Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene

Autor: Lucie Poppova, Sarka Pavlova, Beatriz Gonzalez, Jana Kotaskova, Karla Plevova, Gabrijela Dumbovic, Pavlina Janovska, Vojtech Bystry, Anna Panovska, Lucie Bezdekova, Stanislava Maslejova, Yvona Brychtova, Michael Doubek, Marcela Krzyzankova, Marek Borsky, Jiri Mayer, Vitezslav Bryja, Sergio Alonso, Sarka Pospisilova

Publikováno v: Epigenetics, Vol 17, Iss 12, Pp 1628-1635 (2022)

Genome methylation profiles define naïve-like (n-CLL), memory-like (m-CLL), and intermediate (i-CLL) subsets of chronic lymphocytic leukaemia (CLL). The profiles can be easily determined by the analysis of the five-CpG signature. m-CLL, i-CLL, and n

Externí odkaz: https://doaj.org/article/2ac6200ffdb247bbae9278ab0e3327a5

Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene

Autor: Poppova, L, Pavlova, S, Gonzalez, B, Kotaskova, J, Plevova, K, Dumbovic, G, Janovska, P, Bystry, V, Panovska, A, Bezdekova, L, Maslejova, S, Brychtova, Y, Doubek, M, Krzyzankova, M, Borsky, M, Mayer, J, Bryja, V, Alonso, S, Pospisilova, S

Publikováno v: Epigenetics
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Genome methylation profiles define naive-like (n-CLL), memory-like (m-CLL), and intermediate (i-CLL) subsets of chronic lymphocytic leukaemia (CLL). The profiles can be easily determined by the analysis of the five-CpG signature. m-CLL, i-CLL, and n-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::0c4bfe3f9fe2b625a418988c8faf5867
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2532

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Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene.

Autor: Poppova L; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Pavlova S; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Gonzalez B; IGTP-PMPPC: Program of Predictive and Personalized Medicine of Cancer, Germans Trias I Pujol Research Institute, Badalona, Spain., Kotaskova J; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Plevova K; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.; Institute of Medical Genetics and Genomics, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Dumbovic G; IGTP-PMPPC: Program of Predictive and Personalized Medicine of Cancer, Germans Trias I Pujol Research Institute, Badalona, Spain.; Institute for Cardiovascular Regeneration, Center for Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany., Janovska P; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Bystry V; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Panovska A; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Bezdekova L; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Maslejova S; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Brychtova Y; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Doubek M; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.; Institute of Medical Genetics and Genomics, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Krzyzankova M; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Borsky M; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Mayer J; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Bryja V; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Alonso S; IGTP-PMPPC: Program of Predictive and Personalized Medicine of Cancer, Germans Trias I Pujol Research Institute, Badalona, Spain., Pospisilova S; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.; Institute of Medical Genetics and Genomics, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Publikováno v: Epigenetics [Epigenetics] 2022 Dec; Vol. 17 (12), pp. 1628-1635. Date of Electronic Publication: 2022 Mar 25.