Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

Autor: Lorena Fernandez-Mosquera, Massimiliano Stagi, Ira Milosevic, Cátia V. Diogo, King Faisal Yambire, Nuno Raimundo, Amy H. Ponsford, Leonardo Pereyra, Kamil Pabis, Renata Couto

Publikováno v: Autophagy

Mitochondria are key organelles for cellular metabolism, and regulate several processes including cell death and macroautophagy/autophagy. Here, we show that mitochondrial respiratory chain (RC) deficiency deactivates AMP-activated protein kinase (AM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9ff75f4f1edf2a4e27a55327a255ca
http://europepmc.org/articles/PMC6693470

Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.

Autor: Bretou M; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Sannerud R; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Escamilla-Ayala A; VIB-BioImaging Core, VIB-Center for Brain and Disease Research, Leuven, Belgium., Leroy T; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Vrancx C; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Van Acker ZP; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Perdok A; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Vermeire W; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Vorsters I; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Van Keymolen S; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium., Maxson M; Cell Biology Program, The Hospital for Sick Children, Department of Biochemistry, University of Toronto, Toronto, Canada., Pavie B; VIB-BioImaging Core, VIB-Center for Brain and Disease Research, Leuven, Belgium., Wierda K; Electrophysiology Expertise Unit, VIB-Center for Brain and Disease Research, Leuven, Belgium., Eskelinen EL; Institute of Biomedicine, University of Turku, Turku, Finland., Annaert W; Laboratory for Membrane Trafficking, VIB-Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, KU Leuven, Leuven, Belgium. Electronic address: wim.annaert@kuleuven.be.

Publikováno v: Developmental cell [Dev Cell] 2024 Jun 17; Vol. 59 (12), pp. 1571-1592.e9. Date of Electronic Publication: 2024 Apr 15.

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.

Autor: Fernandez-Mosquera L; a Institute of Cellular Biochemistry, University Medical Center Goettingen , Goettingen , Germany.; b Doctoral Program in Molecular Medicine, Georg August University Goettingen , Goettingen , Germany., Yambire KF; a Institute of Cellular Biochemistry, University Medical Center Goettingen , Goettingen , Germany.; c International Max-Planck Research School in Neuroscience , Goettingen , Germany.; d European Neuroscience Institute Goettingen, University Medical Center Goettingen and Max-Planck Society , Goettingen , Germany., Couto R; a Institute of Cellular Biochemistry, University Medical Center Goettingen , Goettingen , Germany.; e Doctoral Program in Molecular Biology of Cells, Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, University of Goettingen , Goettingen , Germany., Pereyra L; a Institute of Cellular Biochemistry, University Medical Center Goettingen , Goettingen , Germany.; e Doctoral Program in Molecular Biology of Cells, Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, University of Goettingen , Goettingen , Germany., Pabis K; a Institute of Cellular Biochemistry, University Medical Center Goettingen , Goettingen , Germany., Ponsford AH; f Institute of Translational Medicine, University of Liverpool , Liverpool , UK., Diogo CV; a Institute of Cellular Biochemistry, University Medical Center Goettingen , Goettingen , Germany., Stagi M; f Institute of Translational Medicine, University of Liverpool , Liverpool , UK., Milosevic I; d European Neuroscience Institute Goettingen, University Medical Center Goettingen and Max-Planck Society , Goettingen , Germany., Raimundo N; a Institute of Cellular Biochemistry, University Medical Center Goettingen , Goettingen , Germany.

Publikováno v: Autophagy [Autophagy] 2019 Sep; Vol. 15 (9), pp. 1572-1591. Date of Electronic Publication: 2019 Mar 27.