Zobrazeno 1 - 10
of 6 646
pro vyhledávání: '"lung fibrosis"'
Autor:
Aiyuan Zhou, Xiyan Zhang, Xinyue Hu, Tiao Li, Wenzhong Peng, Hang Yang, Dingding Deng, Chunheng Mo, Rongli Lu, Pinhua Pan
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Interferon regulatory factor-1 (IRF1) is a transcription factor that plays a significant role in various biological processes, including inflammatory injury, viral infection, cell death, and immune responses, and it has been exten
Externí odkaz:
https://doaj.org/article/2d08207743c6431082520b192b22ec89
Autor:
Davide Buseghin, Andrea Grandi, Erica Ferrini, Gino Villetti, Roberta Ciccimarra, Nicola Sverzellati, Andrea Aliverti, Francesca Pennati, Franco Fabio Stellari
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background Idiopathic Pulmonary Fibrosis (IPF), prevalently affecting individuals over 60 years of age, has been mainly studied in young mouse models. The limited efficacy of current treatments underscores the need for animal models that bet
Externí odkaz:
https://doaj.org/article/202c88ebbc6146dc8d65c64f107a171f
Autor:
Alzahrani AR, Mohamed DI, Abo Nahas HH, Alaa El-Din Aly El-Waseef D, Altamimi AS, Youssef IH, Ibrahim IAA, Mohamed SM, Sabry YG, Falemban AH, Elhawary NA, Bamagous GA, Jaremko M, Saied EM
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 3959-3986 (2024)
Abdullah R Alzahrani,1 Doaa I Mohamed,2 Hebatallah H Abo Nahas,3 Dalia Alaa El-Din Aly El-Waseef,4 Abdulmalik S Altamimi,5 Ibrahim H Youssef,6 Ibrahim Abdel Aziz Ibrahim,1 Soha MY Mohamed,7 Yasmine Gamal Sabry,7 Alaa H Falemban,1 Nasser Attia Elhawar
Externí odkaz:
https://doaj.org/article/a852fdc836c74598a206f004550082bc
Autor:
Martina Buccardi, Andrea Grandi, Erica Ferrini, Davide Buseghin, Gino Villetti, Maurizio Civelli, Nicola Sverzellati, Andrea Aliverti, Francesca Pennati, Franco Fabio Stellari
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a debilitating and fatal lung disease characterized by the excessive formation of scar tissue and decline of lung function. Despite extensive research, only two FDA-approved drugs exist for IPF, with li
Externí odkaz:
https://doaj.org/article/1d01f998850d481ab5eb44d736a8a6c0
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Interstitial lung disease (ILD) is the primary cause of mortality in systemic sclerosis (SSc), an autoimmune disease characterized by tissue fibrosis. SSc-related ILD (SSc-ILD) occurs more frequently in females aged 30–55 years,
Externí odkaz:
https://doaj.org/article/5f193c0c75cf4678a85082159fae9ecc
VISTA Deficiency Exacerbates the Development of Pulmonary Fibrosis by Promoting Th17 Differentiation
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 3983-3999 (2024)
Haiping Xie,1,* Xuexin Zhong,1,* Junlin Chen,2 Shuang Wang,1 Yuefang Huang,2 Niansheng Yang1 1Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of
Externí odkaz:
https://doaj.org/article/93454107526d44bd82b7b8662fae031f
Autor:
Roberto Tonelli, Raffaella Rizzoni, Salvatore Grasso, Andrea Cortegiani, Lorenzo Ball, Anna Valeria Samarelli, Riccardo Fantini, Giulia Bruzzi, Luca Tabbì, Stefania Cerri, Linda Manicardi, Dario Andrisani, Filippo Gozzi, Ivana Castaniere, Marry R. Smit, Frederique Paulus, Lieuwe D. J. Bos, Enrico Clini, Alessandro Marchioni
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Patients with acute exacerbation of lung fibrosis with usual interstitial pneumonia (EUIP) pattern are at increased risk for ventilator-induced lung injury (VILI) and mortality when exposed to mechanical ventilation (MV). Yet, lack of a mech
Externí odkaz:
https://doaj.org/article/68a17f8286dc461781c9d2ee2135dae7
Autor:
Chih-Wen Wang, Hsin-Ying Clair Chiou, Szu-Chia Chen, Da-Wei Wu, Hung-Hsun Lin, Huang-Chi Chen, Wei-Ting Liao, Ming-Hong Lin, Chih-Hsing Hung, Chao-Hung Kuo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/3e10faa1cbfa49f5a7e62d7b4e362319
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
For many industrial chemicals toxicological data is sparse regarding several regulatory endpoints, so there is a high and often unmet demand for NAMs that allow for screening and prioritization of these chemicals. In this proof of concept case study
Externí odkaz:
https://doaj.org/article/7824a62fc0ef41bfba6176412284a191
Autor:
B.C. Agema, M. Berrich, L. Seuren, S.D.T. Sassen, J.R. Miedema, B.C.P. Koch, M.S. Wijsenbeek, S.L.W. Koolen, R.H.J. Mathijssen, G.D.M. Veerman
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117341- (2024)
Background: Nintedanib is used to treat both idiopathic and progressive pulmonary fibrosis (IPF/PPF). Evidence of both an exposure-response relationship and an exposure-toxicity relationship has been found, suggesting the potential value of therapeut
Externí odkaz:
https://doaj.org/article/ea5bbc70818248ff8532493c948a116b