Zobrazeno 1 - 10
of 264
pro vyhledávání: '"m-Tor"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Objective: The PRAS40 is an essential inhibitory subunit of the mTORC1 complex, which regulates autophagy. It has been suggested that Erxian Decoction (EXD) could treat spinal cord injury (SCI) via the autophagy pathway. However, the mechanism of whe
Externí odkaz:
https://doaj.org/article/67e1f1499d1b4d779f2271ba9e0d7fb5
Publikováno v:
BMC Pharmacology and Toxicology, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Osteonecrosis of the jaw (ONJ) is a rare but serious adverse drug reaction (ADR) commonly associated with bisphosphonate and denosumab therapy. Prior research utilized an online, public FDA Adverse Event Reporting System (FAERS) D
Externí odkaz:
https://doaj.org/article/8fee2df0444140328277004a92472fd1
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 2, Pp 225-232 (2023)
Objective To study the mechanism of learning and memory impairment in aged female mice caused by chronic stress. Methods Twenty-month-old ICR mice were randomly divided into four groups: control females, control males, stressed females, and stressed
Externí odkaz:
https://doaj.org/article/92d17f4adce240f2aa73534fb1de338c
Autor:
Minguez Ojeda César, Lorca Álvaro Javier, López-Rodríguez Mónica A., Andreu Arnanz Ana, Tagalos Muñoz Ana Cristina, Gómez Dos Santos Victoria, Burgos Revilla Francisco Javier
Publikováno v:
Medicina Clínica Práctica, Vol 6, Iss 4, Pp 100372- (2023)
Perivascular epithelioid cell tumors (PEComa) are rare neoplasms defined as mesenchymal tumors with distinctive histology and immunohistochemistry. They tend to occur in middle-aged patients and mostly in women. The tumours cells show an association
Externí odkaz:
https://doaj.org/article/7b602456be5b448d94a1764448b421cc
Autor:
Fei Chen, Wen-min Yi, Sheng-yuan Wang, Ming-hao Yuan, Jie Wen, Hong-Yan Li, Qian Zou, Shu Liu, Zhi-you Cai
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
High-fat diets (HFDs) are related to the incidence of obesity and diabetes, but the effect of high-fat diet-induced brain damage remains to be clarified. In our study, we found that 24 weeks of a HFD effectively induced obesity and a change in fur co
Externí odkaz:
https://doaj.org/article/84f13653a6414a62bd74280bdf3db477
Autor:
Bingqian Zhang, Zhenhua Zhao, Ya’nan Huang, Haijia Mao, Mingyue Zou, Cheng Wang, Guangmao Yu, Minming Zhang
Publikováno v:
BMC Medical Imaging, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background To explore if the quantitative perfusion histogram parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the expression of PTEN, P-Akt and m-TOR protein in lung cancer. Methods Thirty‐three
Externí odkaz:
https://doaj.org/article/45d14ef15fd244b68272ac52b8f7dad8
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
ObjectiveTo investigate the protective effects of crocetin against transforming growth factor-β (TGF-β)—induced injury in LO2 cells.MethodsHuman hepatocyte LO2 cells were pre-treated with crocetin (10 μM) for 6, 12, and 24 h, and then induced by
Externí odkaz:
https://doaj.org/article/2ca8865bace3428a867a774f3df5812d
Autor:
Zhihui Liu, Jiacai Yang, Yunxia Chen, Cheng Chen, Jue Wang, Yew Mun Lee, Wenxia Zheng, Ruoyu Shang, Yuanyang Tang, Xiaorong Zhang, Xiaohong Hu, Yong Huang, Shiya Peng, Yih-Cherng Liou, Weifeng He, Gaoxing Luo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
As a potential clinical therapeutic cell for injured tissue repair, mesenchymal stem cells (MSCs) have attracted increasing attention. Enhancing the pro-healing function of MSCs has gradually become an essential topic in improving the clinical effica
Externí odkaz:
https://doaj.org/article/7c805fc704ad4ff684d9f4f8a46a9601
Autor:
Farzaneh Ashrafi, Shahrzad Shahidi, Valiollah Mehrzad, Mojgan Mortazavi, Sayyiedh Forough Hosseini
Publikováno v:
International Journal of Hematology-Oncology and Stem Cell Research, Vol 15, Iss 4 (2021)
Background: One of the important causes of mortality and morbidity in kidney transplanted patients is Post Transplant Lymphoproliferative Disease (PTLD), which is due to immunosuppression therapy and viral activity. It seems that Rapamycin, with dual
Externí odkaz:
https://doaj.org/article/08960da25887402ebc8dd6ed3f1188c6
Autor:
Nada El-Megiri, Yasser M. Mostafa, Amal Ahmed, Eman T. Mehanna, Mona F. El-Azab, Fatma Alshehri, Hadil Alahdal, Norhan M. El-Sayed
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1113 (2022)
Disturbance of glucose metabolism, nerve growth factor (NGF) and m-TOR signaling have been associated with the pathophysiology of epilepsy. Pioglitazone (PGZ) is an anti-diabetic drug that shows a protective effect in neurodegenerative diseases inclu
Externí odkaz:
https://doaj.org/article/1670270e883a45dabb9becc7a7503a2e