Follicle-intrinsic and spatially distinct molecular programs drive follicle rupture and luteinization during ex vivo mammalian ovulation.

Autor: Zaniker EJ; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Zhang J; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA., Russo D; Institute for Medical Engineering & Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Huang R; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA., Suritis K; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA., Drake RS; Institute for Medical Engineering & Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Barlow-Smith E; Micrographia Bio, London, UK., Shalek AK; Institute for Medical Engineering & Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA., Woodruff TK; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Department of Obstetrics and Gynecology, Michigan State University, East Lansing, MI, USA., Xiao S; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA., Goods BA; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA. britt.anne.goods@dartmouth.edu., Duncan FE; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. f-duncan@northwestern.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Oct 23; Vol. 7 (1), pp. 1374. Date of Electronic Publication: 2024 Oct 23.

Follicle-intrinsic and spatially distinct molecular programs drive follicle rupture and luteinization during ex vivo mammalian ovulation

Autor: Emily J. Zaniker, Jiyang Zhang, Daniela Russo, Ruixu Huang, Kristine Suritis, Riley S. Drake, Esther Barlow-Smith, Alex K. Shalek, Teresa K. Woodruff, Shuo Xiao, Brittany A. Goods, Francesca E. Duncan

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-23 (2024)

Abstract During ovulation, the apical wall of the preovulatory follicle breaks down to facilitate gamete release. In parallel, the residual follicle wall differentiates into a progesterone-producing corpus luteum. Disruption of ovulation, whether thr

Externí odkaz: https://doaj.org/article/422a5bda6fd7443eb783b07c2b18ee4b

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Lipid droplets synthesized during luteinization are degraded after pregnancy

Autor: Junichiro MITSUI, Megumi IBAYASHI, Ryutaro AIZAWA, Tomonori ISHIKAWA, Naoyuki MIYASAKA, Satoshi TSUKAMOTO

Publikováno v: The Journal of Reproduction and Development, Vol 70, Iss 2, Pp 72-81 (2024)

After pregnancy, the corpus luteum (CL) functions as a transient endocrine gland that produces progesterone, which is necessary to maintain pregnancy. To maintain constant progesterone production, CLs are enriched in lipids as its precursors. Lipid d

Externí odkaz: https://doaj.org/article/309af2c05c054971bf0a9bb487531679

Persistently expressed human chorionic gonadotropin induces premature luteinization and progressive alterations on the reproductive axis in female mice

Autor: Marcial Lopez, Agustina, Ratner, Laura D., Martinez, Carolina S., Di Giorgio, Noelia, Poutanen, Matti, Huhtaniemi, Ilpo T., Rulli, Susana B.

Publikováno v: In General and Comparative Endocrinology 15 May 2023 336