Anti-Fibrotic Effect of SDF-1β Overexpression in Bleomycin-Injured Rat Lung

Autor: Kleanthis Fytianos, Ronja Schliep, Sofia Mykoniati, Petra Khan, Katrin E. Hostettler, Michael Tamm, Amiq Gazdhar, Lars Knudsen, Thomas Geiser

Publikováno v: Pharmaceutics, Vol 14, Iss 9, p 1803 (2022)

Rational: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease and is associated with high mortality due to a lack of effective treatment. Excessive deposition of the extracellular matrix by activated myofibroblasts in the a

Externí odkaz: https://doaj.org/article/6ff6c85232764027abcf47fc9676c396

Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro

Autor: Anis Feki, Izabela Nita, Luca Tamò, Kleanthis Fytianos, Fabienne Caldana, Cedric Simillion, Thomas Geiser, Amiq Gazdhar, Manfred Heller

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 2
Tamò, Luca; Fytianos, Kleanthis; Caldana, Fabienne; Simillion, Cedric; Feki, Anis; Nita, Izabela; Heller, Manfred; Geiser, Thomas; Gazdhar, Amiq (2021). Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro. International journal of molecular sciences, 22(2) MDPI 10.3390/ijms22020958
International Journal of Molecular Sciences, Vol 22, Iss 958, p 958 (2021)

Simple Summary Macrophages play essential role in repair, regeneration and tissue remodeling. Role of macrophages in progression of lung fibrosis is established. Secretome of Induced pluripotent stem cells (iPSC-CM) has shown to reduce lung fibrosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0b59075bd531936bda4d6b94a778a4
http://europepmc.org/articles/PMC7835982

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