic targets by analyzing the differential e
Externí odkaz:
https://doaj.org/article/069cac6c389b479bb7f237b7431f1660
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background It is well-established that most Hepatocellular carcinoma (HCC) patients die of metastasis, yet the potential mechanisms orchestrating metastasis remain poorly understood. Current evidence suggests that the dysregulation of METTL3
Externí odkaz:
https://doaj.org/article/aefe98282c934f0dadd7cfafed533309
Publikováno v:
Guoji Yanke Zazhi, Vol 23, Iss 5, Pp 723-730 (2023)
AIM: To investigate the role and mechanism of methyltransferase-like 3(METTL3)-mediated N6-methyladenosine(m6A)methylation modification in regulating biological activity of vascular endothelial cells in the pathogenesis of choroidal neovascularizatio
Externí odkaz:
https://doaj.org/article/9159a2a8e419458ea5fa2221b7ac5284
Autor:
Tianyu Jiang, Yao Xiao, Jinfeng Zhou, Zupeng Luo, Lin Yu, Qichao Liao, Siqi Liu, Xinyi Qi, Hao Zhang, Menglong Hou, WeiWei Miao, Batbold Batsaikhan, Turtushikh Damba, Yunxiao Liang, Yixing Li, Lei Zhou
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102963- (2023)
Non-alcoholic fatty liver disease (NAFLD) is a potentially serious disease that affects 30 % of the global population and poses a significant risk to human health. However, to date, no safe, effective and appropriate treatment modalities are availabl
Externí odkaz:
https://doaj.org/article/6136eaf519a1484bba41754c6a502a80
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