Zobrazeno 1 - 10
of 347
pro vyhledávání: '"lysosomal system"'
Autor:
Mengqi Hao, Jianjian Chu, Tinglin Zhang, Tong Yin, Yuankai Gu, Wendanqi Liang, Wenbo Ji, Jianhua Zhuang, Yan Liu, Jie Gao, You Yin
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 2, Pp 424-439 (2025)
Alzheimer’s disease is a debilitating, progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins, including amyloid plaques and intracellular tau tangles, primarily within the brain. Lysosomes, crucia
Externí odkaz:
https://doaj.org/article/ac085bdba31440ecb8718abac96efc38
Autor:
Kamil Adamiak, Marta Sidoryk-Węgrzynowicz, Beata Dąbrowska-Bouta, Grzegorz Sulkowski, Lidia Strużyńska
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 286, Iss , Pp 117180- (2024)
The extensive production and use of plastics in recent decades has led to environmental pollution. It has been discovered that plastic microparticles (MPs) and nanoparticles (NPs), formed under the influence of physical forces, can pose a significant
Externí odkaz:
https://doaj.org/article/07e0679c66454e54a9b83c38eb4989ac
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Background Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage dis
Externí odkaz:
https://doaj.org/article/4ea2394ac7fa4eb59e18243bad63c6a7
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging
Externí odkaz:
https://doaj.org/article/e251097c1af04747ba3adb6ef56ad682
Autor:
Liza Bergkvist, Zhen Du, Greta Elovsson, Hanna Appelqvist, Laura S. Itzhaki, Janet R. Kumita, Katarina Kågedal, Ann‐Christin Brorsson
Publikováno v:
FEBS Open Bio, Vol 10, Iss 3, Pp 338-350 (2020)
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people and currently lacking available disease‐modifying treatments. Appropriate disease models are necessary to investigate disease mechanisms and potential treatm
Externí odkaz:
https://doaj.org/article/d3371f795ac8455391516ee6c99ced82
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-13 (2019)
Abstract Background Brain endothelial cell-based in vitro models are among the most versatile tools in blood–brain barrier research for testing drug penetration to the central nervous system. Transcytosis of large pharmaceuticals across the brain c
Externí odkaz:
https://doaj.org/article/a1ffaf25f16c48398ddf963620e6cdf0
Autor:
Dawit A. Gonçalves, Wilian A. Silveira, Leandro H. Manfredi, Flávia A. Graça, Andrea Armani, Enrico Bertaggia, Brian T. O´Neill, Natalia Lautherbach, Juliano Machado, Leonardo Nogara, Marcelo G. Pereira, Diletta Arcidiacono, Stefano Realdon, C. Ronald Kahn, Marco Sandri, Isis C. Kettelhut, Luiz Carlos C. Navegantes
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 455-475 (2019)
Abstract Background Stimulation of β2‐adrenoceptors can promote muscle hypertrophy and fibre type shift, and it can counteract atrophy and weakness. The underlying mechanisms remain elusive. Methods Fed wild type (WT), 2‐day fasted WT, muscle‐
Externí odkaz:
https://doaj.org/article/f341a8776db04f97b5771d9cee49e3e4
Autor:
Kahina Mehennaoui, Sébastien Cambier, Laëtitia Minguez, Tommaso Serchi, François Guérold, Arno C. Gutleb, Laure Giamberini
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 210, Iss , Pp 111775- (2021)
The aim of the present study was the assessment of the sub-chronic effects of silver (AgNPs) and gold nanoparticles (AuNPs) of 40 nm primary size either stabilised with citrate (CIT) or coated with polyethylene glycol (PEG) on the freshwater inverteb
Externí odkaz:
https://doaj.org/article/2b5e479155a84772a3f8fabe3273bc72